Photoacoustic microscopy for evaluating a lipopolysaccharide-induced inflammation model in mice.

Abstract:

:Photoacoustic microscopy (PAM) is a noninvasive imaging technique and is excellent to study structural and functional changes in the microcirculation. In this work, a lipopolysaccharide (LPS)-induced inflammation model in mice is noninvasively evaluated by PAM. PAM is used to image the microvascular structural changes in mice for 8 hours after the LPS with different concentrations is applied. Quantitative analysis of five vessel parameters is conducted, which shows that the rate of reduction in microvasculature is highly dependent on the applied LPS concentrations. For low-concentration LPS, changes in the microvasculature are not obvious over the observation period, whereas for high-concentration LPS, quick and marked reduction in the microvasculature is observed. In addition, changes in capillaries are more significant than those in relatively large vessels. The results show that PAM is able to evaluate the inflammation mouse model by studying structural (and potentially functional) changes in the microcirculation. Furthermore, PAM may have potential for early intervention and treatment plan optimization of sepsis by monitoring the microcirculation and inflammatory response.

journal_name

J Biophotonics

journal_title

Journal of biophotonics

authors

Guo Z,Li Z,Deng Y,Chen SL

doi

10.1002/jbio.201800251

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

e201800251

issue

3

eissn

1864-063X

issn

1864-0648

journal_volume

12

pub_type

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