Photosensitized singlet oxygen generation and detection: Recent advances and future perspectives in cancer photodynamic therapy.

abstract：:High-resolution deformation measurements in a functionally graded hard tissue such as human dentin are essential to understand the unbound water-loss mediated changes and their role in its mechanical integrity. Yet a whole-field, 3-dimensional (3D) measurement and characterization of fully hydrated dentin in both macr...

journal_title：Journal of biophotonics

authors： Chen Z,Nadeau B,Yu K,Shao X,He X,Goh MC,Kishen A

更新日期：2018-09-01 00:00:00

abstract：:Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to characteristic increases in dermal fibroblast proliferation and collagen deposition through upregulation in components of the transforming growth factor beta (TGF-B)/SMAD pathway. In contrast to ultraviolet phototherapy, high-fluence...

journal_title：Journal of biophotonics

authors： Mamalis A,Koo E,Tepper C,Jagdeo J

更新日期：2019-05-01 00:00:00

abstract：:A plastic optical fibre biosensor based on surface plasmon resonance for the detection of C-reactive protein (CRP) in serum is proposed. The biosensor was integrated into a home-made thermo-stabilized microfluidic system that allows avoiding any thermal and/or mechanical fluctuation and maintaining the best stable con...

journal_title：Journal of biophotonics

authors： Aray A,Chiavaioli F,Arjmand M,Trono C,Tombelli S,Giannetti A,Cennamo N,Soltanolkotabi M,Zeni L,Baldini F

更新日期：2016-10-01 00:00:00

abstract：:In this work we present how to entirely remove the scattering ambiguity present in existing multiphoton multifocal systems. This is achieved through the development and implementation of single-element detection systems that incorporate high-speed photon-counting electronics. These systems can be used to image entire ...

journal_title：Journal of biophotonics

authors： Hoover EE,Field JJ,Winters DG,Young MD,Chandler EV,Speirs JC,Lapenna JT,Kim SM,Ding SY,Bartels RA,Wang JW,Squier JA

更新日期：2012-05-01 00:00:00

abstract：:The possibilities of using Mueller matrix (MM) imaging polarimetry to assess meat quality have not yet been sufficiently explored. In the current study, the fresh porcine muscles are imaged at room temperature with a wide-field MM imaging polarimeter over 26 hours to visualize dynamics of tissue optical properties thr...

journal_title：Journal of biophotonics

authors： Peyvasteh M,Popov A,Bykov A,Pierangelo A,Novikova T,Meglinski I

更新日期：2020-11-21 00:00:00

abstract：:Modified nucleoside in urine samples is one of the most common biomarkers for cancer screening. Therefore, we developed a novel detection method for modified nucleoside detection in human urine. In this work, the modified nucleoside from real cancer patient's urine samples was first separated and purified using the af...

journal_title：Journal of biophotonics

authors： Lin X,Wang L,Lin H,Lin D,Lin J,Liu X,Qiu S,Xu Y,Chen G,Feng S

更新日期：2019-04-01 00:00:00

abstract：:Cardiomyocytes derived from human pluripotent stem cells are a promising tool for disease modeling, drug compound testing, and cardiac toxicity screening. Bio-image segmentation is a prerequisite step in cardiomyocyte image analysis by digital holography (DH) in microscopic configuration and has provided satisfactory ...

journal_title：Journal of biophotonics

authors： Moon I,Jaferzadeh K,Ahmadzadeh E,Javidi B

更新日期：2018-12-01 00:00:00

abstract：:Basidiomycetes, that is, mushroom-type fungi, are known to produce pigments in response to environmental impacts. As antioxidants with a high level of unsaturation, these compounds can neutralize highly oxidative species. In the event of close contact with other microbes, the enzymatically controlled pigment productio...

journal_title：Journal of biophotonics

authors： Tauber JP,Matthäus C,Lenz C,Hoffmeister D,Popp J

更新日期：2018-06-01 00:00:00

abstract：:Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of skin fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may ...

journal_title：Journal of biophotonics

authors： Mamalis A,Koo E,Garcha M,Murphy WJ,Isseroff RR,Jagdeo J

更新日期：2016-12-01 00:00:00

abstract：:Photodynamic inactivation of bacteria (PDIB) is considered a new approach for the struggle against multiresistant bacteria. To achieve a sufficient level of bacteria killing, the photosensitizer must attach to and/or penetrate the bacteria and generate a sufficiently high amount of singlet oxygen. To optimize PDIB, th...

journal_title：Journal of biophotonics

authors： Regensburger J,Maisch T,Felgenträger A,Santarelli F,Bäumler W

更新日期：2010-06-01 00:00:00

abstract：:The use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore co...

journal_title：Journal of biophotonics

authors： Gu J,Fu CY,Ng BK,Gulam Razul Ss,Lim SK

更新日期：2014-07-01 00:00:00

abstract：:Methods of nonlinear optics provide a vast arsenal of tools for label-free brain imaging, offering a unique combination of chemical specificity, the ability to detect fine morphological features, and an unprecedentedly high, subdiffraction spatial resolution. While these techniques provide a rapidly growing platform f...

journal_title：Journal of biophotonics

authors： Lanin AA,Pochechuev MS,Chebotarev AS,Kelmanson IV,Belousov VV,Zheltikov AM

更新日期：2019-11-01 00:00:00

abstract：:Monitoring living cells in real-time is important in order to unravel complex dynamic processes in life sciences. In particular the dynamics of initiation and progression of degenerative diseases is intensely studied. In atherosclerosis the thickening of arterial walls is related to high lipid levels in the blood stre...

journal_title：Journal of biophotonics

authors： Stiebing C,Meyer T,Rimke I,Matthäus C,Schmitt M,Lorkowski S,Popp J

更新日期：2017-09-01 00:00:00

abstract：:Molecular motors have been extensively studied over the past 25 years using a range of optical microscopy methods. The specific example of RNA polymerase, responsible for transcribing the information encoded in DNA into RNA, illustrates the strength of the convergence between these recent approaches and the vast store...

journal_title：Journal of biophotonics

authors： Strick TR

更新日期：2008-09-01 00:00:00

abstract：:Stimulated Raman scattering (SRS) microscopy is a label-free method generating images based on chemical contrast within samples, and has already shown its great potential for high-sensitivity and fast imaging of biological specimens. The capability of SRS to collect molecular vibrational signatures in bio-samples, cou...

journal_title：Journal of biophotonics

authors： Laptenok SP,Rajamanickam VP,Genchi L,Monfort T,Lee Y,Patel II,Bertoncini A,Liberale C

更新日期：2019-09-01 00:00:00

abstract：:A Monte Carlo simulation was adapted to specify a skin model with pigmented epidermis, dermis with low baseline blood content, and vessels of a vascular lesion with an average added blood volume fraction of 5%. In the study, the lesion vessel diameters were increased and the number of lesion vessels decreased, such th...

journal_title：Journal of biophotonics

authors： Jacques SL

更新日期：2010-01-01 00:00:00

abstract：:This paper comments on the article "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" by Qian Li et al. The authors propose a method to determine the pulse wave velocity in retinal arteries and veins. This method should enable a noninvasive determination of biomechanical prope...

journal_title：Journal of biophotonics

authors： Spahr H,Hillmann D,Pfäffle C,Hüttmann G

更新日期：2018-02-01 00:00:00

abstract：:The advent of moderate dilatations in ascending aortas is often accompanied by structural modifications of the main components of the aortic tissue, elastin and collagen. In this study, we have undertaken an approach based on FTIR microscopy coupled to a curve-fitting procedure to analyze secondary structure modificat...

journal_title：Journal of biophotonics

authors： Bonnier F,Rubin S,Debelle L,Ventéo L,Pluot M,Baehrel B,Manfait M,Sockalingum GD

更新日期：2008-08-01 00:00:00

abstract：:The ability to provide quantitative, objective and automated pathological analysis would provide enormous benefits for national cancer screening programmes, in terms of both resource reduction and improved patient wellbeing. The move towards molecular pathology through spectroscopic methods shows great promise, but ha...

journal_title：Journal of biophotonics

authors： Woolford L,Chen M,Dholakia K,Herrington CS

更新日期：2018-04-01 00:00:00

abstract：:Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca(2+) transients. The higher Ca(2+) peaks were observed at lower laser doses, with the hi...

journal_title：Journal of biophotonics

authors： Paviolo C,Haycock JW,Cadusch PJ,McArthur SL,Stoddart PR

更新日期：2014-10-01 00:00:00

abstract：:The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolariz...

journal_title：Journal of biophotonics

authors： Gladkova N,Streltsova O,Zagaynova E,Kiseleva E,Gelikonov V,Gelikonov G,Karabut M,Yunusova K,Evdokimova O

更新日期：2011-08-01 00:00:00

abstract：:DsRed is representative of the tetrameric reef coral fluorescent proteins that constitute particularly interesting coupled multichromophoric systems. Either a green emitting or a red emitting chromophore can form within each of the monomers of the protein tetramer. Within the tetramers the chromophores are thought to ...

journal_title：Journal of biophotonics

authors： Blum C,Meixner AJ,Subramaniam V

更新日期：2011-01-01 00:00:00

abstract：:We suggest to use a combination of optical tweezers and single-image quantitative differential interference contrast (DIC) emulated by a spatial light modulator (SLM) to study physiological shape changes in thrombocytes after activation and demonstrate the effectiveness of this system for the given task. A specially d...

journal_title：Journal of biophotonics

authors： Khan S,Jesacher A,Nussbaumer W,Bernet S,Ritsch-Marte M

更新日期：2011-09-01 00:00:00

abstract：:Atherosclerosis (AS), the leading cause of morbidity and mortality in cardiovascular disease, needs an early detection for treatment and prevention of fatal events. Here, for the first time, we applied gold nanorods (GNRs)-assisted diffusion reflection (DR), a noninvasive technique for in vivo detection of AS in a hig...

journal_title：Journal of biophotonics

authors： Chakraborty R,Ankri R,Leshem-Lev D,Hochhauser E,Kornowski R,Motiei M,Lev EI,Fixler D

更新日期：2019-01-01 00:00:00

abstract：:Stimulated Raman scattering (SRS) has been applied to unstained samples of articular cartilage enabling the investigation of living cells within fresh tissue. Hyperspectral SRS measurements over the CH vibrational region showed variations in protein and lipid content within the cells, pericellular matrix and interterr...

journal_title：Journal of biophotonics

authors： Mansfield J,Moger J,Green E,Moger C,Winlove CP

更新日期：2013-10-01 00:00:00

abstract：:In photoacoustic tomography (PAT), a tunable laser typically illuminates the tissue at multiple wavelengths, and the received photoacoustic waves are used to form functional images of relative total haemoglobin (rHbT) and blood oxygenation saturation (%sO2 ). Due to measurement errors, the estimation of these paramete...

journal_title：Journal of biophotonics

authors： Amidi E,Yang G,Uddin KMS,Luo H,Middleton W,Powell M,Siegel C,Zhu Q

更新日期：2020-12-30 00:00:00

abstract：:Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection associated with impaired cerebral blood flow. Visualization of the eye vasculature, which is embryologically derived from that of the brain, is used clinically to diagnose the syndrome. Here, we introduce camera-phone laser speckle imagi...

journal_title：Journal of biophotonics

authors： Remer I,Pierre-Destine LF,Tay D,Golightly LM,Bilenca A

更新日期：2019-01-01 00:00:00

abstract：:We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using laser induced optical breakdown. Using an in-house built prototype device, tightly focused near-infrared laser pulses are used to create optical breakdown in t...

journal_title：Journal of biophotonics

authors： Habbema L,Verhagen R,Van Hal R,Liu Y,Varghese B

更新日期：2012-02-01 00:00:00

abstract：:5-aminolevulinic acid (ALA) and its methylated ester (MAL) are the most common topical agents used in photodynamic therapy (PDT) as precursors of the photosensitizer protoporphyrin IX (PpIX). The induction of newly PpIX depends on incubation time of each photosensitizer in the tissue and the presence of high intralesi...

journal_title：Journal of biophotonics

authors： Lima CA,Goulart VP,Bechara EJ,Correa L,Zezell DM

更新日期：2016-12-01 00:00:00

abstract：:Three-dimensional reconstruction of tissue structures is essential for biomedical research. The development of light microscopes and various fluorescent labeling techniques provides powerful tools for this motivation. However, optical imaging depth suffers from strong light scattering due to inherent heterogeneity of ...

journal_title：Journal of biophotonics

authors： Yu T,Qi Y,Gong H,Luo Q,Zhu D

更新日期：2018-02-01 00:00:00