Abstract:
:The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cortisol was maintained in elderly subjects, even if with a reduced amplitude of the 24 h fluctuations and a trend to an increase of the serum levels in the evening and at night-time, in comparison with young controls. Furthermore, an age-related impairment of HPA sensitivity to steroid feedback was present in elderly people. The occurrence of senile dementia amplified the changes already present in physiological aging. While the cortisol secretion was generally well maintained in aging, the adrenal production of dehydroepiandrosterone and of its sulfate (DHEAS) exhibited an age-related decline. Therefore, the cortisol/DHEAS molar ratio was significantly higher in elderly subjects and even more in demented ones, than in young controls. Due to the opposite effects of cortisol and DHEAS on the brain and particularly on the hippocampal region, the imbalance between glucocorticoids and androgens occurring in physiological and even more in pathological aging, may have adverse effects on the function of this region, whose key role in learning and memory is well known.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri Fdoi
10.1530/eje.0.1440319subject
Has Abstractpub_date
2001-04-01 00:00:00pages
319-29issue
4eissn
0804-4643issn
1479-683Xpii
1440319journal_volume
144pub_type
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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abstract::There are close interactions between the adipocyte-derived hormone, leptin, and the anterior pituitary, especially the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the relationship between the sympathetic adrenergic system and serum leptin levels, dependent on the function of anterior pituitary hormone a...
journal_title:European journal of endocrinology
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abstract:Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...
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pub_type: 杂志文章,评审
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abstract::Objective Chronic hypoparathyroidism and its treatment may lead to symptoms and complications affecting quality of life. We determined complications in chronic hypoparathyroid patients. Design Retrospective cross-sectional study of patients with chronic hypoparathyroidism treated with active vitamin D supplements in a...
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pub_type: 共识发展会议,杂志文章,评审
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更新日期:2014-08-01 00:00:00
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更新日期:2008-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1450749
更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
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更新日期:2016-02-01 00:00:00
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更新日期:2012-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2013-11-22 00:00:00
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更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00