Noninvasive in vivo glucose detection in human finger interstitial fluid using wavelength-modulated differential photothermal radiometry.

Abstract:

:We present a noninvasive and noncontacting biosensor using Wavelength Modulated Differential Photothermal Radiometry (WM-DPTR) to monitor blood glucose concentration (BGC) through interstitial fluid (ISF) probing in human middle fingers. WM-DPTR works in the interference-free mid-infrared range with differential wavelengths at the peak and baseline of the fundamental glucose molecule absorption band, giving rise to high glucose sensitivity and specificity. In vivo WM-DPTR measurements and simultaneous finger pricking BGC reference measurements were performed on diabetic and nondiabetic volunteers during oral glucose tolerance testing. The measurement results demonstrated high resolution and large dynamic range (~80 deg) change in phase signal in the normal-to-hyperglycemia BGC range (5 mmol/L to higher than 33.2 mmol/L), which were supported by negative control measurements. The immunity to temperature variation of WM-DPTR yields precise and accurate noninvasive glucose measurements in the ISF.

journal_name

J Biophotonics

journal_title

Journal of biophotonics

authors

Guo X,Zhang D,Shojaei-Asanjan K,Sivagurunathan K,Melnikov A,Song P,Mandelis A

doi

10.1002/jbio.201800441

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

e201800441

issue

7

eissn

1864-063X

issn

1864-0648

journal_volume

12

pub_type

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