Age-related salivary polyamine increase in adolescents wearing orthodontic Ni-Ti archwires.

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put ...

journal_title：Amino acids

authors： Perna AF,Ingrosso D,De Santo NG

更新日期：2003-12-01 00:00:00

abstract：:Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnos...

journal_title：Amino acids

authors： Baye E,Ukropcova B,Ukropec J,Hipkiss A,Aldini G,de Courten B

更新日期：2016-05-01 00:00:00

abstract：:Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...

journal_title：Amino acids

authors： Kuhn-Nentwig L,Willems J,Seebeck T,Shalaby T,Kaiser M,Nentwig W

更新日期：2011-01-01 00:00:00

abstract：:Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...

journal_title：Amino acids

authors： Mera A,de Lima MZT,Bernardes A,Garcia W,Muniz JRC

更新日期：2019-04-01 00:00:00

abstract：:Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine tota...

journal_title：Amino acids

authors： Hill CA,Harris RC,Kim HJ,Harris BD,Sale C,Boobis LH,Kim CK,Wise JA

更新日期：2007-02-01 00:00:00

abstract：:The objective of the study was to test L-methioinine as a possible immune supportive supplement in HIV infected patients by means of a clinical study. A double-blind, placebo-controlled study was designed. The patients (n = 253) from four different trial centres were randomly divided into two groups, active and placeb...

journal_title：Amino acids

authors： Van Brummelen R,du Toit D

更新日期：2007-07-01 00:00:00

abstract：:eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...

journal_title：Amino acids

authors： Dias CA,Gregio AP,Rossi D,Galvão FC,Watanabe TF,Park MH,Valentini SR,Zanelli CF

更新日期：2012-02-01 00:00:00

abstract：:Immobilization of papain on Sepharose 6B in the presence of different concentrations of cysteine affected the enzyme activity depending on cysteine concentration. The maximum specific activity was observed when papain was immobilized with 200 mM cysteine. The immobilization process brought significant enhancement of s...

journal_title：Amino acids

authors： Homaei AA,Sajedi RH,Sariri R,Seyfzadeh S,Stevanato R

更新日期：2010-03-01 00:00:00

abstract：:This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status, proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like receptor-4 (TLR4), and aquaporin-8 in a lipopolysaccharide (LPS)-challenged piglet model. Eighteen piglets (35-day-old) were randomly alloc...

journal_title：Amino acids

authors： Hou Y,Wang L,Yi D,Ding B,Yang Z,Li J,Chen X,Qiu Y,Wu G

更新日期：2013-09-01 00:00:00

abstract：:A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/tert-butyl (Fmoc/tBu) methodology and with the standard N,N'-...

journal_title：Amino acids

authors： Friligou I,Papadimitriou E,Gatos D,Matsoukas J,Tselios T

更新日期：2011-05-01 00:00:00

abstract：:Delta-amino acids are very attractive in drug discovery, especially in the peptidomimetic area, because of their capability to act as dipeptide isosteres and reverse turn mimetics. Herein we report the synthesis of a rigid delta-amino acid constrained by a 3-aza-6,8-dioxabicyclo[3.2.1]octane-based scaffold, which can ...

journal_title：Amino acids

authors： Trabocchi A,Menchi G,Danieli E,Guarna A

更新日期：2008-06-01 00:00:00

abstract：:We present an optimized procedure for the synthesis of (S)-vinylglycine from (S)-methionine. The key step is a solvent free pyrolysis of an intermediate sulfoxide at high temperature. Using our optimized reaction conditions, Cbz-protected vinylglycine was obtained in high yield and with almost no side products. The pr...

journal_title：Amino acids

authors： Küchenthal CH,Migenda J,Polednia M,Maison W

更新日期：2010-07-01 00:00:00

abstract：:The lens transparency depends on higher concentration of lens proteins and their interactions. α-Crystallin is one of the predominant lens proteins, responsible for proper structural and functional architecture of the lens microenvironment, and any alteration of which results in cataract formation. The R12C, R21L, R49...

journal_title：Amino acids

authors： Ramkumar S,Fujii N,Sakaue H,Fujii N,Thankappan B,kumari RP,Natarajaseenivasan K,Anbarasu K

更新日期：2015-05-01 00:00:00

abstract：:Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated...

journal_title：Amino acids

authors： Schmid HA

更新日期：1998-01-01 00:00:00

abstract：:This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise...

journal_title：Amino acids

authors： Maroto-Sánchez B,Lopez-Torres O,Valtueña J,Benito PJ,Palacios G,Díaz-Martínez ÁE,González-Lamuño D,Zinellu A,González-Gross M,Carru C

更新日期：2019-02-01 00:00:00

abstract：:Glutamate is stored in synaptic vesicles in presynaptic neurons. It is released into the synaptic cleft to provide signalling to postsynaptic neurons. Normally, the astroglial glutamate transporters GLT-1 and GLAST take up glutamate to mediate a high signal-to-noise ratio in the synaptic signalling, and also to preven...

journal_title：Amino acids

authors： Persson M,Rönnbäck L

更新日期：2012-01-01 00:00:00

abstract：:Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...

journal_title：Amino acids

authors： Patsialas K,Koutsas C,Makris P,Liakopoulou-Kyriakides M

更新日期：2010-07-01 00:00:00

abstract：:The kidney plays a key role in arginine metabolism. Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which ...

journal_title：Amino acids

authors： Levillain O

更新日期：2012-04-01 00:00:00

abstract：:The tailor made amino acid β-N-methyl-amino-L-alanine (BMAA) is a neurotoxin produced by cyanobacteria. It has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Some different reports of BMAA in cyanobacterial blooms f...

journal_title：Amino acids

authors： Cervantes Cianca RC,Baptista MS,Lopes VR,Vasconcelos VM

更新日期：2012-06-01 00:00:00

abstract：:Reduced glutathione (GSH) levels and glutathione reductase (GR) and glutathione S-transferase (GST) activities were investigated in the erythrocytes and lymphocytes of non-dialyzed patients with varying degrees of chronic renal insufficiency, and also of patients on regular hemodialysis treatment. GSH, GR and GST leve...

journal_title：Amino acids

authors： Mimic-Oka J,Simic T,Djukanovic L,Stefanovski J,Ramic Z

更新日期：1992-10-01 00:00:00

abstract：:O-linked β-N-actylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in a variety of cellular processes. O-GlcNAc was termed a nut...

journal_title：Amino acids

authors： Ma Z,Vosseller K

更新日期：2013-10-01 00:00:00

abstract：:We describe six children with tetrahydrobiopterin (BH(4)) responsive phenylalanine hydroxylase (PAH) deficiency. All patients carry two mutant alleles in the PAH gene. Cofactor deficiency was excluded. The effect of BH(4) administration was studied by correlating different oral BH(4) doses with plasma phenylalanine le...

journal_title：Amino acids

authors： Steinfeld R,Kohlschütter A,Ullrich K,Lukacs Z

更新日期：2003-07-01 00:00:00

abstract：:When a V3 sequence obtained on the n-th year after infection with human immunodeficiency virus type 1 (HIV-1) was supposed to change into a V3 sequence on the n + 1-th year, the variation between the above two sequences was analyzed by means of entropic chaos degree. The entropic chaos degree measures chaotic aspects ...

journal_title：Amino acids

authors： Sato K,Ohya M

更新日期：2001-01-01 00:00:00

abstract：:Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...

journal_title：Amino acids

authors： Golubnitschaja O,Filep N,Yeghiazaryan K,Blom HJ,Hofmann-Apitius M,Kuhn W

更新日期：2018-04-01 00:00:00

abstract：:The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activit...

journal_title：Amino acids

authors： Khalily MP,Gerekçi S,Güleç EA,Özen C,Özçubukçu S

更新日期：2018-11-01 00:00:00

abstract：:Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...

journal_title：Amino acids

authors： Militante JD,Lombardini JB

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to investigate H(e) concentration in plasma from 80 healthy donors in relation to age (6 newborns are also included), sex, daily variation (9, 11 a.m.; 2, 6, 12 p.m.) and a period of 5 subsequent months. A significant correlation (r = 0.63, p < 0.001) was observed between plasma H(e) and ...

journal_title：Amino acids

authors： Fermo I,De Vecchi E,D'Angelo SV,D'Angelo A,Paroni R

更新日期：1993-02-01 00:00:00

abstract：:Filamentous fungi of the genusHypocrea were grown on malt extract/peptone agar, the mycelia were extracted with dichloromethane/methanol, and the extracts were totally hydrolyzed with 6 N HCl (110°C, 24 h). The amino acids (AA) released from peptides were converted into theirN(O)-pen-tafluoropropionyl 1-propyl esters ...

journal_title：Amino acids

authors： Brückner H,Maisch J,Reinecke C,Kimonyo A

更新日期：1991-06-01 00:00:00

abstract：:In the article (Romek et al. 2013) we reported the values of δ15N (‰) and δ13C (‰) obtained by. ...

journal_title：Amino acids

authors： Romek KM,Julien M,Frasquet-Darrieux M,Tea I,Antheaume I,Hankard R,Robins RJ

更新日期：2018-01-01 00:00:00

abstract：:Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransfera...

journal_title：Amino acids

authors： Li H,Meininger CJ,Bazer FW,Wu G

更新日期：2016-10-01 00:00:00