Abstract:
:Malaria is a life-threatening infectious blood disease affecting humans and other animals caused by parasitic protozoans belonging to the Plasmodium type especially in developing countries. The gold standard method for the detection of malaria is through the microscopic method of chemically treated blood smears. We developed an automated optical spatial coherence tomographic system using a machine learning approach for a fast identification of malaria cells. In this study, 28 samples (15 healthy, 13 malaria infected stages of red blood cells) were imaged by the developed system and 13 features were extracted. We designed a multilevel ensemble-based classifier for the quantitative prediction of different stages of the malaria cells. The proposed classifier was used by repeating k-fold cross validation dataset and achieve a high-average accuracy of 97.9% for identifying malaria infected late trophozoite stage of cells. Overall, our proposed system and multilevel ensemble model has a substantial quantifiable potential to detect the different stages of malaria infection without staining or expert.
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Singla N,Srivastava V,Mehta DSdoi
10.1002/jbio.201700279subject
Has Abstractpub_date
2018-05-01 00:00:00pages
e201700279issue
5eissn
1864-063Xissn
1864-0648journal_volume
11pub_type
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