DIAGNOSIS OF ENDOCRINE DISEASE: Diagnostic approach to TSH-producing pituitary adenoma.

abstract：OBJECTIVE:In the field of fine-needle aspiration cytology, the category of suspicious for malignancy (SM) thyroid lesions, that bears 55-85% risk of malignant histology, is a challenging topic in which morphology alone is not always able to make a correct diagnosis. Recently, immunocytochemistry (ICC) has been referred...

journal_title：European journal of endocrinology

authors： Rossi ED,Martini M,Capodimonti S,Straccia P,Cenci T,Lombardi CP,Pontecorvi A,Larocca LM,Fadda G

更新日期：2013-05-02 00:00:00

abstract：OBJECTIVE:In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or component-specific effects on cardiac gene expression. DESIGN:Rats were treated with AM or Dron and the expression of TRalpha 1, TRalpha ...

journal_title：European journal of endocrinology

authors： Stoykov I,van Beeren HC,Moorman AF,Christoffels VM,Wiersinga WM,Bakker O

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Autoimmune polyendocrine syndrome type I (APS I) is a monogenic disease affecting endocrine glands and other organs due to mutations of the autoimmune regulator (AIRE) gene. There is a wide variability in clinical phenotypes in patients with APS I, which makes the diagnosis a challenge. OBJECTIVE:To screen ...

journal_title：European journal of endocrinology

authors： F Magitta N,Pura M,S Bøe Wolff A,Vanuga P,Meager A,M Knappskog P,Husebye ES

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

journal_title：European journal of endocrinology

authors： Salvatori R,Fan X,Veldhuis JD,Couch R

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To assess whether TCF7L2 single nucleotide polymorphisms rs7903146 C/T and rs11196236 C/T are associated with polycystic ovary syndrome (PCOS) in South Brazilian women. DESIGN:Cross-sectional study. METHODS:Two hundred PCOS patients and 102 non-hirsute, ovulatory controls were genotyped by real-time PCR. Ha...

journal_title：European journal of endocrinology

authors： Ramos RB,Wiltgen D,Spritzer PM

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To establish an Inuit body mass index (BMI) norm from a healthy, not malnourished, pure Inuit population and to investigate the development of overweight in the Inuit in Greenland. DESIGN:Longitudinal study with 35 years follow-up on overweight among Inuit in Greenland. METHODS:The heights and weights of 97...

journal_title：European journal of endocrinology

authors： Andersen S,Mulvad G,Pedersen HS,Laurberg P

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...

journal_title：European journal of endocrinology

authors： Mazziotti G,Porcelli T,Bianchi A,Cimino V,Patelli I,Mejia C,Fusco A,Giampietro A,De Marinis L,Giustina A

更新日期：2010-07-01 00:00:00

abstract：:Pyridostigmine (PST), a cholinesterase inhibitor, induces a clear growth hormone (GH) release in man by suppression of hypothalamic somatostatin (SRIH). Somatostatin suppresses thyrotrophin (TSH) release in rats and men. Earlier studies showed that the thryotrophin-releasing hormone (TRH)-induced TSH response was not ...

journal_title：European journal of endocrinology

authors： Yang I,Woo J,Kim S,Kim J,Kim Y,Choi Y

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To correlate anthropometric, computed tomography and fat cell data from abdominal regions with the levels of serum insulin, C-peptide, leptin, tumor necrosis factor-alpha (TNF-alpha), testosterone, 17beta-estradiol, androstenedione, dehydroepiandrosterone sulphate (DHEA-S) and sex hormone-binding globulin (SH...

journal_title：European journal of endocrinology

authors： Garaulet M,Pérex-Llamas F,Fuente T,Zamora S,Tebar FJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. DESIGN:Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. METHO...

journal_title：European journal of endocrinology

authors： Salcuni AS,Carnevale V,Battista C,Palmieri S,Eller-Vainicher C,Guarnieri V,Pugliese F,Guglielmi G,Desina G,Minisola S,Chiodini I,Scillitani A

更新日期：2017-11-01 00:00:00

abstract：:Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

journal_title：European journal of endocrinology

authors： Fanciulli G,Oliva O,Tomasi PA,Pala A,Bertoncelli A,Dettori A,Delitala G

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim o...

journal_title：European journal of endocrinology

authors： Albano D,Bertagna F,Bonacina M,Durmo R,Cerudelli E,Gazzilli M,Panarotto MB,Formenti AM,Mazziotti G,Giustina A,Giubbini R

更新日期：2018-09-01 00:00:00

abstract：CONTEXT:Although combination therapy of acromegaly with long-acting somatostatin analogs (LA-SSAs) and pegvisomant (PEGV) normalizes insulin-like growth factor-1 (IGF1) levels in the majority of patients, it requires long-term adherence. Switching from combination therapy to monotherapy with weekly PEGV could improve p...

journal_title：European journal of endocrinology

authors： Muhammad A,van der Lely AJ,O'Connor RD,Delhanty PJ,Dal J,Dallenga AH,Feelders RA,Janssen JA,Jorgensen JO,Neggers SJ

更新日期：2016-05-01 00:00:00

abstract：:Osteoporosis is being increasingly recognised in paediatric practice as a consequence of several factors. These include the increasing complexity of chronic conditions and the associated treatments managed by paediatricians. In addition, the improved care provided to children with chronic illness has led to many of th...

journal_title：European journal of endocrinology

authors： Shaw NJ

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether patients with Addison's disease and polyendocrine syndromes have undiagnosed autoimmune polyendocrine syndrome type I (APS I). MATERIALS AND METHODS:Forty patients with clinical manifestations resembling APS I and with autoantibodies typical of this condition were screened for Norwegia...

journal_title：European journal of endocrinology

authors： Bøe AS,Knappskog PM,Myhre AG,Sørheim JI,Husebye ES

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

journal_title：European journal of endocrinology

authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

更新日期：2017-07-01 00:00:00

abstract：:The monoclonal origin of gonadotropin-secreting pituitary adenomas has been well demonstrated but only few molecular abnormalities have so far been recognized in these tumors. For many years, several authors have suggested a role for GnRH and/or GnRH receptors (GnRH-R) in the development of these pituitary adenomas. T...

journal_title：European journal of endocrinology

authors： Chanson P,De Roux N,Young J,Bidart JM,Jacquet P,Misrahi M,Milgrom E,Schaison G

更新日期：1998-08-01 00:00:00

abstract：:Patients with adrenal insufficiency need lifelong glucocorticoid replacement, but many suffer from poor quality of life, and overall there is increased mortality. Moreover, it appears that use of glucocorticoids at the higher end of the replacement dose range is associated with increased risk for cardiovascular and me...

journal_title：European journal of endocrinology

authors： Debono M,Ross RJ,Newell-Price J

更新日期：2009-05-01 00:00:00

abstract：:We measured serum concentrations of insulin-like growth factors I and II (IGF-I and IGF-II) by radioimmunoassay in 107 healthy women aged 28-78 years and in 116 women with established osteoporosis. The women with established osteoporosis were randomized to a 1-year double-blind, placebo-controlled treatment with conti...

journal_title：European journal of endocrinology

authors： Ravn P,Overgaard K,Spencer EM,Christiansen C

更新日期：1995-03-01 00:00:00

abstract：:The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

journal_title：European journal of endocrinology

authors： Gründker C,Günthert AR,Westphalen S,Emons G

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Thymic neuroendocrine tumor is the second-most prevalent cause of ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS), which is a rare disease characterized by ectopic ACTH oversecretion from nonpituitary tumors. However, the genetic abnormalities of thymic neuroendocrine tumors with EAS remain largely ...

journal_title：European journal of endocrinology

authors： Li Y,Peng Y,Jiang X,Cheng Y,Zhou W,Su T,Xie J,Zhong X,Song D,Wu L,Fan L,Li M,Hong J,Wang W,Ning G,Cao Y

更新日期：2017-02-01 00:00:00

abstract：:The effects of water deprivation for 3 days were studied in pregnant rats and their fetuses on day 21 of gestation. Maternal water deprivation induced a significant decrease of the body weight in both maternal and fetal rats. This weight loss was accompanied by significant increases in plasma osmolality and haematocri...

journal_title：European journal of endocrinology

authors： Deloof S,De Seze C,Montel V,Chatelain A

更新日期：1999-08-01 00:00:00

abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...

journal_title：European journal of endocrinology

authors： Marek J,Hána V,Krsek M,Justová V,Catus F,Thomas F

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:To assess the effect of age on clinical, endocrine and sonographic features associated with polycystic ovary syndrome (PCOS) in normogonadotrophic anovulatory infertile women of reproductive years. DESIGN:Cross-sectional study. METHODS:Four hundred and seventy-two oligo-amenorrhoeic infertile patients, pres...

journal_title：European journal of endocrinology

authors： Bili H,Laven J,Imani B,Eijkemans MJ,Fauser BC

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...

journal_title：European journal of endocrinology

authors： Rubello D,Piotto A,Casara D,Muzzio PC,Shapiro B,Pelizzo MR

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of ind...

journal_title：European journal of endocrinology

authors： Meyer G,Mayer M,Mondorf A,Fluegel AK,Herrmann E,Bojunga J

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To analyse trends in diagnostic practices of thyroid diseases and to relate them to the increase in thyroid cancer incidence in France over time. DESIGN:From 1980 to 2000, a French retrospective multicentric (three endocrinology and three nuclear medicine centres) study of thyroid diseases was conducted on 2...

journal_title：European journal of endocrinology

authors： Leenhardt L,Bernier MO,Boin-Pineau MH,Conte Devolx B,Maréchaud R,Niccoli-Sire P,Nocaudie M,Orgiazzi J,Schlumberger M,Wémeau JL,Chérie-Challine L,De Vathaire F

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

journal_title：European journal of endocrinology

authors： Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Although fibroblast growth factor 23 (FGF23) has been implicated in the pathogenesis of cardiovascular disease, the relationship between FGF23 and cardiovascular disease has not been well characterized in the general population. The aim of this study was to determine whether serum FGF23 is independently assoc...

journal_title：European journal of endocrinology

authors： Dalal M,Sun K,Cappola AR,Ferrucci L,Crasto C,Fried LP,Semba RD

更新日期：2011-11-01 00:00:00

abstract：:Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the hu...

journal_title：European journal of endocrinology

authors： Giovanella L,Clark PM,Chiovato L,Duntas L,Elisei R,Feldt-Rasmussen U,Leenhardt L,Luster M,Schalin-Jäntti C,Schott M,Seregni E,Rimmele H,Smit J,Verburg FA

更新日期：2014-08-01 00:00:00