Abstract:
:The purpose of this study was to evaluate the tomographic features of postrefractive surgery eyes. This was a retrospective evaluation of clinical data. Three patients with post-LASIK (laser-assisted in situ keratomileusis) and two patients with post-SMILE (small incision lenticule extraction) ectasia were imaged with Scheimpflug imaging (SI, Pentacam) and optical coherence tomography (OCT, RTVue). Curvature and wavefront aberrations of the air-epithelium interface (A-E) and epithelium-Bowman's layer interface (E-B) were derived. OCT of normal and keratoconic eyes from an earlier study were compared with the data of the ectasia eyes. Curvature and aberrometry of the A-E interfaces were statistically similar between SI and OCT. However, OCT revealed a steeper and more aberrated E-B interface than A-E though correlation between them was inferior to the correlation for keratoconic eyes. Furthermore, the magnitude of differences between the A-E and E-B interfaces was greater in the ectasia eyes than the keratoconic eyes. OCT could possibly assist better in selecting appropriate treatment plan for postrefractive surgery ectasia eyes than conventional tomographers.
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Khamar P,Dalal R,Chandapura R,Francis M,Shetty R,Nelson EJR,Nuijts RMMA,Sinha Roy Adoi
10.1002/jbio.201800253subject
Has Abstractpub_date
2019-02-01 00:00:00pages
e201800253issue
2eissn
1864-063Xissn
1864-0648journal_volume
12pub_type
杂志文章abstract::Optical coherence elastography (OCE) represents the frontier of optical elasticity imaging techniques and focuses on the micro-scale assessment of tissue biomechanics in 3D that is hard to achieve with traditional elastographic methods. Benefit from the advancement of optical coherence tomography, and driven by the in...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201400108
更新日期:2015-04-01 00:00:00
abstract::The aim of this study is to identify changes in scattering with optical coherence tomography (OCT) and relate these measurements with mitochondrial changes during the initiation of apoptosis. Human retinal pigment epithelial cells were cultured and apoptosis was induced using 10% alcohol. Using the attenuation coeffic...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500198
更新日期:2016-09-01 00:00:00
abstract::Micro-/nanosphere-mediated femtosecond laser cell perforation is one of the high throughput technologies used for macro-molecule-delivery into multiple cells. We have demonstrated the delivery of plasmid-DNA/liposome complexes into cells using biodegradable polymer microspheres and a femtosecond laser and investigated...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600323
更新日期:2017-12-01 00:00:00
abstract::It is well known that, under exposure to bright light, eggs tend to hatch earlier than control, without any damage to the birds. This report aims to systematically show the effect and establishes a proposal for a possible application to accelerate chicken egg formation, which could be extrapolated or adapted as a grea...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700046
更新日期:2018-02-01 00:00:00
abstract::Delay-and-sum (DAS) is one of the most common algorithms used to construct the photoacoustic images due to its low complexity. However, it results in images with high sidelobes and low resolution. Delay-and-standard-deviation (DASD) weighting factor can improve the contrast of the images compared to DAS. However, it s...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800292
更新日期:2019-06-01 00:00:00
abstract::A conceptually new type of corneal inlays for a customized treatment of presbyopia is presented. The diffractive inlay consists on a small aperture disc having an array of micro-holes distributed inside the open zones of a Fresnel zone plate. In this way, the central hole of the disc lets pass the zero order diffracti...
journal_title:Journal of biophotonics
pub_type: 信件
doi:10.1002/jbio.201600320
更新日期:2017-09-01 00:00:00
abstract::Laser therapy, also known as Photobiomodulation (PBM) is indicated to reduce pain associated with different pathologies and applied using protocols that vary in wavelength, irradiance and fluence. Its mechanisms of action are still unclear and possibly able to directly impact on pain transmission, reducing nociceptor ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900043
更新日期:2019-10-01 00:00:00
abstract::Diffuse reflectance spectroscopy is a rapidly growing technology in the biophotonics community where it has shown promise in its ability to classify different tissues. In the steady-state domain a wide spectrum of clinical applications is supported with this technology ranging from diagnostic to guided interventions. ...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201300198
更新日期:2015-01-01 00:00:00
abstract::In vivo microscopy has recently become a gold standard in lung immunology studies involving small animals, largely benefiting from the democratization of multiphoton microscopy allowing for deep tissue imaging. This technology represents currently our only way of exploring the lungs and inferring what happens in human...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201500246
更新日期:2016-09-01 00:00:00
abstract::Endoscopy has been widely used in biomedical imaging and integrated with various optical and acoustic imaging modalities. Photoacoustic imaging (PAI), one of the fastest growing biomedical imaging modalities, is a noninvasive and nonionizing method that owns rich optical contrast, deep acoustic penetration depth, mult...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.202000217
更新日期:2020-12-01 00:00:00
abstract::5-aminolevulinic acid (ALA) and its methylated ester (MAL) are the most common topical agents used in photodynamic therapy (PDT) as precursors of the photosensitizer protoporphyrin IX (PpIX). The induction of newly PpIX depends on incubation time of each photosensitizer in the tissue and the presence of high intralesi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600164
更新日期:2016-12-01 00:00:00
abstract::One pertinent complication in bacterial infection is the growth of biofilms, that is, communities of surface-adhered bacteria resilient to antibiotics. Photodynamic inactivation (PDI) has been proposed as an alternative to antibiotic treatment; however, novel techniques complementing standard efficacy measures are req...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800018
更新日期:2018-10-01 00:00:00
abstract::Photodynamic inactivation of bacteria (PDIB) is considered a new approach for the struggle against multiresistant bacteria. To achieve a sufficient level of bacteria killing, the photosensitizer must attach to and/or penetrate the bacteria and generate a sufficiently high amount of singlet oxygen. To optimize PDIB, th...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.200900106
更新日期:2010-06-01 00:00:00
abstract::Acridine orange (AO) staining is used to diagnose DNA fragmentation status in sperm cells. Interferometric phase microscopy (IPM) is an optical imaging method based on digital holographic microscopy that provides quantitative morphological and refractive index imaging of cells in vitro without the need for staining. W...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800137
更新日期:2018-11-01 00:00:00
abstract::Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air-puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000104
更新日期:2020-08-01 00:00:00
abstract::We develop a confocal system equipped with optimal elliptical apertures to improve axial point spread function and signal-to-background ratio (SBR) for different detector sizes. By adjusting the parameters of the elliptical apertures, the axial half width at half-maximum can be reduced to 4.986 (described in optical c...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700293
更新日期:2018-05-01 00:00:00
abstract::Cardiomyocytes derived from human pluripotent stem cells are a promising tool for disease modeling, drug compound testing, and cardiac toxicity screening. Bio-image segmentation is a prerequisite step in cardiomyocyte image analysis by digital holography (DH) in microscopic configuration and has provided satisfactory ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800116
更新日期:2018-12-01 00:00:00
abstract::We developed an optical imaging method based on a feedback principle in which the specific scan pattern is adapted according to the shape of the sample. The feedback approach produces nanometer-resolved 3D images of very small and moving features in live cells in seconds. We show images of microvilli in live cultured ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201100002
更新日期:2011-06-01 00:00:00
abstract::Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of diffe...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800080
更新日期:2019-03-01 00:00:00
abstract::Intravascular optical coherence tomography (IV-OCT) is a light-based imaging modality with high resolution, which employs near-infrared light to provide tomographic intracoronary images. Morbidity caused by coronary heart disease is a substantial cause of acute coronary syndrome and sudden cardiac death. The most comm...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900112
更新日期:2020-01-01 00:00:00
abstract::One of the challenges in transcranial low-level laser therapy (LLLT) is to optimally choose illumination parameters, such as wavelength. However, there is sparse study on the wavelengths comparison especially on human transcranial LLLT. Here, we employed Monte Carlo modeling and visible human phantom to compute the pe...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800173
更新日期:2019-02-01 00:00:00
abstract::Photoacoustic microscopy (PAM) is a noninvasive imaging technique and is excellent to study structural and functional changes in the microcirculation. In this work, a lipopolysaccharide (LPS)-induced inflammation model in mice is noninvasively evaluated by PAM. PAM is used to image the microvascular structural changes...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800251
更新日期:2019-03-01 00:00:00
abstract::Semen analysis is performed for evaluation of fertility disorders, however it is susceptible to subjectivity of investigators, and lacking of objective criterion for sperm cell quality remains a problem. There is an ongoing debate on which criteria should be employed to define normal spermatozoa. Here, the aim of our ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300003
更新日期:2014-09-01 00:00:00
abstract::We present a pseudo-real-time retinal layer segmentation for high-resolution Sensorless Adaptive Optics-Optical Coherence Tomography (SAO-OCT). Our pseudo-real-time segmentation method is based on Dijkstra's algorithm that uses the intensity of pixels and the vertical gradient of the image to find the minimum cost in ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000042
更新日期:2020-08-01 00:00:00
abstract::Photodynamic therapy (PDT) uses photosensitizers and visible light in combination with molecular oxygen to produce reactive oxygen species (ROS) that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature and stimulate the host immune system. The excited singlet state of oxygen (1 O2 )...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201600055
更新日期:2016-12-01 00:00:00
abstract::223 Radium (223 Ra) is widely used in nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice 223 Ra cannot be imaged directly; however, gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work, we show that 223 Ra ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700209
更新日期:2018-04-01 00:00:00
abstract::We have investigated the ability of dual-frequency Coherent Antistokes Raman Scattering (D-CARS) micro-spectroscopy, based on femtosecond pulses (100 fs or 5 fs) spectrally focussed by glass dispersion, to distinguish the chemical composition of micron-sized lipid droplets consisting of different triglycerides types (...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200197
更新日期:2014-01-01 00:00:00
abstract::Light delivery and monitoring during photodynamic therapy (PDT) is often limited by the need for a physical link between the light source, detectors and the treatment volume. This paper reports on the first in vivo experiments performed with a fully implantable telemetric system, designed for a rat glioblastoma model....
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.200900098
更新日期:2010-06-01 00:00:00
abstract::A robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Am...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800333
更新日期:2019-04-01 00:00:00
abstract::In biomedical applications, nanoparticles have demonstrated the potential to eradicate abnormal cells in small localized pathological zones associated with cancer or infections. Here, we introduce a method for nanotechnology-based photothermal (PT) killing of whole organisms considered harmful to humans or the environ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200199
更新日期:2014-07-01 00:00:00