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Acute effects of hydrocortisone on the metabolic response to a glucose load: increase in the first-phase insulin secretion.

Abstract：

BACKGROUND AND AIM:Several basic science studies support the existence of non-genomic glucocorticoid signaling in pancreas, liver, and adipocytes, but its clinical relevance has not yet been elucidated. This study aimed at investigating the rapid effects of hydrocortisone on the human metabolic response to glucose. SUBJECTS AND METHODS:In a randomized placebo-controlled crossover study, ten healthy men received an i.v. bolus of 0.6 mg/kg hydrocortisone once and placebo once 4 min before the administration of 330 mg/kg glucose. Cortisol, glucose, insulin, C-peptide, ghrelin, and peptide YY (PYY) levels were measured during the following 3 h. Minimal model analysis was performed for evaluating the metabolic response. RESULTS:Hydrocortisone attenuated the rise in plasma glucose during the initial 15 min following glucose administration (P=0.039), and it led to lower glucose levels during the first 2 h (P=0.017). This was accompanied by enhanced circulating insulin (P=0.02) and C-peptide (P=0.03) levels during the initial 15 min, and a 35% increase in the first-phase beta-cell function (P=0.003). Hydrocortisone decreased PYY concentrations during the initial 30 min (P=0.014), but it did not affect the ghrelin response to glucose. CONCLUSION:One i.v. bolus of hydrocortisone induces rapid effects on carbohydrate metabolism increasing the first-phase beta-cell function. The modulation of PYY plasma levels suggests the possible non-genomic effects of glucocorticoids on appetite-regulatory hormones.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Vila G,Krebs M,Riedl M,Baumgartner-Parzer SM,Clodi M,Maier C,Pacini G,Luger A

doi

10.1530/EJE-10-0282

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

225-31

issue

2

eissn

0804-4643

issn

1479-683X

pii

EJE-10-0282

journal_volume

163

pub_type

杂志文章,随机对照试验

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