Abstract:
BACKGROUND:Epidemiological studies suggest that hypopituitary patients have an increased risk for cardiovascular mortality. The dyslipidaemia associated with this condition is often characterised by an increase in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol (LDL-C) and may contribute to these findings. The underlying mechanisms are not fully elucidated. MATERIALS AND METHODS:LDL apolipoprotein B (apoB) production rate and metabolic clearance rate were measured in seven patients with hypopituitarism (including GH deficiency) under stable conventional replacement therapy (three males and four females; age 40-16.1 years; body mass index 29.0-6.1 kg/m(2) (means +/- s.d.)) and seven age-, gender- and body mass index-matched control subjects with an infusion of 1-(13)C-leucine. Fasting lipid profile and lipid composition of LDL were also measured. RESULTS:Fasting TC, triglycerides (TG), high-density lipoprotein-C, LDL-C and free fatty acid concentrations were not different between hypopituitary patients and control subjects. LDL-TG (P < 0.006) and LDL-TG/LDL apoB ratio (P < 0.02) were significantly increased in hypopituitary patients. LDL apoB pool size was not statistically different between patients and control subjects. In the hypopituitary patients, LDL apoB metabolic clearance rate (P < 0.05) and LDL apoB production rate (P < 0.02) were lower than in the control subjects. CONCLUSIONS:The present results suggest that LDL apoB turnover and LDL composition is altered in hypopituitary patients. Whether these findings explain the increased risk for cardiovascular disease in hypopituitary patients remains to be established.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Christ ER,Cummings MH,Stolinski M,Jackson N,Lumb PJ,Wierzbicki AS,Sönksen PH,Russell-Jones DL,Umpleby AMdoi
10.1530/eje.1.02105subject
Has Abstractpub_date
2006-03-01 00:00:00pages
459-66issue
3eissn
0804-4643issn
1479-683Xpii
154/3/459journal_volume
154pub_type
杂志文章abstract::X-linked adrenoleucodystrophy (ALD) has been shown to be one of the most frequent causes of Addison's disease in men. It is characterized by an impaired peroxisomal beta-oxidation of very long chain fatty acids and is associated with mutations of the ALD gene resulting in a defective peroxisomal membrane transport pro...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1370040
更新日期:1997-07-01 00:00:00
abstract:CONTEXT AND OBJECTIVE:Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin...
journal_title:European journal of endocrinology
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doi:10.1530/EJE-08-0069
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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doi:10.1530/EJE-10-1095
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The aromatization of androgenic precursors is the main source of estrogens in postmenopausal women. We tested the hypothesis that allelic variants of the genes coding for aromatase and estrogen receptors (ER) could interact to determine the estrogenic signals on the bone tissue and, consequently, bone mineral...
journal_title:European journal of endocrinology
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doi:10.1530/eje.1.02189
更新日期:2006-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2019-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1340710
更新日期:1996-06-01 00:00:00
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journal_title:European journal of endocrinology
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doi:10.1530/EJE-20-1180
更新日期:2020-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1330591
更新日期:1995-11-01 00:00:00
abstract::Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40 mm or more, signi...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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journal_title:European journal of endocrinology
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更新日期:2003-04-01 00:00:00
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更新日期:2005-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0545
更新日期:2011-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1310652
更新日期:1994-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-12-10 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.01891
更新日期:2005-04-01 00:00:00
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更新日期:2016-06-01 00:00:00
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journal_title:European journal of endocrinology
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更新日期:1998-03-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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