Abstract:
OBJECTIVE:To analyse trends in diagnostic practices of thyroid diseases and to relate them to the increase in thyroid cancer incidence in France over time. DESIGN:From 1980 to 2000, a French retrospective multicentric (three endocrinology and three nuclear medicine centres) study of thyroid diseases was conducted on 20 consecutive unselected patients' records, sampled every 5 years in each centre. METHODS:Characteristics of the population and diagnosis procedures (thyroid ultrasonography (US), radionuclide scan, cytology and hormonal measurements) were described over time. Changing trends in operated patients and in cancer prevalence were analysed as well as the impact of practices on cancer incidence. RESULTS:The study included 471 patients (82% female, mean age 46.7, range 9-84 years), referred for nodular thyroid diseases (66.7%) or thyroid dysfunctions (33.3%). A significant increase in US (3 to 84.8%) and cytological practices (4.5 to 23%), and a decrease (89.4 to 49.6%) in radionuclide scan procedures were observed over time. Although the proportion of patients undergoing surgery remained constant (24.8%), the prevalence of cancer increased among operated patients from 12.5 to 37% (P=0.006). In a Cox's proportional hazard model stratified on the clinical characteristics of patients, only the cytological practice, regardless of its results, was significantly associated with the occurrence of cancer: relative risk (RR)=4.4 (95% confidence interval (CI): 1.1-16; P=0.04). CONCLUSIONS:From 1980 to 2000, a major evolution in clinical practices has led to the increase in thyroid cancer reported in France. Such changes in medical, as well as in surgical and pathological, practices must be taken into account in incidence measurement.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Leenhardt L,Bernier MO,Boin-Pineau MH,Conte Devolx B,Maréchaud R,Niccoli-Sire P,Nocaudie M,Orgiazzi J,Schlumberger M,Wémeau JL,Chérie-Challine L,De Vathaire Fdoi
10.1530/eje.0.1500133subject
Has Abstractpub_date
2004-02-01 00:00:00pages
133-9issue
2eissn
0804-4643issn
1479-683Xpii
1500133journal_volume
150pub_type
杂志文章,多中心研究abstract::Children with cystic fibrosis (CF) have problems with poor linear growth and inadequate weight gain. Nutritional augmentation has been the mainstay of therapy for improving both weight and height in CF; however, inadequate growth continues to be a problem. Furthermore, protein catabolism has been documented even in no...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.151s081
更新日期:2004-08-01 00:00:00
abstract::Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the hu...
journal_title:European journal of endocrinology
pub_type: 共识发展会议,杂志文章,评审
doi:10.1530/EJE-14-0148
更新日期:2014-08-01 00:00:00
abstract::Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-e...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-17-0054
更新日期:2017-04-01 00:00:00
abstract:UNLABELLED:In healthy boys, the pituitary-gonadal axis exhibits diurnal variation in early puberty. Serum testosterone levels are higher during the night and low or immeasurable during the day. These fluctuating levels of circulating androgens in early pubertal boys are difficult to monitor. Prostate specific antigen (...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1360401
更新日期:1997-04-01 00:00:00
abstract::Four groups(N = 3 per group) of juvenile rhesus monkeys (Macaca mulatta, 14-20 months old) received either vehicle or highly purified human follicle-stimulating hormone (FSH; 10 IU kg-1 day-1), human chorionic gonadotropin (hCG; 250 IU every alternate day) or both hormones for a period of 4 weeks. Testicular volume an...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1330235
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-10-0245
更新日期:2010-10-01 00:00:00
abstract::We examined excretion of urinary insulin-like growth factors I and II (IGF-I and IGF-II) and their major binding protein IGFBP-3 in comparison to their respective serum concentration in nine healthy female volunteers (median age 25 years, range 22-27) under baseline conditions and after stimulation with recombinant hu...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/eje.0.1320433
更新日期:1995-04-01 00:00:00
abstract::This is a brief review of the normal changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker for an individual's transition from a non-reproduc...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.151u151
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1420263
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Although vascular mortality is increased in hypopituitary adults on routine replacement, there are limited data on the atherosclerotic process during life in these patients. Measurement of arterial stiffness may provide an index of early vascular changes that predispose to the development of major vascular ac...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1360157
更新日期:1997-02-01 00:00:00
abstract::This study compared plasma concentrations of adrenocorticotropin (ACTH) and cortisol in young men (N = 10, mean age 24.4 years), young women (N = 10, mean age 25.4 years), old men (N = 8, mean age 81.6 years) and old women (N = 8, mean age 83.5 years) under basal resting conditions and after stimulation with either hu...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1320705
更新日期:1995-06-01 00:00:00
abstract::Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-19-0058
更新日期:2019-07-01 00:00:00
abstract::Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1410521
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Changes in many gastrointestinal peptides, including the anorexigenic peptide YY (PYY), which is produced by L cells, occur in both anorexia nervosa (AN) and obesity (OB). High PYY levels are present in AN, whereas in morbid OB fasting and postprandial PYY secretion is blunted. Somatostatin (somatotropin rele...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0312
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfun...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0555
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures and thiazolidinediones (TZDs) increase this risk. TZDs stimulate the expression of sclerostin, a negative regulator of bone formation, in vitro. Abnormal sclerostin production may, therefore, be involved in the pathogenesis of i...
journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1530/EJE-11-1061
更新日期:2012-04-01 00:00:00
abstract::Glucose transporter-1 (GLUT1) has been found in high abundance in human placentas. The purpose of this study was to analyze the changes in the level of GLUT1 during pregnancy. We have analyzed the gestational changes in human placental GLUT1 by [3H]cytochalasin B binding assay, immunoblot analysis and Northern blot an...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1320206
更新日期:1995-02-01 00:00:00
abstract::Evidence suggests that insulin resistance and hyperinsulinaemia are associated with ovarian hyperandrogenism and menstrual irregularities in polycystic ovary syndrome (PCOS). Sixteen obese women with PCOS on a weight-maintaining diet were studied before and after 6 months of therapy with the insulin-sensitizing antidi...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/eje.0.1380269
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-13-0306
更新日期:2013-09-12 00:00:00
abstract::Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical efficacy and the safety profile of ...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-16-0552
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:In genetically predisposed individuals, exogenous factors (including pollution) influence the development of Hashimoto's thyroiditis/chronic lymphocytic thyroiditis (CLT). CLT may also be a risk factor for associated thyroid cancer. Few data are available on the role of pollution from petrochemical complex...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-14-0864
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Autoimmune polyendocrine syndrome type I (APS I) is a monogenic disease affecting endocrine glands and other organs due to mutations of the autoimmune regulator (AIRE) gene. There is a wide variability in clinical phenotypes in patients with APS I, which makes the diagnosis a challenge. OBJECTIVE:To screen ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0843
更新日期:2008-05-01 00:00:00
abstract::The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.1440319
更新日期:2001-04-01 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN 1) is a familial syndrome characterized by parathyroid, enteropancreatic and pituitary tumors. The gene responsible for this syndrome is localized at chromosomal 11q13 region and DNA markers from this region cosegregate with the disease. The recent identification of the MEN1 ge...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1420131
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Epidemiological studies suggest that hypopituitary patients have an increased risk for cardiovascular mortality. The dyslipidaemia associated with this condition is often characterised by an increase in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol (LDL-C) and may contribute to these f...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02105
更新日期:2006-03-01 00:00:00
abstract:Introduction:Pathologically high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly are associated with arthropathy. Several studies highlight the potential role of the GH/IGF-1 axis in primary osteoarthritis (OA). We aimed to disentangle the role of IGF-1 levels in primary ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-20-0904
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-08-0339
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Multiple types of voltage-activated Ca(2+) channels (T, L, N, P, Q and R type) coordinate a variety of Ca(2+)-dependent processes in neurons and neuroendocrine cells. In insulinoma cell lines as well as in endocrine tissues, the non-L-type alpha1E (Ca(v)2.3) subunit is expressed as the tissue-specific splice ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1460881
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:Adrenocortical tumors may originate from the zona glomerulosa, zona fasciculata, or zona reticularis and be associated with syndromes due to overproduction of mineralocorticoids, glucocorticoids, or androgens respectively. We report an unusual case of recurrent adrenocortical carcinoma (ACC), which seems to c...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02011
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To control postprandial hyperglycemia in insulin-treated type 2 diabetic patients, prandial therapy with regular human insulin (HI) or fast acting insulin analogs is used. Postprandial hyperglycemia seems to be reduced more effectively with insulin analogs than with normal insulin, but there are no data conce...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0061
更新日期:2011-08-01 00:00:00