Optical clearing for multiscale biological tissues.

abstract：:FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well-established subject, biomarker identification lacks standards and validation of its methods....

journal_title：Journal of biophotonics

authors： Trevisan J,Park J,Angelov PP,Ahmadzai AA,Gajjar K,Scott AD,Carmichael PL,Martin FL

更新日期：2014-04-01 00:00:00

abstract：:Compared to conventional techniques, Laser surgery procedures provide a number of advantages, but may be associated with an increased risk of iatrogenic damage to important anatomical structures. The type of tissue ablated in the focus spot is unknown. Laser-Induced Breakdown-Spectroscopy (LIBS) has the potential to g...

journal_title：Journal of biophotonics

authors： Rohde M,Mehari F,Klämpfl F,Adler W,Neukam FW,Schmidt M,Stelzle F

更新日期：2017-10-01 00:00:00

abstract：:Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is ...

journal_title：Journal of biophotonics

authors： Steinberg I,Turko N,Levi O,Gannot I,Eyal A

更新日期：2016-09-01 00:00:00

abstract：:Modified nucleoside in urine samples is one of the most common biomarkers for cancer screening. Therefore, we developed a novel detection method for modified nucleoside detection in human urine. In this work, the modified nucleoside from real cancer patient's urine samples was first separated and purified using the af...

journal_title：Journal of biophotonics

authors： Lin X,Wang L,Lin H,Lin D,Lin J,Liu X,Qiu S,Xu Y,Chen G,Feng S

更新日期：2019-04-01 00:00:00

abstract：:We developed an optical imaging method based on a feedback principle in which the specific scan pattern is adapted according to the shape of the sample. The feedback approach produces nanometer-resolved 3D images of very small and moving features in live cells in seconds. We show images of microvilli in live cultured ...

journal_title：Journal of biophotonics

authors： Lanzano L,Digman MA,Fwu P,Giral H,Levi M,Gratton E

更新日期：2011-06-01 00:00:00

abstract：:Infrared spectra obtained from cell or tissue specimen have commonly been observed to involve a significant degree of scattering effects, often Mie scattering, which probably overshadows biochemically relevant spectral information by a nonlinear, nonadditive spectral component in Fourier transform infrared (FTIR) spec...

journal_title：Journal of biophotonics

authors： Raulf AP,Butke J,Menzen L,Küpper C,Großerueschkamp F,Gerwert K,Mosig A

更新日期：2020-12-08 00:00:00

abstract：:The aim of this study is to identify changes in scattering with optical coherence tomography (OCT) and relate these measurements with mitochondrial changes during the initiation of apoptosis. Human retinal pigment epithelial cells were cultured and apoptosis was induced using 10% alcohol. Using the attenuation coeffic...

journal_title：Journal of biophotonics

authors： de Bruin DM,Broekgaarden M,van Gemert MJ,Heger M,de la Rosette JJ,Van Leeuwen TG,Faber DJ

更新日期：2016-09-01 00:00:00

abstract：:Myelin is a key component of the peripheral nervous system, whose structure anomaly in the digital skin is implicated in neuropathy. Here we demonstrate an in vivo labeling and imaging technique, capable of visualizing myelin sheaths deep in the mouse digital skin. Through material characterization, we verify that 3-p...

journal_title：Journal of biophotonics

authors： He C,Deng X,Pan Y,Tong S,Kang J,Li J,Qiu P,Wang K

更新日期：2020-12-01 00:00:00

abstract：:Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air-puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion ...

journal_title：Journal of biophotonics

authors： Jin Z,Chen S,Dai Y,Bao C,Ye S,Zhou Y,Wang Y,Huang S,Wang Y,Shen M,Zhu D,Lu F

更新日期：2020-08-01 00:00:00

abstract：:We present a novel silicon photonic biosensor using phase-shifted Bragg gratings in a slot waveguide. The optical field is concentrated inside the slot region, leading to efficient light-matter interaction. The Bragg gratings are formed with sidewall corrugations on the outside of the waveguide, and a phase shift is i...

journal_title：Journal of biophotonics

authors： Wang X,Flueckiger J,Schmidt S,Grist S,Fard ST,Kirk J,Doerfler M,Cheung KC,Ratner DM,Chrostowski L

更新日期：2013-10-01 00:00:00

abstract：:Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particl...

journal_title：Journal of biophotonics

authors： Rudnitzki F,Feineis S,Rahmanzadeh R,Endl E,Lutz J,Groll J,Hüttmann G

更新日期：2018-09-01 00:00:00

abstract：:As the field of tissue engineering evolves, there will be an increasingly important need to visualize and track the complex dynamic changes that occur within three-dimensional constructs. Optical coherence tomography (OCT), as an emerging imaging technology applied to biological materials, offers a number of significa...

journal_title：Journal of biophotonics

authors： Liang X,Graf BW,Boppart SA

更新日期：2009-11-01 00:00:00

abstract：:We have developed a reflection-mode switchable subwavelength Bessel-beam (BB) and Gaussian-beam (GB) photoacoustic microscopy (PAM) system. To achieve both reflection-mode and high resolution, we tightly attached a very small ultrasound transducer to an optical objective lens with numerical aperture of 1.0 and working...

journal_title：Journal of biophotonics

authors： Park B,Lee H,Jeon S,Ahn J,Kim HH,Kim C

更新日期：2019-02-01 00:00:00

abstract：:The above article from the Journal of Biophotonics, published online on 9 January 2018 in Wiley Online Library as Early View (https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201700354), and in Volume 11, e201700354, has been retracted by agreement between the authors (Hong Zhong, Lin Lu, Yuanhao Wang, Hongxing Ya...

journal_title：Journal of biophotonics

authors：

更新日期：2020-04-01 00:00:00

abstract：:Quantitative phase imaging (QPI) is an emerging modality, which enables the identification of abnormalities in tissue based on optical properties. QPI can be applied to any biological specimen due to its label-free imaging capability, but its use in stained tissue is unclear. Here, we study the variability of QPI with...

journal_title：Journal of biophotonics

authors： Ban S,Min E,Ahn Y,Popescu G,Jung W

更新日期：2018-08-01 00:00:00

abstract：:Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of skin fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may ...

journal_title：Journal of biophotonics

authors： Mamalis A,Koo E,Garcha M,Murphy WJ,Isseroff RR,Jagdeo J

更新日期：2016-12-01 00:00:00

abstract：:223 Radium (223 Ra) is widely used in nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice 223 Ra cannot be imaged directly; however, gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work, we show that 223 Ra ...

journal_title：Journal of biophotonics

authors： Boschi F,De Sanctis F,Spinelli AE

更新日期：2018-04-01 00:00:00

abstract：:Photodynamic inactivation of bacteria (PDIB) is considered a new approach for the struggle against multiresistant bacteria. To achieve a sufficient level of bacteria killing, the photosensitizer must attach to and/or penetrate the bacteria and generate a sufficiently high amount of singlet oxygen. To optimize PDIB, th...

journal_title：Journal of biophotonics

authors： Regensburger J,Maisch T,Felgenträger A,Santarelli F,Bäumler W

更新日期：2010-06-01 00:00:00

abstract：:The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolariz...

journal_title：Journal of biophotonics

authors： Gladkova N,Streltsova O,Zagaynova E,Kiseleva E,Gelikonov V,Gelikonov G,Karabut M,Yunusova K,Evdokimova O

更新日期：2011-08-01 00:00:00

abstract：:For the screening purposes urine is an especially attractive biofluid, since it offers easy and noninvasive sample collection and provides a snapshot of the whole metabolic status of the organism, which may change under different pathological conditions. Raman spectroscopy (RS) has the potential to monitor these chang...

journal_title：Journal of biophotonics

authors： Žukovskaja O,Ryabchykov O,Straßburger M,Heinekamp T,Brakhage AA,Hennings CJ,Hübner CA,Wegmann M,Cialla-May D,Bocklitz TW,Weber K,Popp J

更新日期：2020-01-01 00:00:00

abstract：:We investigate the optical wavelength dependence in quantitative photoacoustic (QPA) assessment of red blood cell (RBC) aggregation and oxygen saturation (sO2 ) during pulsatile blood flow. Experimentally, the pulsatile flow was imaged with a 700 to 900 nm laser using the VevoLAZR. Theoretically, the photoacoustic (PA...

journal_title：Journal of biophotonics

authors： Bok TH,Hysi E,Kolios MC

更新日期：2018-08-01 00:00:00

abstract：:A murine model of cutaneous leishmaniasis with green fluorescent protein positive (GFP+) L. major enables the monitoring of parasitic load via measurements of GFP fluorescence intensity, allowing for a faster and more efficient way of monitoring the clinical outcome of photodynamic therapy (PDT). This model may provid...

journal_title：Journal of biophotonics

authors： Latorre-Esteves E,Akilov OE,Rai P,Beverley SM,Hasan T

更新日期：2010-06-01 00:00:00

abstract：:One pertinent complication in bacterial infection is the growth of biofilms, that is, communities of surface-adhered bacteria resilient to antibiotics. Photodynamic inactivation (PDI) has been proposed as an alternative to antibiotic treatment; however, novel techniques complementing standard efficacy measures are req...

journal_title：Journal of biophotonics

authors： Thomsen H,Graf FE,Farewell A,Ericson MB

更新日期：2018-10-01 00:00:00

abstract：:This paper comments on the article "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" by Qian Li et al. The authors propose a method to determine the pulse wave velocity in retinal arteries and veins. This method should enable a noninvasive determination of biomechanical prope...

journal_title：Journal of biophotonics

authors： Spahr H,Hillmann D,Pfäffle C,Hüttmann G

更新日期：2018-02-01 00:00:00

abstract：:Nanofluidics enables the imaging of stretched single molecules with potential applications for single molecule sequence mapping. Lab-on-a-chip devices for single cell trapping and lyzing, genomic DNA extraction from single cells, and optical mapping of genomic length DNA has been demonstrated separately. Yet the pursu...

journal_title：Journal of biophotonics

authors： Marie R,Kristensen A

更新日期：2012-08-01 00:00:00

abstract：:An experimental study of the influence of the conformational change suffered by molecular beacon (MB) probes-upon the biorecognition of nucleic acid target oligonucleotides over evanescent wave photonic sensors-is reported. To this end, high sensitivity photonic sensors based on silicon photonic bandgap (PBG) structur...

journal_title：Journal of biophotonics

authors： Ruiz-Tórtola Á,Prats-Quílez F,González-Lucas D,Bañuls MJ,Maquieira Á,Wheeler G,Dalmay T,Griol A,Hurtado J,Bohlmann H,Götzen R,García-Rupérez J

更新日期：2018-10-01 00:00:00

abstract：:The purpose of this study was to evaluate the tomographic features of postrefractive surgery eyes. This was a retrospective evaluation of clinical data. Three patients with post-LASIK (laser-assisted in situ keratomileusis) and two patients with post-SMILE (small incision lenticule extraction) ectasia were imaged with...

journal_title：Journal of biophotonics

authors： Khamar P,Dalal R,Chandapura R,Francis M,Shetty R,Nelson EJR,Nuijts RMMA,Sinha Roy A

更新日期：2019-02-01 00:00:00

abstract：:The effect of cetyl-trimethylammonium bromide (CTAB) on enhancing the fluorescence resonance energy transfer (FRET) between two dye-conjugated DNA strands was studied using fluorescence emission spectroscopy and dynamic light scattering (DLS). For hybridized DNA where one strand is conjugated with a TAMRA donor and th...

journal_title：Journal of biophotonics

authors： Oh T,Takahashi T,Kim S,Heller MJ

更新日期：2016-01-01 00:00:00

abstract：:Acridine orange (AO) staining is used to diagnose DNA fragmentation status in sperm cells. Interferometric phase microscopy (IPM) is an optical imaging method based on digital holographic microscopy that provides quantitative morphological and refractive index imaging of cells in vitro without the need for staining. W...

journal_title：Journal of biophotonics

authors： Barnea I,Karako L,Mirsky SK,Levi M,Balberg M,Shaked NT

更新日期：2018-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and treatment that would completely eradicate the virus in infected individuals, th...

journal_title：Journal of biophotonics

authors： Lugongolo MY,Manoto SL,Ombinda-Lemboumba S,Maaza M,Mthunzi-Kufa P

更新日期：2017-10-01 00:00:00