Neurofilament proteins NF-L, NF-M and NF-H in brain of patients with Down syndrome and Alzheimer's disease.

abstract：:Polyamines are small organic polycations essential for cell proliferation and survival. Antizymes (AZs) are small proteins regulated by polyamines that inhibit polyamine biosynthesis and uptake in mammalian cells. In addition, antizyme functions are also regulated by antizyme inhibitors, homologue proteins of ornithin...

journal_title：Amino acids

authors： López-Contreras AJ,Ramos-Molina B,Cremades A,Peñafiel R

更新日期：2010-02-01 00:00:00

abstract：:Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α2-adrenergic and imidazoline receptors in the mammalian brain suggests that thi...

journal_title：Amino acids

authors： Akasaka N,Fujiwara S

更新日期：2020-02-01 00:00:00

abstract：:Transglutaminases (TGs) are a large family of related and ubiquitous enzymes that catalyze the cross-linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate. Considerable and intense progress has been made in the understanding of the chemistry, molecular biol...

journal_title：Amino acids

authors： Tabolacci C,Lentini A,Provenzano B,Beninati S

更新日期：2012-02-01 00:00:00

abstract：:We performed sensory evaluations on 141 bottles of sake and analyzed the relationship between the D-amino acid concentrations, and the taste of the sake using principal component analysis, which yielded seven principal components (PC1-7) that explained 100 % of the total variance in the data. PC1, which explains 33.6 ...

journal_title：Amino acids

authors： Okada K,Gogami Y,Oikawa T

更新日期：2013-02-01 00:00:00

abstract：:There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application...

journal_title：Amino acids

authors： Gualano B,Roschel H,Lancha AH Jr,Brightbill CE,Rawson ES

更新日期：2012-08-01 00:00:00

abstract：:Based on previous research with bovine peadipocytes, we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c.) adipose tissue, and that this would be attenuated by conjugated linoleic acid (CLA). Growing Angus stee...

journal_title：Amino acids

authors： Choi SH,Wickersham TA,Wu G,Gilmore LA,Edwards HD,Park SK,Kim KH,Smith SB

更新日期：2014-02-01 00:00:00

abstract：:Tryptophanase is and is perfectly inert to D-tryptophan under ordinary conditions. However, activity that can degrade D-tryptophan into indole is observed when tryptophanase is in highly concentrated diammoniumhydrogen phosphate solution. The reaction has been so far unknown in tryptophanase metabolic pathways. Here w...

journal_title：Amino acids

authors： Shimada A,Shishido H,Nakamura I

更新日期：1996-03-01 00:00:00

abstract：:Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

journal_title：Amino acids

authors： Jong CJ,Ito T,Schaffer SW

更新日期：2015-12-01 00:00:00

abstract：:Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...

journal_title：Amino acids

authors： Kanda-Nambu K,Yasuda Y,Tochikubo K

更新日期：2000-01-01 00:00:00

abstract：:Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...

journal_title：Amino acids

authors： Terui Y,Saroj SD,Sakamoto A,Yoshida T,Higashi K,Kurihara S,Suzuki H,Toida T,Kashiwagi K,Igarashi K

更新日期：2014-03-01 00:00:00

abstract：:The objective of the study was to test L-methioinine as a possible immune supportive supplement in HIV infected patients by means of a clinical study. A double-blind, placebo-controlled study was designed. The patients (n = 253) from four different trial centres were randomly divided into two groups, active and placeb...

journal_title：Amino acids

authors： Van Brummelen R,du Toit D

更新日期：2007-07-01 00:00:00

abstract：:Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium ph...

journal_title：Amino acids

authors： Atanassova SS,Panchev P,Ivanova M

更新日期：2010-05-01 00:00:00

abstract：:Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...

journal_title：Amino acids

authors： Mera A,de Lima MZT,Bernardes A,Garcia W,Muniz JRC

更新日期：2019-04-01 00:00:00

abstract：:L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...

journal_title：Amino acids

authors： Hanff E,Said MY,Kayacelebi AA,Post A,Minovic I,van den Berg E,de Borst MH,van Goor H,Bakker SJL,Tsikas D

更新日期：2019-11-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) plays a vital role in the progress of malignant disease and elevated Hsp90 expression has been reported in pancreatic cancer. In this study, we radiolabeled a dimeric Sansalvamide A derivative (Di-San A1) with 64Cu, and evaluated the feasibility of using 64Cu-Di-San A1 for PET imaging of ...

journal_title：Amino acids

authors： Wang X,Zhang J,Wu H,Li Y,Conti PS,Chen K

更新日期：2018-07-01 00:00:00

abstract：:This paper analyses the presence of and changes in free amino acids and biogenic amines in red and white muscle of bigeye tuna during storage in controlled atmospheres with 2 gas mixes containing different concentrations of CO(2) and O(2). Levels of amines were generally higher in white than in red muscle, with the ex...

journal_title：Amino acids

authors： Ruiz-Capillas C,Moral A

更新日期：2004-03-01 00:00:00

abstract：:A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction o...

journal_title：Amino acids

authors： Kil JS,Jeong SO,Chung HT,Pae HO

更新日期：2017-04-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (TAT) protein, a member of the protein transduction domain (PTD) superfamily, can deliver heterologous proteins across most biomembranes without losing bioactivity. However, there is no report on whether the TAT core domain containing the ...

journal_title：Amino acids

authors： Wu Y,Ren C,Gao Y,Hou B,Chen T,Zhang C

更新日期：2010-08-01 00:00:00

abstract：:The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO), which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used to study the effect of BCAAs on mammalian target of rapamycin complex 1 (mTORC1) regulation of organ size. BCATm is the first enzyme in the BCAA cat...

journal_title：Amino acids

authors： Neishabouri SH,Hutson SM,Davoodi J

更新日期：2015-06-01 00:00:00

abstract：:Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransfera...

journal_title：Amino acids

authors： Li H,Meininger CJ,Bazer FW,Wu G

更新日期：2016-10-01 00:00:00

abstract：:We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were s...

journal_title：Amino acids

authors： Ahn CW,Kwon DY,Jun DS,Lee YM,Kim YC

更新日期：2015-06-01 00:00:00

abstract：:Extracellular peptide ligand binding sites, which bind the N-termini of angiotensin II (AngII) and bradykinin (BK) peptides, are located on the N-terminal and extracellular loop 3 regions of the AT(1)R and BKRB(1) or BKRB(2) G-protein-coupled receptors (GPCRs). Here we synthesized peptides P15 and P13 corresponding to...

journal_title：Amino acids

authors： Lopes DD,Vieira RF,Malavolta L,Poletti EF,Shimuta SI,Paiva AC,Schreier S,Oliveira L,Nakaie CR

更新日期：2013-03-01 00:00:00

abstract：:Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the me...

journal_title：Amino acids

authors： Suenaga R,Yamane H,Tomonaga S,Asechi M,Adachi N,Tsuneyoshi Y,Kurauchi I,Sato H,Denbow DM,Furuse M

更新日期：2008-06-01 00:00:00

abstract：:Our observations on the growth stimulatory nature of mimosine, (beta-(3-hydroxy-4-pyridon-1-yl)-L-alanine), the toxic non-protein plant amino acid, in some model experimental systems, warranted sensitive and selective routine estimations. For the determination of both mimosine and DHP, an indirect spectrophotometric m...

journal_title：Amino acids

authors： Lalitha K,Rajendra Kulothungan S

更新日期：2006-10-01 00:00:00

abstract：:Reports on nucleobase-containing chiral peptides (both natural and artificial) and achiral pseudopeptides are reviewed. Their synthesis, structural features, DNA and RNA-binding ability, as well as some other interesting applications which make them promising diagnostic/therapeutic agents of great importance in many a...

journal_title：Amino acids

authors： Roviello GN,Benedetti E,Pedone C,Bucci EM

更新日期：2010-06-01 00:00:00

abstract：:Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

journal_title：Amino acids

authors： Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

更新日期：2010-11-01 00:00:00

abstract：:In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...

journal_title：Amino acids

authors： Kang YH,Lee KA,Kim JH,Park SG,Yoon DY

更新日期：2010-11-01 00:00:00

abstract：:Oxidative stress, an excess of reactive oxygen species (ROS), may lead to oxidative post-translational modifications of proteins resulting in the cleavage of the peptide backbone, known as α-amidation, and formation of fragments such as peptide amides and α-ketoacyl peptides (α-KaP). In this study, we first compared d...

journal_title：Amino acids

authors： Sajapin J,Hellwig M

更新日期：2020-10-01 00:00:00

abstract：:Taking a minimalistic approach in efforts to lower the cost for the development of new synthetic antimicrobial peptides, ultrashort cationic lipopeptides were designed to mimic the amphiphilic nature crucial for their activity but with only a very short peptide sequence ligated to a lipidic acid. Nine ultrashort catio...

journal_title：Amino acids

authors： Domalaon R,Yang X,O'Neil J,Zhanel GG,Mookherjee N,Schweizer F

更新日期：2014-11-01 00:00:00

abstract：:Due to the obvious advantages of long-acting peptide and protein drugs, strategies to prolong plasma half life time of such compounds are highly on demand. Short plasma half life times are commonly due to fast renal clearance as well as to enzymatic degradation occurring during systemic circulation. Modifications of t...

journal_title：Amino acids

authors： Werle M,Bernkop-Schnürch A

更新日期：2006-06-01 00:00:00