Abstract:
BACKGROUND:Leptin, which is the product of the obese gene, is believed to play important roles in pubertal development and reproductive function in females. In a study using adult male rats, it was found that leptin stimulated secretion of gonadotropin from the pituitary in a dose-related manner. However, there has been no such study in female rats. OBJECTIVE:To investigate the effects of leptin on the production of LH and FSH from the pituitary in female rats, using primary cultured pituitary cells. METHODS:In this study, we determined body weight, serum leptin concentration and serum estradiol (E(2)) concentration in female Wistar rats at 3, 5, 6, 7, 9 and 11 weeks of age, and cultured pituitary cells from 6-week-old female Wistar rats with leptin (0--10(-7) mol/l) and GnRH (0 or 10(-8) mol/l). Then basal and GnRH-stimulated extra- and intracellular LH and FSH were assayed by RIA. RESULTS:Serum leptin concentration increased with increases in body weight and E(2) concentration. The pubertal serum leptin concentration was about 10(-10) mol/l. At a lower or moderate concentration, leptin produced dose-related increases in both basal and GnRH-stimulated extra- and intracellular LH and FSH in pituitary cells. At a concentration of 10 mol/l, leptin significantly (P<0.05) stimulated both basal and GnRH-stimulated extra- and intracellular LH and FSH. However, at greater concentrations, these effects diminished. CONCLUSIONS:These results indicated that leptin induced pituitary cells to produce and secrete both LH and FSH, with or without GnRH. The concentration of leptin that induced the greatest production of gonadotropins by pituitary cells was 10(-10) mol/l, which was the same as the physiological pubertal concentration. Leptin may be involved in the onset of puberty. It is also conceivable that leptin may be a cause of ovulatory failure, not only in weight loss but also in weight gain.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Ogura K,Irahara M,Kiyokawa M,Tezuka M,Matsuzaki T,Yasui T,Kamada M,Aono Tdoi
10.1530/eje.0.1440653subject
Has Abstractpub_date
2001-06-01 00:00:00pages
653-8issue
6eissn
0804-4643issn
1479-683Xpii
1440653journal_volume
144pub_type
杂志文章abstract:CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...
journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVE:Makorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic-pituitary-gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys before and during puberty and assessed the effect of inhibition of estrogen ...
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-05-10 00:00:00
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更新日期:1996-04-01 00:00:00
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更新日期:2011-10-01 00:00:00
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更新日期:2013-09-12 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.1.01994
更新日期:2005-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00