Abstract:
:A murine model of cutaneous leishmaniasis with green fluorescent protein positive (GFP+) L. major enables the monitoring of parasitic load via measurements of GFP fluorescence intensity, allowing for a faster and more efficient way of monitoring the clinical outcome of photodynamic therapy (PDT). This model may provide new insights on the phototoxic aspects in PDT. Although PDT regimens may be somewhat different in humans, it is expected that the developed model will facilitate the optimization and clinical translation of PDT as a therapy for cutaneous leishmaniasis and the eventual development of topical PDT treatments for other granulomatous infections.
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Latorre-Esteves E,Akilov OE,Rai P,Beverley SM,Hasan Tdoi
10.1002/jbio.201000008subject
Has Abstractpub_date
2010-06-01 00:00:00pages
328-35issue
5-6eissn
1864-063Xissn
1864-0648journal_volume
3pub_type
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