Abstract：
OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2-159 microg/l; IGF-I, 349-1111 microg/l) were investigated by intraoperative high-field MRI. If intraoperative imaging depicted an accessible tumor remnant, resection was continued. RESULTS:In five patients intraoperative MRI led to further tumor removal, two of these met the consensus criteria for endocrine remission after 3 months. In two patients basal GH and oral glucose tolerance test (OGTT) were <2 microg/l, only IGF-I was slightly elevated, and in one patient GH was <5 microg/l and OGTT was 2 microg/l, with elevated IGF-I. Final intraoperative MRI showed no tumor remnants in 14 patients; eight of them met the consensus criteria for remission of acromegaly. In the patients with MRI showing incomplete removal (four suspect findings and five patients with intended partial removal) none was normalized. CONCLUSION:With regard to the patients with a tumor configuration in whom complete tumor removal was considered (n = 18), intraoperative MRI increased the rate of endocrine normalization from 33 to 44% applying the consensus criteria, and improved endocrine outcome to 'nearly normalization' in another 17%. With regard to preoperative GH levels and tumor size, intraoperative MRI can help to achieve endocrine remission in patients who are normally considered not to be curable. However, taking GH as the tumor marker, even intraoperative high-field MRI was not able to detect tumor remnants in every case.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky Cdoi
10.1530/eje.1.01970subject
Has Abstractpub_date
2005-08-01 00:00:00pages
239-48issue
2eissn
0804-4643issn
1479-683Xpii
153/2/239journal_volume
153pub_type
临床试验,杂志文章abstract：OBJECTIVE:To characterise distinctive clinical features of giant prolactinomas in women. DESIGN:A multicentre, retrospective case series and literature review. METHODS:We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and identified 19 similar case...
journal_title：European journal of endocrinology
pub_type： 杂志文章,多中心研究,评审
doi：10.1530/EJE-13-0503
更新日期：2013-11-22 00:00:00
abstract：:Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-09-0118
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abstract：:none. ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-20-1426
更新日期：2021-01-01 00:00:00
abstract：:We have identified and characterized insulin-like growth factor I (IGF-I) and IGF-II/mannose-6-phosphate (IGF-II/M6P) receptors in bovine adrenal cells. Iodine-125-labeled IGF-I ([125I]IGF-I) binding was characteristic of the IGF-I receptor, and binding kinetics as well as receptor densities were similar in cortical a...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1300265
更新日期：1994-03-01 00:00:00
abstract：:In addition to the classical hormones, the production of numerous polypeptide growth factors, cytokines, vasogenic substances and neuropeptides by pituitary cells has been demonstrated. Expression of the corresponding receptors on pituitary cells enables these factors to influence growth and function of the pituitary ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.1350515
更新日期：1996-11-01 00:00:00
abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1300151
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:To estimate morbidity in Denmark in all patients with GH deficiency (GHD). DESIGN:Morbidity was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in the GHD patients were studied and additional morbidity noted. Diagnoses and dates of admissions were identified in the Nati...
journal_title：European journal of endocrinology
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doi：10.1530/EJE-07-0523
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abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1490343
更新日期：2003-10-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-14-0077
更新日期：2014-04-10 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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abstract：:In recent years, 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-15-0066
更新日期：2015-09-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1300065
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:Vitamin D insufficiency is common in primary hyperparathyroidism (pHPT). Patients with pHPT frequently have a reduced health-related quality of life (HRQoL). Our objectives were to evaluate whether HRQoL in pHPT is associated with vitamin D insufficiency and whether vitamin D supplementation after parathyroid...
journal_title：European journal of endocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1530/EJE-14-0757
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:The uncoupling protein 2 (UCP2) uncouples respiration from the oxidative phosphorylation in most cell types, predominantly in white fat and skeletal muscle. Since a decreased basal metabolic rate (BMR) would increase the susceptibility to weight gain, genetic alterations in the UCP2 gene could contribute to t...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1390217
更新日期：1998-08-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.151u003
更新日期：2004-11-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1350184
更新日期：1996-08-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0794
更新日期：2009-04-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0014
更新日期：2011-07-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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更新日期：2016-04-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0245
更新日期：2009-09-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2014-10-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460209
更新日期：2002-02-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-07-0098
更新日期：2007-07-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460649
更新日期：2002-05-01 00:00:00
abstract：:Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1340073
更新日期：1996-01-01 00:00:00
abstract：:Fifty-five patients with adult-onset GH deficiency (mean age, 49 years) were enrolled in a placebo-controlled, crossover study to investigate the effects of GH therapy on exercise capacity, body composition, and quality of life (QOL). GH and placebo were administered for 9 months each, separated by a 4-month washout p...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1530/eje.1.01971
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Phytosterolaemia (sitosterolaemia) is a rare autosomal recessive condition caused by mutations on the ABCG5 and ABCG8 gut transporter proteins. This leads to accumulation of plant-derived cholesterol-like molecules in blood and tissues. CASE:We describe a family of Bangladesh origin, where three siblings (t...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0222
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:In Cushing's disease (CD), GH responsiveness to several stimuli, including ghrelin, GHRP-6, and GHRH, is blunted. Recovery of GH secretion after remission of hypercortisolism after transsphenoidal surgery, radiotherapy, or adrenalectomy is controversial. There are no studies evaluating the effect of primary c...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0459
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To evaluate which tests are performed to diagnose hypercortisolism in patients included in the European Registry on Cushing's syndrome (ERCUSYN), and to examine if their use differs from the current guidelines. PATIENTS AND METHODS:We analyzed data on the diagnostic tests performed in 1341 patients with Cush...
journal_title：European journal of endocrinology
pub_type： 杂志文章,多中心研究
doi：10.1530/EJE-16-0967
更新日期：2017-05-01 00:00:00
