听力与言语-语言病理学

行为科学

医学伦理学

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  • Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia.

    abstract:OBJECTIVE:Activin is a growth and differentiation factor of many cell types, and has recently been implicated in inflammatory processes. Clinical data linking activin and its binding protein, follistatin (FS), are lacking. We measured serum levels of activin and FS in patients diagnosed with septicemia. PATIENTS AND M...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480559

    authors: Michel U,Ebert S,Phillips D,Nau R

    更新日期:2003-05-01 00:00:00

  • Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience.

    abstract:UNLABELLED:To improve management of patients with Graves' orbitopathy, a multi-center collaborative approach is necessary in order to have large enough sample sizes for meaningful randomized clinical trials. This is hampered by a lack of consensus on how to investigate the eye condition. The European Group on Graves' O...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/eje.0.1480491

    authors: Prummel MF,Bakker A,Wiersinga WM,Baldeschi L,Mourits MP,Kendall-Taylor P,Perros P,Neoh C,Dickinson AJ,Lazarus JH,Lane CM,Heufelder AE,Kahaly GJ,Pitz S,Orgiazzi J,Hullo A,Pinchera A,Marcocci C,Sartini MS,Rocchi R,N

    更新日期:2003-05-01 00:00:00

  • Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

    abstract:OBJECTIVE:Free fatty acids (FFAs) deplete the intracellular insulin stores of pancreatic beta-cells. It has been suggested that this results from a lipotoxic dysregulation of both insulin secretion and insulin synthesis. In the present study, this hypothesis was tested within a 12-h time-course by directly relating the...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480481

    authors: Bollheimer LC,Kemptner DM,Kagerbauer SM,Kestler TM,Wrede CE,Buettner R

    更新日期:2003-04-01 00:00:00

  • Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas.

    abstract:OBJECTIVE:A significant decrease in vitamin D receptor (VDR) and calcium-sensing receptor (CaSR) protein expression has been demonstrated recently in parathyroid (PT) adenomas. In this study, we investigated the relationships between the proliferative activity of parathyroid glands (PTGs) and the expression of VDR as w...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480403

    authors: Yano S,Sugimoto T,Tsukamoto T,Chihara K,Kobayashi A,Kitazawa S,Maeda S,Kitazawa R

    更新日期:2003-04-01 00:00:00

  • The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area.

    abstract:BACKGROUND:The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter. OBJECTIVE:The aim of the present study was to define the prevalence of anti-thyroid peroxidase ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480301

    authors: Kabelitz M,Liesenkötter KP,Stach B,Willgerodt H,Stäblein W,Singendonk W,Jäger-Roman E,Litzenbörger H,Ehnert B,Grüters A

    更新日期:2003-03-01 00:00:00

  • Anthropometric, haemodynamic, humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery.

    abstract:OBJECTIVE:To compare clinical and humoral parameters before and after surgery in patients with incidental adrenocortical adenomas. DESIGN:Six patients with subclinical Cushing's syndrome and nine with non-functioning adenomas were investigated before and 12 Months after removal of the mass. METHODS:Anthropometric (bo...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480213

    authors: Bernini G,Moretti A,Iacconi P,Miccoli P,Nami R,Lucani B,Salvetti A

    更新日期:2003-02-01 00:00:00

  • Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.

    abstract:OBJECTIVE AND DESIGN:Based on our clinical experience with combined gene therapy of glioblastoma, we developed a retroviral vector expressing two therapeutic genes (i.e. thymidine kinase of herpes simplex virus, HSV-TK, and interleukin-2, IL-2) and evaluated its efficiency in vitro and in vivo. METHODS:Expression of t...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480073

    authors: Barzon L,Bonaguro R,Castagliuolo I,Chilosi M,Franchin E,Del Vecchio C,Giaretta I,Boscaro M,Palù G

    更新日期:2003-01-01 00:00:00

  • Autoimmune thyroid disease: propagation and progression.

    abstract::Autoimmune thyroid disease is the archetype for organ-specific autoimmune disorders. Progress in treating these disorders lies in improvements of our understanding of the predisposing factors responsible, the mechanisms responsible for progression of disease, and the interaction between thyroid antigens and the immune...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1480001

    authors: Weetman AP

    更新日期:2003-01-01 00:00:00

  • Effects of dehydration on endocrine regulation of the electrolyte and fluid balance and atrial natriuretic peptide-binding sites in perinatally malnourished adult male rats.

    abstract:OBJECTIVE:The first aim of this work was to investigate, under basal conditions in adult male rats, the long-term consequences of perinatal maternal food restriction on the plasma concentrations of vasopressin (VP), aldosterone and atrial natriuretic peptide (ANP) and on plasma renin activity (PRA). Furthermore, under ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470835

    authors: Sebaai N,Lesage J,Alaoui A,Dupouy JP,Deloof S

    更新日期:2002-12-01 00:00:00

  • Isolated GH deficiency (IGHD) type II: imaging of the pituitary gland by magnetic resonance reveals characteristic differences in comparison with severe IGHD of unknown origin.

    abstract:OBJECTIVE:To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II). DESIGN:The pituitary gland morphology in magnetic resonance imaging (MRI) of children with IGHD type II was analyzed and compared with the findings in a group ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470755

    authors: Binder G,Nagel BH,Ranke MB,Mullis PE

    更新日期:2002-12-01 00:00:00

  • Exclusive underexpression of vitamin D receptor exon 1f transcripts in tumors of primary hyperparathyroidism.

    abstract:OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470671

    authors: Correa P,Akerstrom G,Westin G

    更新日期:2002-11-01 00:00:00

  • Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene.

    abstract:OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470591

    authors: Salvatori R,Fan X,Veldhuis JD,Couch R

    更新日期:2002-11-01 00:00:00

  • Molecular defects of the CYP21 gene in Spanish girls with isolated precocious pubarche.

    abstract:OBJECTIVE:To determine the frequency of mutant alleles in the CYP21 gene in Spanish girls presenting with precocious pubarche (PP) and to assess the relationships between genotype and endocrine-metabolic variables. DESIGN:Fifty-three unrelated girls with a history of PP (14 prepubertal, 8 pubertal and 31 postmenarchea...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470485

    authors: Potau N,Riqué S,Eduardo I,Marcos V,Ibañez L

    更新日期:2002-10-01 00:00:00

  • Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis.

    abstract:OBJECTIVE:In malnutrition both the GH-IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. DESIGN AND METHODS:Peripubertal (30 days of age) f...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470417

    authors: Goya L,García-Segura LM,Ramos S,Pascual-Leone AM,Argente J,Martín MA,Chowen JA

    更新日期:2002-09-01 00:00:00

  • Reduced microvascular perfusion and reactivity in adult GH deficient patients is restored by GH replacement.

    abstract:BACKGROUND:An increased cardiovascular risk and mortality in hypopituitary patients receiving conventional hormonal treatment without GH replacement have been shown in several studies. Various atherogenic risk factors including endothelial dysfunction - an early event in the atherogenesis - are more expressed in adults...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470333

    authors: Hána V,Prázný M,Marek J,Skrha J,Justová V

    更新日期:2002-09-01 00:00:00

  • Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas.

    abstract:OBJECTIVE:Local 5'-deiodination of l-thyroxine (T(4)) to active thyroid hormone 3,3',5-tri-iodothyronine (T(3)) catalyzed by the two 5'-deiodinase enzymes (D1 and D2) regulates various T(3)-dependent functions in the anterior pituitary and has been well studied in rodents. Only limited information about deiodinase expr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470263

    authors: Baur A,Buchfelder M,Köhrle J

    更新日期:2002-08-01 00:00:00

  • Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly.

    abstract:INTRODUCTION:In an animal model of acromegaly (PEPCK-hGH transgenic mice), low systemic levels of ghrelin have been observed compared with normal mice. We hypothesized that systemic circulating ghrelin levels are also decreased in humans with active acromegaly and that the contribution of central ghrelin production to ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470195

    authors: van der Toorn FM,Janssen JA,de Herder WW,Broglio F,Ghigo E,van der Lely AJ

    更新日期:2002-08-01 00:00:00

  • Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.

    abstract:OBJECTIVE:GH causes insulin resistance, impairs glycemic control and increases the risk of vascular diabetic complications. Sulphonylureas stimulate GH secretion and this study was undertaken to investigate the possible stimulatory effect of repaglinide and nateglinide, two novel oral glucose regulators, on critical st...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470133

    authors: Gromada J,Bokvist K,Høy M,Olsen HL,Lindström P,Hansen BS,Gotfredsen CF,Rorsman P,Thomsen MK

    更新日期:2002-07-01 00:00:00

  • Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years.

    abstract:OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1530/eje.0.1470059

    authors: le Roux CW,Jenkins PJ,Chew SL,Camacho-Hübner C,Grossman AB,Besser GM,Monson JP

    更新日期:2002-07-01 00:00:00

  • Reduction of insulin secretion in the insulinoma cell line INS-1 by overexpression of a Ca(v)2.3 (alpha1E) calcium channel antisense cassette.

    abstract:OBJECTIVE:Multiple types of voltage-activated Ca(2+) channels (T, L, N, P, Q and R type) coordinate a variety of Ca(2+)-dependent processes in neurons and neuroendocrine cells. In insulinoma cell lines as well as in endocrine tissues, the non-L-type alpha1E (Ca(v)2.3) subunit is expressed as the tissue-specific splice ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460881

    authors: Pereverzev A,Vajna R,Pfitzer G,Hescheler J,Klöckner U,Schneider T

    更新日期:2002-06-01 00:00:00

  • Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH.

    abstract:OBJECTIVE:The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells. The aim of the study was to assess Sertoli cell function in subjects with AZFc deletions. DESIGN:Case-cont...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460801

    authors: Foresta C,Bettella A,Moro E,Rossato M,Merico M,Garolla A,Ferlin A

    更新日期:2002-06-01 00:00:00

  • Effect of chronic thyroxine treatment on IGF-I, IGF-II and IGF-binding protein expression in mammary gland and liver during pregnancy and early lactation in rats.

    abstract:OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460729

    authors: Rosato R,Lindenbergh-Kortleve D,Neck Jv,Drop S,Jahn G

    更新日期:2002-05-01 00:00:00

  • Clinical and molecular analysis of three families with autosomal dominant neurohypophyseal diabetes insipidus associated with a novel and recurrent mutations in the vasopressin-neurophysin II gene.

    abstract:OBJECTIVE:To test further the hypothesis that autosomal dominant neurohypophyseal diabetes insipidus (adFNDI) is caused by heterozygous mutations in the vasopressin-neurophysin II (AVP-NPII) gene that exert a dominant negative effect by producing a precursor that misfolds, accumulates and eventually destroys the neuros...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460649

    authors: Rutishauser J,Kopp P,Gaskill MB,Kotlar TJ,Robertson GL

    更新日期:2002-05-01 00:00:00

  • Binding of heparin to human thyroglobulin (Tg) involves multiple binding sites including a region corresponding to a binding site of rat Tg.

    abstract:OBJECTIVE:Binding of thyroglobulin (Tg) to heparin allows efficient Tg interaction with its endocytic receptor, megalin. Rat Tg (rTg) binds to heparin using an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues which is, however, not entirely conserved in human Tg (h...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460591

    authors: Lisi S,Pinchera A,McCluskey RT,Chiovato L,Marinò M

    更新日期:2002-04-01 00:00:00

  • Mutational analysis of the autoimmune regulator (AIRE) gene in sporadic autoimmune Addison's disease can reveal patients with unidentified autoimmune polyendocrine syndrome type I.

    abstract:OBJECTIVE:To investigate whether patients with Addison's disease and polyendocrine syndromes have undiagnosed autoimmune polyendocrine syndrome type I (APS I). MATERIALS AND METHODS:Forty patients with clinical manifestations resembling APS I and with autoantibodies typical of this condition were screened for Norwegia...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460519

    authors: Bøe AS,Knappskog PM,Myhre AG,Sørheim JI,Husebye ES

    更新日期:2002-04-01 00:00:00

  • Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes.

    abstract:OBJECTIVE:Glucocorticoid excess leads to insulin resistance. This study explores the effects of glucocorticoids on the glucose transport system and insulin signalling in rat adipocytes. The interaction between glucocorticoids and high levels of insulin and glucose is also addressed. DESIGN AND METHODS:Isolated rat adi...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460419

    authors: Burén J,Liu HX,Jensen J,Eriksson JW

    更新日期:2002-03-01 00:00:00

  • The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.

    abstract:OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1530/eje.0.1460339

    authors: Wickman S,Saukkonen T,Dunkel L

    更新日期:2002-03-01 00:00:00

  • Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas.

    abstract:OBJECTIVE:To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs). METHODS:Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH). RESULTS:The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460209

    authors: Garcia JL,Tardio JC,Gutierrez NC,Gonzalez MB,Polo JR,Hernandez JM,Menarguez J

    更新日期:2002-02-01 00:00:00

  • Growth hormone deficiency and replacement in hypopituitary patients previously treated for acromegaly or Cushing's disease.

    abstract:OBJECTIVE:To compare baseline characteristics in adult patients with growth hormone (GH) deficiency (GHD) who had previously been treated for Cushing's disease or acromegaly with data from patients with GHD of other aetiologies. To study the effects of GH therapy in those patients who had completed at least 6 months of...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460067

    authors: Feldt-Rasmussen U,Abs R,Bengtsson BA,Bennmarker H,Bramnert M,Hernberg-Ståhl E,Monson JP,Westberg B,Wilton P,Wüster C,KIMS International Study Board of KIMS Study Group.

    更新日期:2002-01-01 00:00:00

  • Biology of the gonadotropin-releasing hormone system in gynecological cancers.

    abstract::The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1460001

    authors: Gründker C,Günthert AR,Westphalen S,Emons G

    更新日期:2002-01-01 00:00:00

  • Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years.

    abstract:OBJECTIVE:To assess the effect of age on clinical, endocrine and sonographic features associated with polycystic ovary syndrome (PCOS) in normogonadotrophic anovulatory infertile women of reproductive years. DESIGN:Cross-sectional study. METHODS:Four hundred and seventy-two oligo-amenorrhoeic infertile patients, pres...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1450749

    authors: Bili H,Laven J,Imani B,Eijkemans MJ,Fauser BC

    更新日期:2001-12-01 00:00:00

  • Female gonadal development in XX patients with distal 9p monosomy.

    abstract:OBJECTIVE:A sex determining gene(s) has been mapped to a approximately 700 kb region distal to the exons of DMRT1 on 9p. The aim of this study was to examine gonadal developmental status in XX patients hemizygous for the 9p sex determining region. DESIGN:Clinical and molecular studies were performed in an 8-year-old g...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1530/eje.0.1450613

    authors: Ogata T,Muroya K,Ohashi H,Mochizuki H,Hasegawa T,Kaji M

    更新日期:2001-11-01 00:00:00

  • In vitro and in vivo herpetic vector-mediated gene transfer in the pituitary gland: impact on hormone secretion.

    abstract:OBJECTIVE:Herpes simplex virus type 1 (HSV-1)-derived vectors are known to be effective tools to deliver transgenes into normal and neoplastic anterior pituitary (AP) cells in vitro. Our objective was to assess the in vitro and in vivo effects of tsK/beta-gal, a temperature-sensitive HSV-1-derived vector harbouring the...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1450497

    authors: Bolognani F,Albariño C,Romanowski V,Carri NG,Goya RG

    更新日期:2001-10-01 00:00:00

  • Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism.

    abstract:BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/eje.0.1450429

    authors: dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

    更新日期:2001-10-01 00:00:00

  • Leptin response to endogenous acute stress is independent of pituitary function.

    abstract::There are close interactions between the adipocyte-derived hormone, leptin, and the anterior pituitary, especially the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the relationship between the sympathetic adrenergic system and serum leptin levels, dependent on the function of anterior pituitary hormone a...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1450295

    authors: Schafroth U,Godang K,Ueland T,Bollerslev J

    更新日期:2001-09-01 00:00:00

  • Familial isolated primary hyperparathyroidism--a multiple endocrine neoplasia type 1 variant?

    abstract:OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is defined as hereditary primary hyperparathyroidism without the association of other diseases or tumors. Linkage analyses suggest that different genotypes can lead to the same phenotype of primary hyperparathyroidism. Hereditary syndromes associated with p...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1450155

    authors: Miedlich S,Lohmann T,Schneyer U,Lamesch P,Paschke R

    更新日期:2001-08-01 00:00:00

  • A luteinizing hormone-, alpha-subunit- and prolactin-secreting pituitary adenoma responsive to somatostatin analogs: in vivo and in vitro studies.

    abstract:OBJECTIVE:Evaluation of the efficiency of somatostatin analogues in the treatment of a mixed luteinizing hormone (LH)-, alpha-subunit-, prolactin (PRL)-secreting pituitary adenoma. DESIGN:A 30-year-old woman, with amenorrhaea-galactorrhaea, presented with a pituitary macroadenoma. The endocrine evaluation showed high ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1450035

    authors: Saveanu A,Morange-Ramos I,Gunz G,Dufour H,Enjalbert A,Jaquet P

    更新日期:2001-07-01 00:00:00

  • Effects of leptin on secretion of LH and FSH from primary cultured female rat pituitary cells.

    abstract:BACKGROUND:Leptin, which is the product of the obese gene, is believed to play important roles in pubertal development and reproductive function in females. In a study using adult male rats, it was found that leptin stimulated secretion of gonadotropin from the pituitary in a dose-related manner. However, there has bee...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1440653

    authors: Ogura K,Irahara M,Kiyokawa M,Tezuka M,Matsuzaki T,Yasui T,Kamada M,Aono T

    更新日期:2001-06-01 00:00:00

  • Radiotherapy for non-functioning pituitary adenomas.

    abstract::The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitar...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1440569

    authors: Boelaert K,Gittoes NJ

    更新日期:2001-06-01 00:00:00

  • The decrease in hepatic IGF-I gene expression in arthritic rats is not associated with modifications in hepatic GH receptor mRNA.

    abstract:OBJECTIVE:Adjuvant-induced arthritis induces a catabolic response, and a decrease in circulating IGF-I. Hypermetabolism and GH insensitivity have been described in acute inflammation. The aim of this study was to analyze whether impaired IGF-I secretion in arthritic rats can be attributed to hepatic GH resistance. DES...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1440529

    authors: Lopez-Calderon A,Ibáñez de Caceres I,Soto L,Priego T,Martin AI,Villanua MA

    更新日期:2001-05-01 00:00:00

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