Association study of AMP-activated protein kinase subunit genes in polycystic ovary syndrome.

abstract：:Here we describe the case of a 41-year-old woman with a history of Cushing disease who had previously undergone unsuccessful neurosurgery, followed by stereotactic radiosurgery. More than 4 years after this treatment, she presented severe visual impairment, which started in the left eye and was documented by neuro-oph...

journal_title：European journal of endocrinology

authors： Boschetti M,De Lucchi M,Giusti M,Spena C,Corallo G,Goglia U,Ceresola E,Resmini E,Vera L,Minuto F,Ferone D

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare physical activity and biochemical markers with bone mineral acquisition in rhythmic gymnasts and ballet dancers. METHODS:Weight, height, body mass index, nutritional intake, bone age and menstrual histories were analyzed in nine rhythmic gymnasts, twelve ballet dancers and fourteen con...

journal_title：European journal of endocrinology

authors： Muñoz MT,de la Piedra C,Barrios V,Garrido G,Argente J

更新日期：2004-10-01 00:00:00

abstract：:Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

journal_title：European journal of endocrinology

authors： Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Mortality in acromegaly strictly depends on optimal control of GH and IGF1 levels. Modern medical therapy with somatostatin analogs (SSAs) and GH receptor antagonists (GHRAs) is not available in many countries due to funding restrictions. This retrospective, comparative, cohort study investigated the impact ...

journal_title：European journal of endocrinology

authors： Colao A,Vandeva S,Pivonello R,Grasso LF,Nachev E,Auriemma RS,Kalinov K,Zacharieva S

更新日期：2014-08-01 00:00:00

abstract：AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

journal_title：European journal of endocrinology

authors： Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...

journal_title：European journal of endocrinology

authors： Maksud FA,Alves JS,Diniz MT,Barbosa AJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, ...

journal_title：European journal of endocrinology

authors： Zevenbergen C,Korevaar TI,Schuette A,Peeters RP,Medici M,Visser TJ,Schomburg L,Visser WE

更新日期：2016-04-01 00:00:00

abstract：:Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a re...

journal_title：European journal of endocrinology

authors： Jaquet D,Khallouf E,Lévy-Marchal C,Czernichow P

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

journal_title：European journal of endocrinology

authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:To estimate morbidity in Denmark in all patients with GH deficiency (GHD). DESIGN:Morbidity was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in the GHD patients were studied and additional morbidity noted. Diagnoses and dates of admissions were identified in the Nati...

journal_title：European journal of endocrinology

authors： Stochholm K,Laursen T,Green A,Laurberg P,Andersen M,Kristensen LØ,Feldt-Rasmussen U,Christiansen JS,Frydenberg M,Gravholt CH

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Smaller size at birth has been associated with an increased risk of metabolic and cardiovascular disorders in adult life. Fetal programming of the hypothalamic-pituitary-adrenal axis has been suggested as a possible explanation. Fetal glucocorticoid (GC) overexposure has effects that suggest a role of GCs in ...

journal_title：European journal of endocrinology

authors： Manenschijn L,van den Akker EL,Ester WA,Leunissen RW,Willemsen RH,van Rossum EF,Koper JW,Lamberts SW,Hokken-Koelega AC

更新日期：2010-12-01 00:00:00

abstract：:Previous reports of a correlation between serum dehydroepiandrosterone sulfate (DHEAS) and testosterone in both men and women have led to the suggestion that adrenal and gonadal secretion are related. In the present study, the correlation of DHEAS with testosterone and free testosterone (FT) in both normal men and wom...

journal_title：European journal of endocrinology

authors： Phillips GB

更新日期：1996-02-01 00:00:00

abstract：:Low levels of insulin-like growth factor I (IGF-I) in critical illness are observed despite increased or normal levels of growth hormone (GH). The mechanisms for this apparent GH resistance have not been elucidated. As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cyt...

journal_title：European journal of endocrinology

authors： Wolf M,Böhm S,Brand M,Kreymann G

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:The purpose of this population-based prospective cohort study was to examine the effect of hormone therapy (HT) on incidence of diabetes mellitus (DM). DESIGN AND METHODS:Eight thousand four hundred and eighty-three DM-free post-menopausal women aged 52-62 from the population-based Kuopio osteoporosis risk ...

journal_title：European journal of endocrinology

authors： Pentti K,Tuppurainen MT,Honkanen R,Sandini L,Kröger H,Alhava E,Saarikoski S

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To examine local actions of nitric oxide (NO) on the neural mechanisms controlling the release of vasopressin (AVP) and the cardiovascular system in the anteroventral third ventricular region (AV3V), a pivotal area for autonomic functions, and to pursue the problem of whether it may have any role in the AVP a...

journal_title：European journal of endocrinology

authors： Yamaguchi K,Watanabe K,Yamaya K

更新日期：2000-10-01 00:00:00

abstract：:Thyrotropin (TSH)-secreting adenomas (TSHomas) are the rarest form of pituitary adenomas, and most endocrinologists will see few cases in a lifetime, if any. In most cases, the diagnostic approach is complicated and cases may be referred after being presented as a syndrome of inappropriate TSH secretion or as a pituit...

journal_title：European journal of endocrinology

authors： Tjörnstrand A,Nyström HF

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIM:Several basic science studies support the existence of non-genomic glucocorticoid signaling in pancreas, liver, and adipocytes, but its clinical relevance has not yet been elucidated. This study aimed at investigating the rapid effects of hydrocortisone on the human metabolic response to glucose. SU...

journal_title：European journal of endocrinology

authors： Vila G,Krebs M,Riedl M,Baumgartner-Parzer SM,Clodi M,Maier C,Pacini G,Luger A

更新日期：2010-08-01 00:00:00

abstract：:We report our experience in treating growth delay in boys with isolated growth hormone deficiency (IGHD) receiving biosynthetic human growth hormone. The study was performed in 15 boys with IGHD receiving GH. At the chronological age of 13.1 (1.1) years (SD), 13 were prepubertal, two were in early puberty and there wa...

journal_title：European journal of endocrinology

authors： Albanese A,Stanhope R

更新日期：1994-01-01 00:00:00

abstract：:We here investigate the potential rescue of the relative hyposomatotropism of aging and obesity by 3-day pulsatile GHRH infusions (i.v. bolus 0.33 microg/kg every 90 min) in 19 healthy men of varying ages (18 to 66 years) and body compositions (12 to 37% total body fat). Baseline (control) and GHRH-driven pulsatile GH...

journal_title：European journal of endocrinology

authors： Iranmanesh A,South S,Liem AY,Clemmons D,Thorner MO,Weltman A,Veldhuis JD

更新日期：1998-07-01 00:00:00

abstract：:Puberty is the result of increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity. In general in females, development of secondary sex characteristics due to the activity of the gonadal axis, i.e., the growth of...

journal_title：European journal of endocrinology

authors： Delemarre EM,Felius B,Delemarre-van de Waal HA

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Surgery remains a common form of treatment for sellar and parasellar tumors involving the pituitary gland and adjacent structures. Studies have suggested that pituitary surgery procedures performed at high-volume centers are associated with less adverse outcomes, yet it remains unclear which types of patients...

journal_title：European journal of endocrinology

authors： Mukherjee D,Zaidi HA,Kosztowski T,Chaichana KL,Salvatori R,Chang DC,Quiñones-Hinojosa A

更新日期：2009-08-01 00:00:00

abstract：:We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonado...

journal_title：European journal of endocrinology

authors： Benvenga S,Smedile G,Lo Giudice F,Trimarchi F

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The uncoupling protein 2 (UCP2) uncouples respiration from the oxidative phosphorylation in most cell types, predominantly in white fat and skeletal muscle. Since a decreased basal metabolic rate (BMR) would increase the susceptibility to weight gain, genetic alterations in the UCP2 gene could contribute to t...

journal_title：European journal of endocrinology

authors： Klannemark M,Orho M,Groop L

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:We intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents. METHODS:The study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had thei...

journal_title：European journal of endocrinology

authors： Soriano-Guillén L,Hernández-García B,Pita J,Domínguez-Garrido N,Del Río-Camacho G,Rovira A

更新日期：2008-07-01 00:00:00

abstract：CONTEXT:The TIMES2 (testosterone replacement in hypogonadal men with either metabolic syndrome or type 2 diabetes) study reported beneficial effects of testosterone replacement therapy (TRT) on insulin resistance and other variables in men with diabetes or metabolic syndrome. The androgen receptor CAG repeat polymorphi...

journal_title：European journal of endocrinology

authors： Stanworth RD,Akhtar S,Channer KS,Jones TH

更新日期：2013-12-21 00:00:00

abstract：CONTEXT:The urea cycle is a rate-limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole-body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE:To determin...

journal_title：European journal of endocrinology

authors： Lam T,Poljak A,McLean M,Bahl N,Ho KKY,Birzniece V

更新日期：2017-04-01 00:00:00

abstract：:We report the clinical history and results of endocrine investigations in two brothers born to consanguineous parents, who presented with hypokalemia and arterial hypertension when they were aged 2 and 6 years. The hormonal serum assay results, including extremely low values for aldosterone and plasma renin activity, ...

journal_title：European journal of endocrinology

authors： Gourmelen M,Saint-Jacques I,Morineau G,Soliman H,Julien R,Fiet J

更新日期：1996-08-01 00:00:00

abstract：:As differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of disease, so that previous follow-up protocols based mostly on data ...

journal_title：European journal of endocrinology

authors： Schlumberger M,Pacini F,Wiersinga WM,Toft A,Smit JW,Sanchez Franco F,Lind P,Limbert E,Jarzab B,Jamar F,Duntas L,Cohen O,Berg G

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. PA...

journal_title：European journal of endocrinology

authors： Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:In men, the feedback of gonadotropins is regulated by estrogens that come from the aromatization of testosterone, but the relative contribution to the inhibition of LH and FSH secretion by the amount of locally produced estrogens within the hypothalamus and/or the pituitary, and the amount of circulating est...

journal_title：European journal of endocrinology

authors： Rochira V,Zirilli L,Genazzani AD,Balestrieri A,Aranda C,Fabre B,Antunez P,Diazzi C,Carani C,Maffei L

更新日期：2006-10-01 00:00:00