Abstract:
:The nucleotide (ATP-ADP)/nucleoside (adenosine) ratio in the circulation can modulate the processes of vasoconstriction, vasodilatation and platelet aggregation. The main objective of the present study with rat blood serum was to evaluate the possibility of changes in nucleotide hydrolysis by phenylalanine (Phe) and phenylpyruvate (PP), the levels of which could increase in the circulation of individuals with phenylketonuria. Results demonstrated that Phe in the range 1.0-5.0 mM inhibited the ADP hydrolysis by rat serum. The effect of inhibition by Phe on ATP hydrolysis appeared only at a concentration of 5.0 mM. PP had no significant effect upon nucleotide hydrolysis. Kinetic analysis indicated that the inhibition of ADP and ATP hydrolysis by Phe in rat blood serum is uncompetitive. Conversely, Phe and PP did not affect the hydrolysis of p-nitrophenyl-5'-TMP by rat serum.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Rücker B,Oses JP,Kirst IB,Berti SL,Bonan CD,Battastini AM,Sarkis JJdoi
10.1007/s00726-002-0345-1subject
Has Abstractpub_date
2003-06-01 00:00:00pages
383-8issue
4eissn
0939-4451issn
1438-2199journal_volume
24pub_type
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