Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiology.

abstract：BACKGROUND:Epidemiological studies suggest that hypopituitary patients have an increased risk for cardiovascular mortality. The dyslipidaemia associated with this condition is often characterised by an increase in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol (LDL-C) and may contribute to these f...

journal_title：European journal of endocrinology

authors： Christ ER,Cummings MH,Stolinski M,Jackson N,Lumb PJ,Wierzbicki AS,Sönksen PH,Russell-Jones DL,Umpleby AM

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. DESIGN:The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease. METHODS:TSH, free th...

journal_title：European journal of endocrinology

authors： van de Ven AC,Netea-Maier RT,de Vegt F,Ross HA,Sweep FC,Kiemeney LA,Smit JW,Hermus AR,den Heijer M

更新日期：2014-08-01 00:00:00

abstract：:The rat prostate, a classical androgen-target tissue, contains both known isozymes of steroid 5alpha-reductase. i.e. type I and type II. So far, the role of the type I isozyme has been proposed as catabolic. The abundant expression of type I 5alpha-reductase in an androgen-target tissue is therefore puzzling. Assessme...

journal_title：European journal of endocrinology

authors： Span PN,Sweep CG,Benraad TJ,Smals A

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Phytosterolaemia (sitosterolaemia) is a rare autosomal recessive condition caused by mutations on the ABCG5 and ABCG8 gut transporter proteins. This leads to accumulation of plant-derived cholesterol-like molecules in blood and tissues. CASE:We describe a family of Bangladesh origin, where three siblings (t...

journal_title：European journal of endocrinology

authors： Mushtaq T,Wales JK,Wright NP

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:The type 2 deiodinase (D2) is a key enzyme for intracellular triiodothyronine (T(3)) generation. A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. Our aim was to evaluate whether the D2 Thr92Ala polymorphi...

journal_title：European journal of endocrinology

authors： Dora JM,Machado WE,Rheinheimer J,Crispim D,Maia AL

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were t...

journal_title：European journal of endocrinology

authors： Valassi E,Crespo I,Keevil BG,Aulinas A,Urgell E,Santos A,Trainer PJ,Webb SM

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...

journal_title：European journal of endocrinology

authors： Narumi S,Araki S,Hori N,Muroya K,Yamamoto Y,Asakura Y,Adachi M,Hasegawa T

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality. DESIGN:Cross-sectional study. METHODS:A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this stud...

journal_title：European journal of endocrinology

authors： Pickering L,Jennum P,Gammeltoft S,Poulsgaard L,Feldt-Rasmussen U,Klose M

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (P...

journal_title：European journal of endocrinology

authors： Cuestas E,Gaido MI,Capra RH

更新日期：2015-04-01 00:00:00

abstract：:Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

journal_title：European journal of endocrinology

authors： Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

更新日期：2020-12-01 00:00:00

abstract：:Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40  mm or more, signi...

journal_title：European journal of endocrinology

authors： Maiter D,Delgrange E

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 1...

journal_title：European journal of endocrinology

authors： Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：:Objective Chronic hypoparathyroidism and its treatment may lead to symptoms and complications affecting quality of life. We determined complications in chronic hypoparathyroid patients. Design Retrospective cross-sectional study of patients with chronic hypoparathyroidism treated with active vitamin D supplements in a...

journal_title：European journal of endocrinology

authors： David K,Moyson C,Vanderschueren D,Decallonne B

更新日期：2019-01-01 00:00:00

abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

journal_title：European journal of endocrinology

authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:We studied the intervention of nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) in mediating responses to acetylcholine in thyroid arteries from euthyroid and methimazole-treated (MT) patients. DESIGN AND METHODS:Branches of the superior thyroid artery were obtained from ...

journal_title：European journal of endocrinology

authors： Ortega J,Vila JM,Mauricio MD,Segarra G,Medina P,Martínez-León JB,Lluch S

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is defined as hereditary primary hyperparathyroidism without the association of other diseases or tumors. Linkage analyses suggest that different genotypes can lead to the same phenotype of primary hyperparathyroidism. Hereditary syndromes associated with p...

journal_title：European journal of endocrinology

authors： Miedlich S,Lohmann T,Schneyer U,Lamesch P,Paschke R

更新日期：2001-08-01 00:00:00

abstract：CONTEXT:CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancr...

journal_title：European journal of endocrinology

authors： Pasquali D,Circelli L,Faggiano A,Pancione M,Renzullo A,Elisei R,Romei C,Accardo G,Coppola VR,De Palma M,Ferolla P,Grimaldi F,Colao A,Colantuoni V

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:To improve management of patients with Graves' orbitopathy, a multi-center collaborative approach is necessary in order to have large enough sample sizes for meaningful randomized clinical trials. This is hampered by a lack of consensus on how to investigate the eye condition. The European Group on Graves' O...

journal_title：European journal of endocrinology

authors： Prummel MF,Bakker A,Wiersinga WM,Baldeschi L,Mourits MP,Kendall-Taylor P,Perros P,Neoh C,Dickinson AJ,Lazarus JH,Lane CM,Heufelder AE,Kahaly GJ,Pitz S,Orgiazzi J,Hullo A,Pinchera A,Marcocci C,Sartini MS,Rocchi R,N

更新日期：2003-05-01 00:00:00

abstract：:Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitut...

journal_title：European journal of endocrinology

authors： Albuquerque EVA,Scalco RC,Jorge AAL

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

journal_title：European journal of endocrinology

authors： Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE:The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematolog...

journal_title：European journal of endocrinology

authors： Vivanco M,Dalle JH,Alberti C,Lescoeur B,Yakouben K,Carel JC,Baruchel A,Léger J

更新日期：2012-08-01 00:00:00

abstract：:We report on a 15-year-old girl who had presented with acute onset central diabetes insipidus at the age of 8 years; this was followed by growth failure due to acquired growth hormone deficiency. Initial magnetic resonance imaging showed a uniformly enlarged pituitary stalk and absence of posterior pituitary hyperinte...

journal_title：European journal of endocrinology

authors： Maghnie M,Genovese E,Sommaruga MG,Aricò M,Locatelli D,Arbustini E,Pezzotta S,Severi F

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To determine if human growth hormone (hGH) replacement therapy alters pharmacokinetics of hydrocortisone (CS) substitution in hypopituitary adults. DESIGN:To this aim, we analysed serum and salivary CS profiles 270 min after oral CS administration at baseline and 6 and 12 months after initiation of hGH repla...

journal_title：European journal of endocrinology

authors： Tschöp M,Lahner H,Feldmeier H,Grasberger H,Morrison KM,Janssen OE,Attanasio AF,Strasburger CJ

更新日期：2000-12-01 00:00:00

abstract：:To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

journal_title：European journal of endocrinology

authors： Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown befo...

journal_title：European journal of endocrinology

authors： Tabur S,Torun AN,Sabuncu T,Turan MN,Celik H,Ocak AR,Aksoy N

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Amine precursor uptake and decarboxylation is a classical feature of gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Production of catecholamines was studied in GEP NET and non-NET patients. DESIGN:A cross-sectional study was undertaken. METHODS:We studied catecholamine and metabolite secretion in...

journal_title：European journal of endocrinology

authors： Ciofu A,Baudin E,Chanson P,Cailleux AF,Comoy E,Sabourin JC,Ducreux M,Schaison G,Schlumberger M

更新日期：1999-05-01 00:00:00

abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...

journal_title：European journal of endocrinology

authors： Kubota T,Taguchi M,Kobayashi K,Masuda M,Aso T

更新日期：1997-08-01 00:00:00

abstract：:The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...

journal_title：European journal of endocrinology

authors： Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

更新日期：2001-04-01 00:00:00