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Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring.

Abstract：

INTRODUCTION:The fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy. The effects of mild iodine deficiency and subclinical hypothyroidism are poorly known. The present study assesses the association between thyroid hormones (TH)s and urinary iodine concentration (UIC) in healthy pregnant women and the birth weight of their children. METHODS:About 657 pregnant women were recruited in Sabadell and followed until delivery. The association between THs during the first trimester, UIC during the first and third trimesters, and birth weight was studied in 557, 251, and 528 mother-newborn pairs respectively, using linear and logistic regression models adjusted for potential confounders. Only 239 women had all the data available (thyroid function and UIC at the first and third trimesters). Six percent of newborns were classified as small for gestational age (SGA). RESULTS:The median UIC was 95 and 104 microg/l during the first and third trimesters respectively. Women with the third trimester UICs between 100 and 149 microg/l had lower risk of having an SGA newborn than women with UICs below 50 microg/l (adjusted OR (95%CI): 0.15 (0.03-0.76). There was no significant reduction in SGA among mothers with higher UICs. Lower free thyroxine and higher TSH levels during the first trimester were not associated with birth weight or SGA. Nevertheless, the analyses were repeated including only those women with all the data available, and high TSH levels became statistically significantly associated with lower birth weight and higher risk of SGA. CONCLUSIONS:The present study suggests that iodine status during pregnancy may be related to prenatal growth in healthy women.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Alvarez-Pedrerol M,Guxens M,Mendez M,Canet Y,Martorell R,Espada M,Plana E,Rebagliato M,Sunyer J

doi

10.1530/EJE-08-0716

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

423-9

issue

3

eissn

0804-4643

issn

1479-683X

pii

EJE-08-0716

journal_volume

160

pub_type

杂志文章

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