Abstract:
OBJECTIVE:To assess whether TCF7L2 single nucleotide polymorphisms rs7903146 C/T and rs11196236 C/T are associated with polycystic ovary syndrome (PCOS) in South Brazilian women. DESIGN:Cross-sectional study. METHODS:Two hundred PCOS patients and 102 non-hirsute, ovulatory controls were genotyped by real-time PCR. Haplotypes were constructed from the combination of both polymorphisms. Frequencies were inferred using the PHASE 2.1.1 software. RESULTS AND CONCLUSIONS:The distribution of rs7903146 (PCOS, 54.4% CC; 28.5% CT; 17.1% TT; controls, 51.0% CC; 37.0% CT; 12.0% TT) and rs11196236 (PCOS, 4.3% CC; 33.5% CT; 62.2% TT; controls, 3.2% CC; 35.5% CT; 61.3% TT) was similar between the groups. rs7903146 and rs11196236 were not in linkage disequilibrium (|D'|=0.34; r(2)=0.07). PCOS participants were younger, with higher age-adjusted BMI, waist circumference, blood pressure, triglycerides, insulin, homeostasis model assessment index to estimate insulin resistance and total testosterone, and lower HDL-C and sex hormone binding globulin vs controls. In PCOS, no differences between genotypes and haplotypes were found for clinical and metabolic variables. However, for each T (rs7903146) and T (rs11196236) allele added to the haplotypes, a variation of 5.87 cm in waist (P trend=0.01), 10.7 mg/dl in total cholesterol (P trend=0.03), and 10.3 mg/dl in LDL-C (P trend=0.01) was recorded. TCF7L2 variants are probably not implicated in PCOS development in South Brazilian women.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Ramos RB,Wiltgen D,Spritzer PMdoi
10.1530/EJE-13-0105subject
Has Abstractpub_date
2013-10-01 00:00:00pages
569-76issue
5eissn
0804-4643issn
1479-683Xpii
EJE-13-0105journal_volume
169pub_type
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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更新日期:2005-04-01 00:00:00
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doi:10.1530/eje.0.1440529
更新日期:2001-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-13-0136
更新日期:2013-07-13 00:00:00
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doi:10.1530/eje.0.1420445
更新日期:2000-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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更新日期:2003-04-01 00:00:00