Abstract:
OBJECTIVE:To detect exogenous recombinant human GH (rhGH) abuse in female athletes. DESIGN:GH-dependent markers were assayed in serum of 100 female athletes (control group) and in a subgroup of nine female subjects treated with rhGH (0.09 IU/kg body weight, 6 days/week for 3 weeks). METHODS:Cut-off values (mean+2 s.d.) for IGF1, N-terminal propeptide of type III procollagen (PIIINP) and C-terminal telopeptide of type I collagen (ICTP) were calculated and arbitrary scores (1.5 or 2.0) were assigned to abnormal markers. By using the sum of individual marker scores, positive (> or =3) or negative (<3) scores were obtained. RESULTS:None of the control group obtained a positive score (> or =3). Abnormal IGF1, PIIINP and ICTP levels were found in 61.4, 54.5 and 11.4% samples of the treated group. Overall, positive cases were present in 43.2% blood samples drawn in subjects treated with rhGH and in 26% of samples after rhGH withdrawal. The sensitivity of the detection approach was 66.6% at the end of 3-week rhGH treatment and 11.1% at the 15th day of rhGH withdrawal, while the specificity was 100%. CONCLUSION:Detection test for rhGH administration appears less sensitive in female (66.6%) than in male athletes (previous observation, 100% after 3 weeks of comparable rhGH dose), but shows a similar specificity (98.5-100%). Since athletes supposedly use very high doses and long-term administration of rhGH for doping purposes, it is foreseen that the here-in detection test would in future increase its strength.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Di Luigi L,Rigamonti AE,Agosti F,Mencarelli M,Sgrò P,Marazzi N,Cella SG,Müller EE,Sartorio Adoi
10.1530/EJE-08-0884subject
Has Abstractpub_date
2009-05-01 00:00:00pages
753-8issue
5eissn
0804-4643issn
1479-683Xpii
EJE-08-0884journal_volume
160pub_type
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更新日期:1999-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-10-01 00:00:00
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更新日期:2014-04-10 00:00:00
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更新日期:2014-06-01 00:00:00
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更新日期:1999-11-01 00:00:00
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更新日期:2014-03-08 00:00:00
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更新日期:2005-05-01 00:00:00