Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption.

abstract：:Retinoblastoma (RB) is a rare form of cancer of the retina most prevalent in young children. We successfully show that laser-induced cell disruption, mediated by gold plasmonic nanoparticle (NP), is a potential and efficient therapy to kill the cancerous cells. The proof of concept is demonstrated in vitro on cultured...

journal_title：Journal of biophotonics

authors： Darviot C,Hardy P,Meunier M

更新日期：2019-11-01 00:00:00

abstract：:The broad range of applications of spatially-offset Raman spectroscopy (SORS) were found to involve samples having only marginal differences in Raman cross-sections between the surface and subsurface targets. We report the results of a feasibility study to evaluate the potential of the approach to identify the presenc...

journal_title：Journal of biophotonics

authors： Khan KM,Dutta SB,Krishna H,Majumder SK

更新日期：2016-09-01 00:00:00

abstract：:Despite an ever increasing demand for reliable and cheap methods in the detection and quantification of microbes, surprisingly few investigations have explored or utilized the luminescence of rare earths in the microbial context, neither in conventional, that is, plating and microscopic imaging techniques, nor in adva...

journal_title：Journal of biophotonics

authors： Lezhnina MM,Rochowiak W,Göhde W,Kuczius R,Kynast U

更新日期：2020-09-01 00:00:00

abstract：:Single-molecule localisation based super-resolution fluorescence imaging produces maps of the coordinates of fluorescent molecules in a region of interest. Cluster analysis algorithms provide information concerning the clustering characteristics of these molecules, often through the generation of cluster heat maps bas...

journal_title：Journal of biophotonics

authors： Griffié J,Boelen L,Burn G,Cope AP,Owen DM

更新日期：2015-11-01 00:00:00

abstract：:Optical coherence elastography (OCE) represents the frontier of optical elasticity imaging techniques and focuses on the micro-scale assessment of tissue biomechanics in 3D that is hard to achieve with traditional elastographic methods. Benefit from the advancement of optical coherence tomography, and driven by the in...

journal_title：Journal of biophotonics

authors： Wang S,Larin KV

更新日期：2015-04-01 00:00:00

abstract：:Hyperspectral imaging is a promising technique for resection margin assessment during cancer surgery. Thereby, only a specific amount of the tissue below the resection surface, the clinically defined margin width, should be assessed. Since the imaging depth of hyperspectral imaging varies with wavelength and tissue co...

journal_title：Journal of biophotonics

authors： Kho E,de Boer LL,Post AL,Van de Vijver KK,Jóźwiak K,Sterenborg HJCM,Ruers TJM

更新日期：2019-11-01 00:00:00

abstract：:Spahr et al. recently commented on our latest paper "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" with a conclusion that the measured retinal pulse wave velocity (rPWV) in our paper was contradictory to theoretical predictions and previously published results. However, th...

journal_title：Journal of biophotonics

authors： Li Q,Li L,Chai X,Zhou C

更新日期：2018-02-01 00:00:00

abstract：:The use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore co...

journal_title：Journal of biophotonics

authors： Gu J,Fu CY,Ng BK,Gulam Razul Ss,Lim SK

更新日期：2014-07-01 00:00:00

abstract：:In preclinical researches, bioluminescence tomography (BLT) has widely been used for tumor imaging and monitoring, imaged-guided tumor therapy, and so forth. For these biological applications, both tumor spatial location and morphology analysis are the leading problems needed to be taken into account. However, most ex...

journal_title：Journal of biophotonics

authors： Guo H,Gao L,Yu J,He X,Wang H,Zheng J,Yang X

更新日期：2020-04-01 00:00:00

abstract：:Photoacoustic microscopy (PAM) provides a fundamentally new tool for a broad range of studies of biological structures and functions. However, the use of PAM has been largely limited to small vertebrates due to the large size/weight and the inconvenience of the equipment. Here, we describe a portable optical-resolutio...

journal_title：Journal of biophotonics

authors： Jin T,Guo H,Yao L,Xie H,Jiang H,Xi L

更新日期：2018-04-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In thi...

journal_title：Journal of biophotonics

authors： Zhang J,Liu J,Wang LM,Li ZY,Yuan Z

更新日期：2017-06-01 00:00:00

abstract：:The ability to resolve multiple fluorescent emissions from different biological targets in video rate applications, such as endoscopy and intraoperative imaging, has traditionally been limited by the use of filter-based imaging systems. Hyperspectral imaging (HSI) facilitates the detection of both spatial and spectral...

journal_title：Journal of biophotonics

authors： Luthman AS,Dumitru S,Quiros-Gonzalez I,Joseph J,Bohndiek SE

更新日期：2017-06-01 00:00:00

abstract：:Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of skin fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may ...

journal_title：Journal of biophotonics

authors： Mamalis A,Koo E,Garcha M,Murphy WJ,Isseroff RR,Jagdeo J

更新日期：2016-12-01 00:00:00

abstract：:Low-level laser therapy (LLLT) is known to enhance mitochondrial electron transfer and ATP production; thus, this study asked whether LLLT could stimulate the oxidative burst in human neutrophils (PMN) and improve their ability to kill microorganisms. Blood from healthy human subjects was collected and PMN were isolat...

journal_title：Journal of biophotonics

authors： Cerdeira CD,Lima Brigagão MR,Carli ML,de Souza Ferreira C,de Oliveira Isac Moraes G,Hadad H,Costa Hanemann JA,Hamblin MR,Sperandio FF

更新日期：2016-12-01 00:00:00

abstract：:Stimulated Raman scattering (SRS) has been applied to unstained samples of articular cartilage enabling the investigation of living cells within fresh tissue. Hyperspectral SRS measurements over the CH vibrational region showed variations in protein and lipid content within the cells, pericellular matrix and interterr...

journal_title：Journal of biophotonics

authors： Mansfield J,Moger J,Green E,Moger C,Winlove CP

更新日期：2013-10-01 00:00:00

abstract：:We developed an optical imaging method based on a feedback principle in which the specific scan pattern is adapted according to the shape of the sample. The feedback approach produces nanometer-resolved 3D images of very small and moving features in live cells in seconds. We show images of microvilli in live cultured ...

journal_title：Journal of biophotonics

authors： Lanzano L,Digman MA,Fwu P,Giral H,Levi M,Gratton E

更新日期：2011-06-01 00:00:00

abstract：:Bacterial meningitis is a disease of pronounced clinical significance, especially in the developing world. Immediate treatment with antibiotics is essential, and no single test can provide a conclusive diagnosis. It is well established that elevated total protein in cerebrospinal fluid (CSF) is associated with bacteri...

journal_title：Journal of biophotonics

authors： Steelman Z,Meng Z,Traverso AJ,Yakovlev VV

更新日期：2015-05-01 00:00:00

abstract：:An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enablin...

journal_title：Journal of biophotonics

authors： Zhao Y,Graf BW,Chaney EJ,Mahmassani Z,Antoniadou E,Devolder R,Kong H,Boppart MD,Boppart SA

更新日期：2012-05-01 00:00:00

abstract：:Fluctuations in brain water content has attracted increasing interest, particularly as regards studies of the glymphatic system, which is connected with the complex organization of dural lymphatic vessels, responsible for cleaning tissue. Disturbances of glymphatic circulation are associated with several brain disorde...

journal_title：Journal of biophotonics

authors： Myllylä T,Harju M,Korhonen V,Bykov A,Kiviniemi V,Meglinski I

更新日期：2018-08-01 00:00:00

abstract：:Articular cartilage posesses unique material properties due to a complex depth-dependent composition of sub-components. Raman spectroscopy has proven valuable in quantifying this composition through cartilage cross-sections. However, cross-sectioning requires tissue destruction and is not practical in situ. In this wo...

journal_title：Journal of biophotonics

authors： Mason D,Murugkar S,Speirs AD

更新日期：2021-01-01 00:00:00

abstract：:Since stimulated emission depletion (STED) nanoscopy was invented in 1994, this technique has been widely used in the fields of biomedicine and materials science. According to the imaging principle of STED technology, increasing the power of the depletion laser within a certain threshold can improve the resolution. Ho...

journal_title：Journal of biophotonics

authors： Wang J,Wang L,Zhang J,Yang Z,Yan W,Qu J

更新日期：2020-12-13 00:00:00

abstract：:Bone-marrow (BM)-derived cells have been shown to be capable of aiding skin regeneration in vivo by differentiating into keratinocytes. However, the conditions under which this occurs are not fully understood. Characterizing innate mechanisms of skin regeneration by stem cells in vivo is important for the area of stem...

journal_title：Journal of biophotonics

authors： Graf BW,Bower AJ,Chaney EJ,Marjanovic M,Adie SG,De Lisio M,Valero MC,Boppart MD,Boppart SA

更新日期：2014-01-01 00:00:00

abstract：:A novel hybrid method which combines sub-wavelength-scale phase measurements and pixel-scale displacement tracking for robust strain mapping in compressional optical coherence elastography is proposed. Unlike majority of OCE methods it does not rely on initial reconstruction of displacements and does not suffer from t...

journal_title：Journal of biophotonics

authors： Zaitsev VY,Matveyev AL,Matveev LA,Gelikonov GV,Gubarkova EV,Gladkova ND,Vitkin A

更新日期：2016-05-01 00:00:00

abstract：:Intravascular optical coherence tomography (IV-OCT) is a light-based imaging modality with high resolution, which employs near-infrared light to provide tomographic intracoronary images. Morbidity caused by coronary heart disease is a substantial cause of acute coronary syndrome and sudden cardiac death. The most comm...

journal_title：Journal of biophotonics

authors： Abdolmanafi A,Cheriet F,Duong L,Ibrahim R,Dahdah N

更新日期：2020-01-01 00:00:00

abstract：:Photoacoustic microscopy (PAM) is a noninvasive imaging technique and is excellent to study structural and functional changes in the microcirculation. In this work, a lipopolysaccharide (LPS)-induced inflammation model in mice is noninvasively evaluated by PAM. PAM is used to image the microvascular structural changes...

journal_title：Journal of biophotonics

authors： Guo Z,Li Z,Deng Y,Chen SL

更新日期：2019-03-01 00:00:00

abstract：:Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. Here, we develop and compare different approaches for developing Raman classification algorithms to diagnose invasive and in situ breast cancer, fibrocystic change and fibroadenoma that can be associ...

journal_title：Journal of biophotonics

authors： Dingari NC,Barman I,Saha A,McGee S,Galindo LH,Liu W,Plecha D,Klein N,Dasari RR,Fitzmaurice M

更新日期：2013-04-01 00:00:00

abstract：:Osteocytes are the most abundant cells in bone and always the focus of bone research. They are embedded in the highly scattering mineralized bone matrix. Consequently, visualizing osteocytes deep in bone with subcellular resolution poses a major challenge for in vivo bone research. Here we overcome this challenge by d...

journal_title：Journal of biophotonics

authors： Wang K,Du Y,Liu H,Gan M,Tong S,Wen W,Zhuang Z,Qiu P

更新日期：2019-04-01 00:00:00

abstract：:Laser therapy, also known as Photobiomodulation (PBM) is indicated to reduce pain associated with different pathologies and applied using protocols that vary in wavelength, irradiance and fluence. Its mechanisms of action are still unclear and possibly able to directly impact on pain transmission, reducing nociceptor ...

journal_title：Journal of biophotonics

authors： Zupin L,Ottaviani G,Rupel K,Biasotto M,Zacchigna S,Crovella S,Celsi F

更新日期：2019-10-01 00:00:00

abstract：:The purpose of this study was to evaluate early vascular and tomographic changes in the retina of diabetic patients using artificial intelligence (AI). The study included 74 age-matched normal eyes, 171 diabetic eyes without retinopathy (DWR) eyes and 69 mild non-proliferative diabetic retinopathy (NPDR) eyes. All pat...

journal_title：Journal of biophotonics

authors： Govindaswamy N,Ratra D,Dalan D,Doralli S,Tirumalai AA,Nagarajan R,Mochi T,Shetty N,Sinha Roy A

更新日期：2020-09-01 00:00:00

abstract：:Solar radiation exposure is recognised to be a significant contributor to the development of skin cancer. Monitoring the simultaneous and consecutive mechanisms of interaction could provide a greater understanding of the process of photocarcinogenesis. This work presents an analysis of the biochemical and morphologica...

journal_title：Journal of biophotonics

authors： Lopez-Gonzalez U,Casey A,J Byrne H

更新日期：2020-10-24 00:00:00