Rapid discrimination of colon cancer cells with single base mutation in KRAS gene segment using laser tweezers Raman spectroscopy.

abstract：:The use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore co...

journal_title：Journal of biophotonics

authors： Gu J,Fu CY,Ng BK,Gulam Razul Ss,Lim SK

更新日期：2014-07-01 00:00:00

abstract：:We present a noninvasive and noncontacting biosensor using Wavelength Modulated Differential Photothermal Radiometry (WM-DPTR) to monitor blood glucose concentration (BGC) through interstitial fluid (ISF) probing in human middle fingers. WM-DPTR works in the interference-free mid-infrared range with differential wavel...

journal_title：Journal of biophotonics

authors： Guo X,Zhang D,Shojaei-Asanjan K,Sivagurunathan K,Melnikov A,Song P,Mandelis A

更新日期：2019-07-01 00:00:00

abstract：:Modified nucleoside in urine samples is one of the most common biomarkers for cancer screening. Therefore, we developed a novel detection method for modified nucleoside detection in human urine. In this work, the modified nucleoside from real cancer patient's urine samples was first separated and purified using the af...

journal_title：Journal of biophotonics

authors： Lin X,Wang L,Lin H,Lin D,Lin J,Liu X,Qiu S,Xu Y,Chen G,Feng S

更新日期：2019-04-01 00:00:00

abstract：:A plastic optical fibre biosensor based on surface plasmon resonance for the detection of C-reactive protein (CRP) in serum is proposed. The biosensor was integrated into a home-made thermo-stabilized microfluidic system that allows avoiding any thermal and/or mechanical fluctuation and maintaining the best stable con...

journal_title：Journal of biophotonics

authors： Aray A,Chiavaioli F,Arjmand M,Trono C,Tombelli S,Giannetti A,Cennamo N,Soltanolkotabi M,Zeni L,Baldini F

更新日期：2016-10-01 00:00:00

abstract：:Molecular motors have been extensively studied over the past 25 years using a range of optical microscopy methods. The specific example of RNA polymerase, responsible for transcribing the information encoded in DNA into RNA, illustrates the strength of the convergence between these recent approaches and the vast store...

journal_title：Journal of biophotonics

authors： Strick TR

更新日期：2008-09-01 00:00:00

abstract：:The class of PEGylated emulsifiers finds broad application in the pharmaceutical and cosmetic industry. We target on one of the categories of polyethylene glycol (PEG) alkyl ethers with different lipophilic and hydrophilic chain length and aim to examine their effects on the skin comprehensively. In this study, we emp...

journal_title：Journal of biophotonics

authors： Liu Y,Lunter DJ

更新日期：2020-12-01 00:00:00

abstract：:Dynamic follow-up of exogenous molecules permeation through the skin is one among many competing applications for confocal Raman microspectroscopy. Previous studies showed the feasibility of tracking actives through the skin; the next step should be recording in vivo kinetics. Thus, we conducted a study to evaluate th...

journal_title：Journal of biophotonics

authors： Tfaili S,Josse G,Angiboust JF,Manfait M,Piot O

更新日期：2014-09-01 00:00:00

abstract：:Surface-enhanced Raman scattering (SERS) is highly sensitive and label-free analytical technique based on Raman spectroscopy aided by field-multiplying plasmonic nanostructures. We report the use of SERS measurements of patient urine in conjunction with biostatistical algorithms to assess the treatment response of pro...

journal_title：Journal of biophotonics

authors： Ma Y,Chi J,Zheng Z,Attygalle A,Kim IY,Du H

更新日期：2021-01-01 00:00:00

abstract：:Ionizing radiation (IR) induces DNA damage and low-level laser therapy (LLLT) has been investigated to prevent or repair detrimental outcomes resulting from IR exposure. Few in vitro studies, however, explore the biological mechanisms underlying those LLLT benefits. Thus, in this work, fibroblasts and tumor cells are ...

journal_title：Journal of biophotonics

authors： Ramos Silva C,Cabral FV,de Camargo CF,Núñez SC,Mateus Yoshimura T,de Lima Luna AC,Maria DA,Ribeiro MS

更新日期：2016-12-01 00:00:00

abstract：:The authors have developed a tomographic diffractive microscope that combines microholography with illumination from an angular synthetic aperture. It images specimens relative to their complex index of refraction distribution (index and absorption) and permits imaging of unlabelled specimens, with high lateral resolu...

journal_title：Journal of biophotonics

authors： Simon B,Debailleul M,Beghin A,Tourneur Y,Haeberlé O

更新日期：2010-07-01 00:00:00

abstract：:Lasers/LEDs demonstrate therapeutic effects for a range of biomedical applications. However, a consensus on effective light irradiation parameters and efficient and reliable measurement techniques remain limited. The objective here is to develop, characterise and demonstrate the application of LED arrays in order to p...

journal_title：Journal of biophotonics

authors： Hadis MA,Cooper PR,Milward MR,Gorecki PC,Tarte E,Churm J,Palin WM

更新日期：2017-11-01 00:00:00

abstract：:There has been increasing use of in vitro cell culture models that more realistically replicate the three-dimensional (3D) environment found in vivo. Multicellular tumor spheroids (MTS) using cell lines or patient-derived organoids have become an important in vitro drug development tool, where cells are grown in a 3D ...

journal_title：Journal of biophotonics

authors： Jamieson LE,Harrison DJ,Campbell CJ

更新日期：2019-05-01 00:00:00

abstract：:Highly emissive europium complexes with specific endoplasmic reticulum localization potential includes several advantages such as fast uptake, long resident lifetime, low dosage requirement, low cytotoxicity and highly emissive two-photon induced f-f emission imaging. ...

journal_title：Journal of biophotonics

authors： Law GL,Wong KL,Man CW,Tsao SW,Wong WT

更新日期：2009-12-01 00:00:00

abstract：:Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with metastatic potential. To reduce reoperations due to nonradical excision, there is a need to develop a technique for identification of tumor margins preoperatively. Photoacoustic (PA) imaging is a novel imaging technology that combines the strengths ...

journal_title：Journal of biophotonics

authors： Hult J,Dahlstrand U,Merdasa A,Wickerström K,Chakari R,Persson B,Cinthio M,Erlöv T,Albinsson J,Gesslein B,Sheikh R,Malmsjö M

更新日期：2020-05-01 00:00:00

abstract：:Quantification of the mucosa oxygenation levels during Endoscopic imaging provides useful physiological/diagnostic information. In this work a method for non-contact quantification of the oxygen saturation index during Endoscopic imaging using three discrete spectral-band in the blue, the green, and the red parts of t...

journal_title：Journal of biophotonics

authors： Fawzy Y

更新日期：2009-12-01 00:00:00

abstract：:It is well known that, under exposure to bright light, eggs tend to hatch earlier than control, without any damage to the birds. This report aims to systematically show the effect and establishes a proposal for a possible application to accelerate chicken egg formation, which could be extrapolated or adapted as a grea...

journal_title：Journal of biophotonics

authors： Buzzá HH,Zangirolami AC,Kurachi C,Bagnato VS

更新日期：2018-02-01 00:00:00

abstract：:An experimental study of the influence of the conformational change suffered by molecular beacon (MB) probes-upon the biorecognition of nucleic acid target oligonucleotides over evanescent wave photonic sensors-is reported. To this end, high sensitivity photonic sensors based on silicon photonic bandgap (PBG) structur...

journal_title：Journal of biophotonics

authors： Ruiz-Tórtola Á,Prats-Quílez F,González-Lucas D,Bañuls MJ,Maquieira Á,Wheeler G,Dalmay T,Griol A,Hurtado J,Bohlmann H,Götzen R,García-Rupérez J

更新日期：2018-10-01 00:00:00

abstract：:One of the challenges in transcranial low-level laser therapy (LLLT) is to optimally choose illumination parameters, such as wavelength. However, there is sparse study on the wavelengths comparison especially on human transcranial LLLT. Here, we employed Monte Carlo modeling and visible human phantom to compute the pe...

journal_title：Journal of biophotonics

authors： Wang P,Li T

更新日期：2019-02-01 00:00:00

abstract：:Skin optical clearing has shown tremendous potential in improving various optical imaging performances, but there is some certain blindness in screening out high-efficiency in vivo optical clearing methods. In this work, three optical clearing agents: sucrose (Suc), fructose (Fruc) and PEG-400 (PEG), and two chemical ...

journal_title：Journal of biophotonics

authors： Shi R,Guo L,Zhang C,Feng W,Li P,Ding Z,Zhu D

更新日期：2017-06-01 00:00:00

abstract：:We suggest to use a combination of optical tweezers and single-image quantitative differential interference contrast (DIC) emulated by a spatial light modulator (SLM) to study physiological shape changes in thrombocytes after activation and demonstrate the effectiveness of this system for the given task. A specially d...

journal_title：Journal of biophotonics

authors： Khan S,Jesacher A,Nussbaumer W,Bernet S,Ritsch-Marte M

更新日期：2011-09-01 00:00:00

abstract：:Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. Here, we develop and compare different approaches for developing Raman classification algorithms to diagnose invasive and in situ breast cancer, fibrocystic change and fibroadenoma that can be associ...

journal_title：Journal of biophotonics

authors： Dingari NC,Barman I,Saha A,McGee S,Galindo LH,Liu W,Plecha D,Klein N,Dasari RR,Fitzmaurice M

更新日期：2013-04-01 00:00:00

abstract：:Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization properties (using polarization sensitive OCT). However, these methods are only sui...

journal_title：Journal of biophotonics

authors： Harper DJ,Konegger T,Augustin M,Schützenberger K,Eugui P,Lichtenegger A,Merkle CW,Hitzenberger CK,Glösmann M,Baumann B

更新日期：2019-12-01 00:00:00

abstract：:Nacre is a complex biomaterial made of aragonite-tablet bricks and organic mortar that is considerably resilient against breakage. Nacre has been studied with a wide range of laboratory techniques, leading to understanding key fundamentals and informing the creation of bio-inspired materials. In this article, we prese...

journal_title：Journal of biophotonics

authors： Jones JA,Metzler RA,D'Addario AJ,Burgess C,Regan B,Spano S,Cvarch BA,Galvez EJ

更新日期：2018-10-01 00:00:00

abstract：:Stereotaxic instruments are increasingly used in research animals for the study of disease, but typically require restraints and anesthetic procedures. A stereotaxic head mount that enables imaging of the anterior chamber of the eye in alert and freely mobile mice is presented in this study. The head mount is fitted b...

journal_title：Journal of biophotonics

authors： Paulson B,Lee S,Jue M,Lee K,Lee S,Kim GB,Moon Y,Lee JY,Kim N,Kim JK

更新日期：2020-05-01 00:00:00

abstract：:FTIR microspectroscopy was applied for studying macromolecular changes in human serum samples from patients with healthy livers, and those diagnosed with liver cirrhosis or hepatocellular carcinoma (HCC). Our study demonstrated that the serum samples from HCC and cirrhotic patients could readily be discriminated from ...

journal_title：Journal of biophotonics

authors： Thumanu K,Sangrajrang S,Khuhaprema T,Kalalak A,Tanthanuch W,Pongpiachan S,Heraud P

更新日期：2014-04-01 00:00:00

abstract：:Near-infrared light allows measuring tissue oxygenation. These measurements relay on oxygenation-dependent absorption spectral changes. However, the tissue scattering, which is also spectral dependent, introduces an intrinsic error. Most methods focus on the volume reflectance from a semi-infinite sample. We have prop...

journal_title：Journal of biophotonics

authors： Duadi H,Feder I,Fixler D

更新日期：2018-04-01 00:00:00

abstract：:Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air-puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion ...

journal_title：Journal of biophotonics

authors： Jin Z,Chen S,Dai Y,Bao C,Ye S,Zhou Y,Wang Y,Huang S,Wang Y,Shen M,Zhu D,Lu F

更新日期：2020-08-01 00:00:00

abstract：:Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading ...

journal_title：Journal of biophotonics

authors： Matsuki D,Adewale O,Horie S,Okajima J,Komiya A,Oluwafemi O,Maruyama S,Mori S,Kodama T

更新日期：2017-12-01 00:00:00

abstract：:Methods of nonlinear optics provide a vast arsenal of tools for label-free brain imaging, offering a unique combination of chemical specificity, the ability to detect fine morphological features, and an unprecedentedly high, subdiffraction spatial resolution. While these techniques provide a rapidly growing platform f...

journal_title：Journal of biophotonics

authors： Lanin AA,Pochechuev MS,Chebotarev AS,Kelmanson IV,Belousov VV,Zheltikov AM

更新日期：2019-11-01 00:00:00

abstract：:Conventional histopathology is rapidly shifting towards digital integration. Will microscopes (and pathologists) soon be obsolete? Or are we dealing with just another image modality that leaves the core of tissue diagnosis intact? This article provides an overview of current digital pathology applications and research...

journal_title：Journal of biophotonics

authors： Brachtel E,Yagi Y

更新日期：2012-04-01 00:00:00