Heterodyne detected nonlinear optical imaging in a lock-in free manner.

abstract：:For the screening purposes urine is an especially attractive biofluid, since it offers easy and noninvasive sample collection and provides a snapshot of the whole metabolic status of the organism, which may change under different pathological conditions. Raman spectroscopy (RS) has the potential to monitor these chang...

journal_title：Journal of biophotonics

authors： Žukovskaja O,Ryabchykov O,Straßburger M,Heinekamp T,Brakhage AA,Hennings CJ,Hübner CA,Wegmann M,Cialla-May D,Bocklitz TW,Weber K,Popp J

更新日期：2020-01-01 00:00:00

abstract：:Optical coherence tomography (OCT) imaging shows a significant potential in clinical routines due to its noninvasive property. However, the quality of OCT images is generally limited by inherent speckle noise of OCT imaging and low sampling rate. To obtain high signal-to-noise ratio (SNR) and high-resolution (HR) OCT ...

journal_title：Journal of biophotonics

authors： Qiu B,You Y,Huang Z,Meng X,Jiang Z,Zhou C,Liu G,Yang K,Ren Q,Lu Y

更新日期：2021-01-01 00:00:00

abstract：:The class of PEGylated emulsifiers finds broad application in the pharmaceutical and cosmetic industry. We target on one of the categories of polyethylene glycol (PEG) alkyl ethers with different lipophilic and hydrophilic chain length and aim to examine their effects on the skin comprehensively. In this study, we emp...

journal_title：Journal of biophotonics

authors： Liu Y,Lunter DJ

更新日期：2020-12-01 00:00:00

abstract：:We have developed a reflection-mode switchable subwavelength Bessel-beam (BB) and Gaussian-beam (GB) photoacoustic microscopy (PAM) system. To achieve both reflection-mode and high resolution, we tightly attached a very small ultrasound transducer to an optical objective lens with numerical aperture of 1.0 and working...

journal_title：Journal of biophotonics

authors： Park B,Lee H,Jeon S,Ahn J,Kim HH,Kim C

更新日期：2019-02-01 00:00:00

abstract：:Atherosclerosis (AS), the leading cause of morbidity and mortality in cardiovascular disease, needs an early detection for treatment and prevention of fatal events. Here, for the first time, we applied gold nanorods (GNRs)-assisted diffusion reflection (DR), a noninvasive technique for in vivo detection of AS in a hig...

journal_title：Journal of biophotonics

authors： Chakraborty R,Ankri R,Leshem-Lev D,Hochhauser E,Kornowski R,Motiei M,Lev EI,Fixler D

更新日期：2019-01-01 00:00:00

abstract：:Lasers/LEDs demonstrate therapeutic effects for a range of biomedical applications. However, a consensus on effective light irradiation parameters and efficient and reliable measurement techniques remain limited. The objective here is to develop, characterise and demonstrate the application of LED arrays in order to p...

journal_title：Journal of biophotonics

authors： Hadis MA,Cooper PR,Milward MR,Gorecki PC,Tarte E,Churm J,Palin WM

更新日期：2017-11-01 00:00:00

abstract：:Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of diffe...

journal_title：Journal of biophotonics

authors： Persson H,Potrzebowski W,Potrzebowska K,Svensson LM

更新日期：2019-03-01 00:00:00

abstract：:One of the challenges in transcranial low-level laser therapy (LLLT) is to optimally choose illumination parameters, such as wavelength. However, there is sparse study on the wavelengths comparison especially on human transcranial LLLT. Here, we employed Monte Carlo modeling and visible human phantom to compute the pe...

journal_title：Journal of biophotonics

authors： Wang P,Li T

更新日期：2019-02-01 00:00:00

abstract：:For a precise manipulation of particles and cells with laser light as well as for the understanding and the control of the underlying processes it is important to visualize and quantify the response of the specimens. Thus, we investigated if digital holographic microscopy (DHM) can be used in combination with microflu...

journal_title：Journal of biophotonics

authors： Kemper B,Langehanenberg P,Höink A,von Bally G,Wottowah F,Schinkinger S,Guck J,Käs J,Bredebusch I,Schnekenburger J,Schütze K

更新日期：2010-07-01 00:00:00

abstract：:In the current clinical care practice, Gleason grading system is one of the most powerful prognostic predictors for prostate cancer (PCa). The grading system is based on the architectural pattern of cancerous epithelium in histological images. However, the standard procedure of histological examination often involves ...

journal_title：Journal of biophotonics

authors： Yang Q,Xu Z,Liao C,Cai J,Huang Y,Chen H,Tao X,Huang Z,Chen J,Dong J,Zhu X

更新日期：2020-02-01 00:00:00

abstract：:A simple scheme for multimodal coherent anti-Stokes Raman scattering (CARS) microscopy is based on the spectral focusing of ultrafast-oscillator-derived pump/probe light and synchronous photonic crystal fiber (PCF) fiber-generated broadband Stokes light. To date, such schemes allowed rapid hyperspectral imaging throug...

journal_title：Journal of biophotonics

authors： Pegoraro AF,Slepkov AD,Ridsdale A,Moffatt DJ,Stolow A

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to evaluate thermal and near-infrared (NIR) reflectance imaging methods for the assessment of the activity of root caries lesions. In addition, changes in the lesion structure were monitored with polarization sensitive optical coherence tomography (PS-OCT). Artificial bovine and natural r...

journal_title：Journal of biophotonics

authors： Lee RC,Darling CL,Staninec M,Ragadio A,Fried D

更新日期：2017-03-01 00:00:00

abstract：:Currently, the targeted treatment of tumor based on the tumor microenvironment is newly developed. Blood vessels are the key parts in the tumor microenvironment, which is taken as a new visible target for tumor therapy. Multiphoton microscopy (MPM), based on the second harmonic generation and two-photon excited fluore...

journal_title：Journal of biophotonics

authors： Fang N,Wu Z,Wang X,Kang D,Li L,Chen Y,Zheng X,Cai S,Liu X,Chen Z,Tu H,Lin Y,Chen J

更新日期：2019-09-01 00:00:00

abstract：:Optical sectioning endoscopy such as confocal endoscopy offers capabilities to obtain three-dimensional (3D) information from various biological samples by discriminating between the desired in-focus signals and out-of-focus background. However, in general confocal images are formed through point-by-point scanning and...

journal_title：Journal of biophotonics

authors： Lin WT,Lin CY,Singh VR,Luo Y

更新日期：2018-11-01 00:00:00

abstract：:Dynamic follow-up of exogenous molecules permeation through the skin is one among many competing applications for confocal Raman microspectroscopy. Previous studies showed the feasibility of tracking actives through the skin; the next step should be recording in vivo kinetics. Thus, we conducted a study to evaluate th...

journal_title：Journal of biophotonics

authors： Tfaili S,Josse G,Angiboust JF,Manfait M,Piot O

更新日期：2014-09-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In thi...

journal_title：Journal of biophotonics

authors： Zhang J,Liu J,Wang LM,Li ZY,Yuan Z

更新日期：2017-06-01 00:00:00

abstract：:The structural organization of cellular membranes has an essential influence on their functionality. The membrane surfaces currently are considered to consist of various distinct patches, which play an important role in many processes, however, not all parameters such as size and distribution are fully determined. In ...

journal_title：Journal of biophotonics

authors： Deckert-Gaudig T,Böhme R,Freier E,Sebesta A,Merkendorf T,Popp J,Gerwert K,Deckert V

更新日期：2012-07-01 00:00:00

abstract：:Acridine orange (AO) staining is used to diagnose DNA fragmentation status in sperm cells. Interferometric phase microscopy (IPM) is an optical imaging method based on digital holographic microscopy that provides quantitative morphological and refractive index imaging of cells in vitro without the need for staining. W...

journal_title：Journal of biophotonics

authors： Barnea I,Karako L,Mirsky SK,Levi M,Balberg M,Shaked NT

更新日期：2018-11-01 00:00:00

abstract：:Bacterial meningitis is a disease of pronounced clinical significance, especially in the developing world. Immediate treatment with antibiotics is essential, and no single test can provide a conclusive diagnosis. It is well established that elevated total protein in cerebrospinal fluid (CSF) is associated with bacteri...

journal_title：Journal of biophotonics

authors： Steelman Z,Meng Z,Traverso AJ,Yakovlev VV

更新日期：2015-05-01 00:00:00

abstract：:The advent of moderate dilatations in ascending aortas is often accompanied by structural modifications of the main components of the aortic tissue, elastin and collagen. In this study, we have undertaken an approach based on FTIR microscopy coupled to a curve-fitting procedure to analyze secondary structure modificat...

journal_title：Journal of biophotonics

authors： Bonnier F,Rubin S,Debelle L,Ventéo L,Pluot M,Baehrel B,Manfait M,Sockalingum GD

更新日期：2008-08-01 00:00:00

abstract：:Low-power laser irradiation (LPLI) has been extensively employed to modulate inflammation in vitro and in vivo. Previous reports from our group indicated that LPLI might regulate glycemia in diabetic animals. Diabetes results in chronic hyperglycemia and therefore chronic inflammation by upregulation of inflammatory m...

journal_title：Journal of biophotonics

authors： Fukuoka CY,Torres Schröter G,Nicolau J,Simões A

更新日期：2016-12-01 00:00:00

abstract：:In this paper we introduce a custom scanning near-field optical microscope (SNOM) that simultaneously collects reflection and transmission near-field images along with topography. This dual-optical SNOM uses a bent probe, which allows for axial reflection imaging, accurate surface scanning, and easy identification of ...

journal_title：Journal of biophotonics

authors： Kyle JR,Kyle MD,Raghavan R,Budak G,Ozkan CS,Ozkan M

更新日期：2011-03-01 00:00:00

abstract：:Retinoblastoma (RB) is a rare form of cancer of the retina most prevalent in young children. We successfully show that laser-induced cell disruption, mediated by gold plasmonic nanoparticle (NP), is a potential and efficient therapy to kill the cancerous cells. The proof of concept is demonstrated in vitro on cultured...

journal_title：Journal of biophotonics

authors： Darviot C,Hardy P,Meunier M

更新日期：2019-11-01 00:00:00

abstract：:Therapeutically exploiting vascular and metabolic endpoints becomes critical to translational cancer studies because altered vascularity and deregulated metabolism are two important cancer hallmarks. The metabolic and vascular phenotypes of three sibling breast tumor lines with different metastatic potential are inves...

journal_title：Journal of biophotonics

authors： Zhu C,Li M,Vincent T,Martin HL,Crouch BT,Martinez AF,Madonna MC,Palmer GM,Dewhirst MW,Ramanujam N

更新日期：2019-04-01 00:00:00

abstract：:Since stimulated emission depletion (STED) nanoscopy was invented in 1994, this technique has been widely used in the fields of biomedicine and materials science. According to the imaging principle of STED technology, increasing the power of the depletion laser within a certain threshold can improve the resolution. Ho...

journal_title：Journal of biophotonics

authors： Wang J,Wang L,Zhang J,Yang Z,Yan W,Qu J

更新日期：2020-12-13 00:00:00

abstract：:In vivo visualization of the human lymphatic system is limited by the mode of delivery of tracing agents, depth of field and size of the area examined, and specificity of the cell markers used to distinguish lymphatic endothelium from the blood vessels and the surrounding tissues. These limitations are particularly pr...

journal_title：Journal of biophotonics

authors： Lokmic Z

更新日期：2018-08-01 00:00:00

abstract：:Ectasia after refractive surgery represents a major concern among refractive surgeons. Corneal abnormalities and preexisting corneal ectasia are the most important risk factors. Corneal topography and central corneal thickness are the factors traditionally screening for in refractive surgery candidates. Study of the a...

journal_title：Journal of biophotonics

authors： Luz A,Lopes B,Salomão M,Ambrósio R

更新日期：2016-05-01 00:00:00

abstract：:Photoacoustic imaging (PAI) is a hybrid imaging modality with high resolution and sensitivity that can be beneficial for cancer staging. Due to insufficient endogenous photoacoustic (PA) contrast, the development of exogenous agents is critical in targeting cancerous tumors. The current study demonstrates the feasibil...

journal_title：Journal of biophotonics

authors： Nguyen VP,Park S,Oh J,Wook Kang H

更新日期：2017-08-01 00:00:00

abstract：:The investigation of lung dynamics on alveolar scale is crucial for the understanding and treatment of lung diseases, such as acute lung injury and ventilator induced lung injury, and to promote the development of protective ventilation strategies. One approach to this is the establishment of numerical simulations of ...

journal_title：Journal of biophotonics

authors： Kirsten L,Gaertner M,Schnabel C,Meissner S,Koch E

更新日期：2013-02-01 00:00:00

abstract：:Several studies have demonstrated the potential of cross-polarization optical coherence tomography (CP-OCT) to quantify the severity of early caries lesions (tooth decay) on tooth surfaces. The purpose of this study is to show that 2D images of the lesion depth and the integrated reflectivity can be used to accurately...

journal_title：Journal of biophotonics

authors： Chan KH,Chan AC,Fried WA,Simon JC,Darling CL,Fried D

更新日期：2015-01-01 00:00:00