Abstract:
OBJECTIVE:KLF7 encodes Krüppel-like factor (KLF) 7, a member of the KLF family of transcription factors, initially shown to play important roles in cellular development and differentiation, and reported to be specifically involved in adipogenesis. Several single nucleotide polymorphisms (SNPs) have been identified in KLF7, of which the A-allele of rs2302870 has been associated with type 2 diabetes in a Japanese population; however, a possible association of KLF7 SNPs with obesity has not been investigated. We aimed to identify variation in the putative promoter region, the coding regions, exon/intron boundaries, and 3'-UTR of KLF7, and to examine identified variants in relation to obesity, type 2 diabetes, and related quantitative traits in Danish individuals. METHODS:Identified variants were investigated for association with type 2 diabetes in 8777 individuals and with obesity in 14 818 individuals. RESULTS:We identified four common SNPs in low pairwise linkage disequilibrium; three in the putative promoter region (-1119 G>A, -963 C>A (rs7568369), and -614 G>A) and IVS2+35092 A>C (rs2302870). We failed to confirm an association between rs2302870 and type 2 diabetes. Neither was rs7568369 associated with type 2 diabetes; however, the minor A-allele of rs7568369 protected against obesity (OR=0.90 (0.84-0.96), P=0.001) and in studies of quantitative traits (n=5,535) the variant associated with decreased body mass index (P=0.002) and waist circumference (P=0.003). The -1119 G>A and -614 G>A variants were not associated with obesity or type 2 diabetes. CONCLUSION:We identified a novel association between the minor A-allele of KLF7 rs7568369 and protection against obesity in the Danish population.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Zobel DP,Andreasen CH,Burgdorf KS,Andersson EA,Sandbaek A,Lauritzen T,Borch-Johnsen K,Jørgensen T,Maeda S,Nakamura Y,Eiberg H,Pedersen O,Hansen Tdoi
10.1530/EJE-08-0688subject
Has Abstractpub_date
2009-04-01 00:00:00pages
603-9issue
4eissn
0804-4643issn
1479-683Xpii
EJE-08-0688journal_volume
160pub_type
杂志文章abstract:OBJECTIVE:Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs m...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.01913
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1530/eje.0.1500719
更新日期:2004-05-01 00:00:00
abstract::Osteopetrosis is a rare metabolic bone disease characterized by a generalized increase in skeletal mass. It is inherited in a number of mammalian species, including man, and results from a congenital defect in the development or function of the osteoclasts. The consequent impairment of bone resorption prevents formati...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.1340143
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0246
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abstract:OBJECTIVE:Epigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible and therefore an interesting therapeutic target. Multiple endocrine neo...
journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0355
更新日期:2007-12-01 00:00:00
abstract::Low levels of insulin-like growth factor I (IGF-I) in critical illness are observed despite increased or normal levels of growth hormone (GH). The mechanisms for this apparent GH resistance have not been elucidated. As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cyt...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1350729
更新日期:1996-12-01 00:00:00
abstract:CONTEXT:Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women. No previous study on long-term GH therapy in adults with childhood onset (CO) craniopharyngioma was identified. OBJECTIVE:To investigate CVD risk in adults with CO craniopharyn...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0449
更新日期:2009-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1470133
更新日期:2002-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02038
更新日期:2005-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
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更新日期:2005-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1380164
更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EJE-11-0545
更新日期:2011-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02145
更新日期:2006-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1480597
更新日期:2003-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1330327
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pub_type: 杂志文章,评审
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更新日期:2007-07-01 00:00:00
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journal_title:European journal of endocrinology
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更新日期:2011-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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更新日期:2018-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1380227
更新日期:1998-02-01 00:00:00
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更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00