Abstract:
:The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-gamma (IFN-gamma) stimulation. The regulation of IDO expression appears to differ in the two cell lines. Nitric oxide (NO) production negatively modulates the expression of IDO activity in IFN-gamma-primed macrophages, thereby indicating a cross-talk between the kynurenine and nitridergic pathways in these cells. Conversely, this down-regulation of IDO activity by NO does not occour in microglial cells. A differential regulation of IDO expression in the two cell lines was also observed with LPS and picolinic acid. Together with previous findings, these results indicate the existence of marked differences in the regulation of the expression of the kynurenine pathway enzymes between macrophages and microglial cells.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Alberati-Giani D,Cesura AMdoi
10.1007/BF01345271subject
Has Abstractpub_date
1998-01-01 00:00:00pages
251-5issue
1-3eissn
0939-4451issn
1438-2199journal_volume
14pub_type
杂志文章相关文献
AMINO ACIDS文献大全abstract::Effects of taurine on the delayed rectifier K(+) channel in isolated 10-day-old embryonic chick ventricular cardiomyocytes were examined at different intracellular Ca(2+) concentrations ([Ca]i), using whole-cell voltage and current clamp techniques. Experiments were performed at room temperature (22°C). Test pulses we...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805955
更新日期:1995-09-01 00:00:00
abstract::The present research has been carried out to elicit the mechanism of antiangiogenic activity of a fusion peptide P2. Peptide P2 was designed by the connection of a heptapeptide MMP inhibitor to ES-2, a fragment of Endostatin. In a previous study, P2 demonstrated strong antiangiogenic and antitumor effect, and the curr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2589-4
更新日期:2018-08-01 00:00:00
abstract::This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protoco...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0837-y
更新日期:2012-04-01 00:00:00
abstract::Thrombin, the most potent physiological platelet agonist interacts with cells through a specific G protein-coupled receptor which has been cloned and sequenced. Synthetic thrombin receptor peptides (TRAPs) comprising the first 5 amino acids (SFLLR and SFLLR-NH2) of the new N-terminus tethered ligand of the thrombin re...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF01318860
更新日期:1998-01-01 00:00:00
abstract::Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF01345283
更新日期:1998-01-01 00:00:00
abstract::Hypotaurine, concentrated under reduced pressure in HCl solution, partially (30-40%) degrades into taurine (about 30%), 2-aminoethyl-2-aminoethanethiolsulfonate (about 10%) and ethanolamine. The degradation products were identified using LC/APCI-MS, NMR, amino acid analysis and various chromatographies. The identities...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF01320900
更新日期:1998-01-01 00:00:00
abstract::This study aimed to evaluate the effect of taurine (tau) supplementation to low fishmeal (FM) diets on growth performance, oxidative status, and immune response of European seabass juveniles. Four isoproteic (46% crude protein) and isolipidic (19% crude lipid) diets were formulated to contain either 25 or 12.5% FM and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02769-4
更新日期:2019-09-01 00:00:00
abstract::Extracellular peptide ligand binding sites, which bind the N-termini of angiotensin II (AngII) and bradykinin (BK) peptides, are located on the N-terminal and extracellular loop 3 regions of the AT(1)R and BKRB(1) or BKRB(2) G-protein-coupled receptors (GPCRs). Here we synthesized peptides P15 and P13 corresponding to...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1405-9
更新日期:2013-03-01 00:00:00
abstract::Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (RSA) of amino acids within a protein is a significant step towards re...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02767-6
更新日期:2019-09-01 00:00:00
abstract::Interplay between proteins, nucleic acids, carbohydrates and/or lipids is involved in almost every process in life on earth. As a consequence, a wide range of diseases results from abnormal interactions of such biomolecules. The main motivation of foldamer science is the development of scaffolds that are capable of ad...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0894-2
更新日期:2011-08-01 00:00:00
abstract::The presence of an enzyme activity which hydrolyzes glycyl-D-aspartate was found in the homogenates of pig kidney cortex. The activity was inhibited by metal chelating agents and cilastatin, suggesting that the enzyme was a cilastatin-sensitive metallo-peptidase. Of the two hydrolysis products,D-aspartate was found to...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00806591
更新日期:1996-06-01 00:00:00
abstract::The epidermal growth factor receptor (EGFR) represents an important molecular target for both radiotracer-based diagnostic imaging and radionuclide therapy of various cancer entities. For the delivery of radionuclides to the tumor, peptides hold great potential as a transport vehicle. With respect to EGFR, the peptide...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2616-5
更新日期:2018-10-01 00:00:00
abstract::A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2375-0
更新日期:2017-04-01 00:00:00
abstract::The nucleotide (ATP-ADP)/nucleoside (adenosine) ratio in the circulation can modulate the processes of vasoconstriction, vasodilatation and platelet aggregation. The main objective of the present study with rat blood serum was to evaluate the possibility of changes in nucleotide hydrolysis by phenylalanine (Phe) and p...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-002-0345-1
更新日期:2003-06-01 00:00:00
abstract::Based on previous research with bovine peadipocytes, we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c.) adipose tissue, and that this would be attenuated by conjugated linoleic acid (CLA). Growing Angus stee...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1622-x
更新日期:2014-02-01 00:00:00
abstract::Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0721-1
更新日期:2011-03-01 00:00:00
abstract::L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02783-6
更新日期:2019-11-01 00:00:00
abstract::Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0791-0
更新日期:2011-10-01 00:00:00
abstract::The purpose of the present study was to investigate the relationship between plasma carnitine concentration and body composition variation in relation to muscular and fat masses since there is no experimentally proved correlation between plasma carnitine and body masses. We used bioelectric impedance analysis (BIA), t...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF01318855
更新日期:1998-01-01 00:00:00
abstract::Spermine oxidase (SMO) was discovered much more recently than other enzymes involved in polyamine metabolism; this review summarizes 10 years of researches on this enzyme. Spermine oxidase (SMO) is a FAD-dependent enzyme that specifically oxidizes spermine (Spm) and plays a dominant role in the highly regulated mammal...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1014-z
更新日期:2012-02-01 00:00:00
abstract::Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by the defects in the phenylalanine hydroxylase (PAH) gene. Individuals homozygous for defective PAH alleles show elevated levels of systemic phenylalanine and should be under strict dietary control to reduce the risk of neuronal damage associated ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-005-0218-5
更新日期:2005-11-01 00:00:00
abstract::The polyamines spermidine and spermine, and their precursor putrescine, have been shown to play an important role in cell migration, proliferation, and differentiation. Because of their polycationic property, polyamines are traditionally thought to be involved in DNA replication, gene expression, and protein translati...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1879-8
更新日期:2015-03-01 00:00:00
abstract::Recently, crystalized mouse ketimine reductase/CRYM complexed with NADPH was found to have pyruvate bound in its active site. We demonstrate that the enzyme binds α-keto acids, such as pyruvate, in solution, and catalyzes the formation of N-alkyl-amino acids from alkylamines and α-keto acids (via reduction of imine in...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2044-8
更新日期:2015-11-01 00:00:00
abstract::The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for glutamate at a ratio of 1:1. It is composed of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge. Intracellularly, cystine is reduced into cysteine, the rate-limiting precursor of glutathione (...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0862-x
更新日期:2012-01-01 00:00:00
abstract::The study was designed to investigate the effects of NMDA receptor agonist on the behavioral activity in rats with experimental hyperammonemia. The experiments were performed on adult male Wistar rats. Experimental hyperammonemia was induced by intraperitoneal injections of tioacetamide (TAA, 200 mg/kg) for three cons...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-004-0122-4
更新日期:2005-02-01 00:00:00
abstract::Taking a minimalistic approach in efforts to lower the cost for the development of new synthetic antimicrobial peptides, ultrashort cationic lipopeptides were designed to mimic the amphiphilic nature crucial for their activity but with only a very short peptide sequence ligated to a lipidic acid. Nine ultrashort catio...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1806-z
更新日期:2014-11-01 00:00:00
abstract::Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/BF01388176
更新日期:1999-01-01 00:00:00
abstract::S-adenosylmethionine (SAM), a major substrate in 1-C metabolism is a common precursor in the biosynthetic pathways of polyamines and ethylene, two important plant growth regulators, which exhibit opposing developmental effects, especially during fruit ripening. However, the flux of various substrates including SAM int...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1624-8
更新日期:2014-03-01 00:00:00
abstract::Glucosinolates are amino acid-derived natural plant products found throughout the Capparales order. Glucosinolates and their degradation products have a wide range of biological activities, e.g. in plant defense as deterrents against insect and fungi. The conversion of amino acids to aldoximes is a key step in glucosi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s007260200014
更新日期:2002-01-01 00:00:00
abstract::Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2524-0
更新日期:2018-04-01 00:00:00