In vivo noninvasive measurement of spatially resolved corneal elasticity in human eyes using Lamb wave optical coherence elastography.

Abstract:

:Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air-puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion and visualize the Lamb wave propagation clearly in healthy subjects. Based on the Lamb wave model, the phase velocity dispersion curve in the high-frequency is calculated to obtain spatially resolved corneal elasticity accurately with high repeatability. It is found that the corneal elasticity has regional variations and is correlated with intraocular pressure, which suggests that the method has the potential to provide noninvasive measurement of spatially resolved corneal elasticity in clinical practice.

journal_name

J Biophotonics

journal_title

Journal of biophotonics

authors

Jin Z,Chen S,Dai Y,Bao C,Ye S,Zhou Y,Wang Y,Huang S,Wang Y,Shen M,Zhu D,Lu F

doi

10.1002/jbio.202000104

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

e202000104

issue

8

eissn

1864-063X

issn

1864-0648

journal_volume

13

pub_type

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