解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Stimulated Raman scattering (SRS) microscopy is a label-free method generating images based on chemical contrast within samples, and has already shown its great potential for high-sensitivity and fast imaging of biological specimens. The capability of SRS to collect molecular vibrational signatures in bio-samples, cou...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900028
更新日期:2019-09-01 00:00:00
abstract::Noninvasive body shaping is becoming a growing demand. The aim of this study was to investigate the efficacy and safety of the combined treatments of 1064 nm Nd:YAG and 2940 nm Er:YAG in noninvasive lipolysis and skin tightening. Ten females were enrolled, and all women's side of the waist or the lower part of the abd...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900083
更新日期:2019-09-01 00:00:00
abstract::We combined Michelson-interferometer-based off-axis digital holographic microscopy (DHM) with a common flow cytometry (FCM) arrangement. Utilizing object recognition procedures and holographic autofocusing during the numerical reconstruction of the acquired off-axis holograms, sharply focused quantitative phase images...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900085
更新日期:2019-09-01 00:00:00
abstract::Currently, the targeted treatment of tumor based on the tumor microenvironment is newly developed. Blood vessels are the key parts in the tumor microenvironment, which is taken as a new visible target for tumor therapy. Multiphoton microscopy (MPM), based on the second harmonic generation and two-photon excited fluore...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900006
更新日期:2019-09-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a wide range of survival times. We aimed to explore prognostic factors related to short survival based on clinical features and plasma metabolic signatures using surface-enhanced Raman spectroscopy (SERS). One hundred and thirty-eight sporad...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900012
更新日期:2019-08-01 00:00:00
abstract::We present a noninvasive and noncontacting biosensor using Wavelength Modulated Differential Photothermal Radiometry (WM-DPTR) to monitor blood glucose concentration (BGC) through interstitial fluid (ISF) probing in human middle fingers. WM-DPTR works in the interference-free mid-infrared range with differential wavel...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800441
更新日期:2019-07-01 00:00:00
abstract::The aim of the present study is to optimize parameters for inhibiting neuronal activity safely and investigating thermal inhibition of rat cortex neural networks in vitro by continuous infrared (IR) laser. Rat cortex neurons were cultured on multi-electrode arrays until neural networks were formed with spontaneous neu...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800403
更新日期:2019-07-01 00:00:00
abstract::Alveolar type II (ATII) cells in the peripheral human lung spontaneously differentiate toward ATI cells, thus enabling air-blood barrier formation. Here, linear Raman and coherent anti-Stokes Raman scattering (CARS) microscopy are applied to study cell differentiation of freshly isolated ATII cells. The Raman spectra ...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201800052
更新日期:2019-06-01 00:00:00
abstract::Delay-and-sum (DAS) is one of the most common algorithms used to construct the photoacoustic images due to its low complexity. However, it results in images with high sidelobes and low resolution. Delay-and-standard-deviation (DASD) weighting factor can improve the contrast of the images compared to DAS. However, it s...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800292
更新日期:2019-06-01 00:00:00
abstract::Achieving a maximal safe extent of resection during brain tumor surgery is the goal for improved patient prognosis. Fluorescence-guided neurosurgery using 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX has thereby become a valuable tool enabling a high frequency of complete resections and a prolonged progress...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800378
更新日期:2019-06-01 00:00:00
abstract::Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to characteristic increases in dermal fibroblast proliferation and collagen deposition through upregulation in components of the transforming growth factor beta (TGF-B)/SMAD pathway. In contrast to ultraviolet phototherapy, high-fluence...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800207
更新日期:2019-05-01 00:00:00
abstract::There has been increasing use of in vitro cell culture models that more realistically replicate the three-dimensional (3D) environment found in vivo. Multicellular tumor spheroids (MTS) using cell lines or patient-derived organoids have become an important in vitro drug development tool, where cells are grown in a 3D ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800201
更新日期:2019-05-01 00:00:00
abstract::Therapeutically exploiting vascular and metabolic endpoints becomes critical to translational cancer studies because altered vascularity and deregulated metabolism are two important cancer hallmarks. The metabolic and vascular phenotypes of three sibling breast tumor lines with different metastatic potential are inves...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800372
更新日期:2019-04-01 00:00:00
abstract::A robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Am...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800333
更新日期:2019-04-01 00:00:00
abstract::Clinicians need a way to rapidly and reliably test the correct functioning of near-infrared spectroscopy (NIRS)-based oximeters. Therefore, optical phantoms for quality assessment of NIRS oximeters are needed. The fabrication of such phantoms that mimic the optical properties of biological tissue in the NIR range repr...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800300
更新日期:2019-04-01 00:00:00
abstract::Modified nucleoside in urine samples is one of the most common biomarkers for cancer screening. Therefore, we developed a novel detection method for modified nucleoside detection in human urine. In this work, the modified nucleoside from real cancer patient's urine samples was first separated and purified using the af...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800327
更新日期:2019-04-01 00:00:00
abstract::To this day, any photosensitizers for the photodynamic treatment of pulmonary illnesses have been administered intravenously. There is, however, an intrinsic difficulty in reaching the target cells or bacteria in the respiratory system. Nebulization could overcome distribution problems and alleviate side effects by de...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800189
更新日期:2019-04-01 00:00:00
abstract::Osteocytes are the most abundant cells in bone and always the focus of bone research. They are embedded in the highly scattering mineralized bone matrix. Consequently, visualizing osteocytes deep in bone with subcellular resolution poses a major challenge for in vivo bone research. Here we overcome this challenge by d...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800360
更新日期:2019-04-01 00:00:00
abstract::Laser tweezers Raman spectroscopy (LTRS) as a label-free and noninvasive technology has been proven to be an ideal tool for analysis of single living cells, which provides important fingerprint information without interference from surrounding environments. For the first time, LTRS system was successfully used to exam...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800332
更新日期:2019-03-01 00:00:00
abstract::Photoacoustic microscopy (PAM) is a noninvasive imaging technique and is excellent to study structural and functional changes in the microcirculation. In this work, a lipopolysaccharide (LPS)-induced inflammation model in mice is noninvasively evaluated by PAM. PAM is used to image the microvascular structural changes...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800251
更新日期:2019-03-01 00:00:00
abstract::Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of diffe...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800080
更新日期:2019-03-01 00:00:00
abstract::We have developed a reflection-mode switchable subwavelength Bessel-beam (BB) and Gaussian-beam (GB) photoacoustic microscopy (PAM) system. To achieve both reflection-mode and high resolution, we tightly attached a very small ultrasound transducer to an optical objective lens with numerical aperture of 1.0 and working...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800215
更新日期:2019-02-01 00:00:00
abstract::One of the challenges in transcranial low-level laser therapy (LLLT) is to optimally choose illumination parameters, such as wavelength. However, there is sparse study on the wavelengths comparison especially on human transcranial LLLT. Here, we employed Monte Carlo modeling and visible human phantom to compute the pe...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800173
更新日期:2019-02-01 00:00:00
abstract::The purpose of this study was to evaluate the tomographic features of postrefractive surgery eyes. This was a retrospective evaluation of clinical data. Three patients with post-LASIK (laser-assisted in situ keratomileusis) and two patients with post-SMILE (small incision lenticule extraction) ectasia were imaged with...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800253
更新日期:2019-02-01 00:00:00
abstract::Atherosclerosis (AS), the leading cause of morbidity and mortality in cardiovascular disease, needs an early detection for treatment and prevention of fatal events. Here, for the first time, we applied gold nanorods (GNRs)-assisted diffusion reflection (DR), a noninvasive technique for in vivo detection of AS in a hig...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800218
更新日期:2019-01-01 00:00:00
abstract::Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection associated with impaired cerebral blood flow. Visualization of the eye vasculature, which is embryologically derived from that of the brain, is used clinically to diagnose the syndrome. Here, we introduce camera-phone laser speckle imagi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800098
更新日期:2019-01-01 00:00:00
abstract::Atherosclerosis is a process of thickening and stiffening of the arterial walls through the accumulation of lipids and fibrotic material, as a consequence of aging and unhealthy life style. However, not all arterial plaques lead to complications, which can lead to life-threatening events such as stroke and myocardial ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800013
更新日期:2018-12-01 00:00:00
abstract::Cardiomyocytes derived from human pluripotent stem cells are a promising tool for disease modeling, drug compound testing, and cardiac toxicity screening. Bio-image segmentation is a prerequisite step in cardiomyocyte image analysis by digital holography (DH) in microscopic configuration and has provided satisfactory ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800116
更新日期:2018-12-01 00:00:00
abstract::Drowsy driving contributes to ~20% of all traffic accidents worldwide. Onsite monitoring the mental condition of a driver and forewarning may be a preventive solution to reduce occurrence of drowsiness and potential accidents. Functional near-infrared spectroscopy (fNIRS) has been successfully utilized in hemodynamics...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800160
更新日期:2018-12-01 00:00:00
abstract::Optical sectioning endoscopy such as confocal endoscopy offers capabilities to obtain three-dimensional (3D) information from various biological samples by discriminating between the desired in-focus signals and out-of-focus background. However, in general confocal images are formed through point-by-point scanning and...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800010
更新日期:2018-11-01 00:00:00
abstract::Acridine orange (AO) staining is used to diagnose DNA fragmentation status in sperm cells. Interferometric phase microscopy (IPM) is an optical imaging method based on digital holographic microscopy that provides quantitative morphological and refractive index imaging of cells in vitro without the need for staining. W...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800137
更新日期:2018-11-01 00:00:00
abstract::An experimental study of the influence of the conformational change suffered by molecular beacon (MB) probes-upon the biorecognition of nucleic acid target oligonucleotides over evanescent wave photonic sensors-is reported. To this end, high sensitivity photonic sensors based on silicon photonic bandgap (PBG) structur...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800030
更新日期:2018-10-01 00:00:00
abstract::Nacre is a complex biomaterial made of aragonite-tablet bricks and organic mortar that is considerably resilient against breakage. Nacre has been studied with a wide range of laboratory techniques, leading to understanding key fundamentals and informing the creation of bio-inspired materials. In this article, we prese...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800026
更新日期:2018-10-01 00:00:00
abstract::One pertinent complication in bacterial infection is the growth of biofilms, that is, communities of surface-adhered bacteria resilient to antibiotics. Photodynamic inactivation (PDI) has been proposed as an alternative to antibiotic treatment; however, novel techniques complementing standard efficacy measures are req...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800018
更新日期:2018-10-01 00:00:00
abstract::High-resolution deformation measurements in a functionally graded hard tissue such as human dentin are essential to understand the unbound water-loss mediated changes and their role in its mechanical integrity. Yet a whole-field, 3-dimensional (3D) measurement and characterization of fully hydrated dentin in both macr...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700368
更新日期:2018-09-01 00:00:00
abstract::In fluctuation-based optical nanoscopy, investigating high-density labeled subcellular structures with high fidelity has been a significant challenge. In this study, based on super-resolution radial fluctuation (SRRF) microscopy, the joint tagging (JT) strategy is employed to enable fast high-density nanoscopic imagin...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800020
更新日期:2018-09-01 00:00:00
abstract::Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particl...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700329
更新日期:2018-09-01 00:00:00
abstract::Quantitative phase imaging (QPI) is an emerging modality, which enables the identification of abnormalities in tissue based on optical properties. QPI can be applied to any biological specimen due to its label-free imaging capability, but its use in stained tissue is unclear. Here, we study the variability of QPI with...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700402
更新日期:2018-08-01 00:00:00
abstract::In vivo visualization of the human lymphatic system is limited by the mode of delivery of tracing agents, depth of field and size of the area examined, and specificity of the cell markers used to distinguish lymphatic endothelium from the blood vessels and the surrounding tissues. These limitations are particularly pr...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201700117
更新日期:2018-08-01 00:00:00
abstract::Fluctuations in brain water content has attracted increasing interest, particularly as regards studies of the glymphatic system, which is connected with the complex organization of dural lymphatic vessels, responsible for cleaning tissue. Disturbances of glymphatic circulation are associated with several brain disorde...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700123
更新日期:2018-08-01 00:00:00