Endocrine control of testicular somatic and premeiotic germ cell development in the immature testis of the primate Macaca mulatta.


:Four groups(N = 3 per group) of juvenile rhesus monkeys (Macaca mulatta, 14-20 months old) received either vehicle or highly purified human follicle-stimulating hormone (FSH; 10 IU kg-1 day-1), human chorionic gonadotropin (hCG; 250 IU every alternate day) or both hormones for a period of 4 weeks. Testicular volume and weight increased more than twofold after single and more than sixfold after combined hormone treatment. Serum and intratesticular testosterone were at supraphysiological levels in hCG-treated animals and rose even more after combined treatment; a minor elevation of intratesticular testosterone was also observed after FSH treatment. Serum inhibin was elevated after hCG or FSH treatment and increased more than twofold during the first 3 weeks of combined treatment. Semiquantitative analysis of cell numbers showed a statistically non-significant increase in Sertoli cells and Ad- and Ap-spermatogonia after single hormone treatment. Combined treatment induced a further increase in the number of spermatogonia. Leydig cells were only encountered after hCG treatment; their number was more than threefold higher after combined treatment compared with hCG alone. Follicle-stimulating hormone stimulated Sertoli cell and Ap spermatogonia proliferation but did not induce morphological differentiation of Sertoli cells, peritubular cells or Leydig cells. Human CG treatment, however, induced Sertoli cell proliferation and morphological differentiation. It had effects on spermatogonial proliferation but induced differentiation of peritubular cells. Combined treatment initiated the greatest morphological and functional differentiation of Sertoli cells, peritubular cells, Leydig cells and spermatogonia. Flow cytometric analysis confirms an increase of mitotically active cells. The observations show that FSH and testosterone can induce Sertoli cell proliferation. Morphological differentiation of Sertoli cells may be mediated indirectly by environmental and paracrine stimuli released from peritubular cells, whose differentiation is androgen dependent. Leydig cells are stimulated mainly by hCG. Our present and previous data lead us to propose that FSH contributes to the final number and activity of Leydig cells, which secrete immunoreactive inhibin in response to hCG.(ABSTRACT TRUNCATED AT 400 WORDS)


Eur J Endocrinol


Schlatt S,Arslan M,Weinbauer GF,Behre HM,Nieschlag E




Has Abstract


1995-08-01 00:00:00












  • Bone mineral density in middle-aged women with Turner's syndrome.

    abstract::Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 +/- 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Sylvén L,Hagenfeldt K,Ringertz H

    更新日期:1995-01-01 00:00:00

  • Association between monoallelic TSHR mutations and congenital hypothyroidism: a statistical approach.

    abstract:OBJECTIVE:Biallelic TSHR mutations cause congenital hypothyroidism (CH). Serum TSH levels of monoallelic mutation carriers range from normal to mildly elevated, and thus the size of its effect remains unclear. The objectives were to examine the association between monoallelic TSHR mutations and positivity at newborn sc...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Abe K,Narumi S,Suwanai AS,Adachi M,Muroya K,Asakura Y,Nagasaki K,Abe T,Hasegawa T

    更新日期:2018-02-01 00:00:00

  • Monocentric study of 112 consecutive patients with childhood onset GH deficiency around and after transition.

    abstract:OBJECTIVES:Our aim was to analyze a large cohort of childhood onset GH deficiency (CO-GHD) adults from a unique adult center, in order to analyze their clinical management and to study the metabolic and bone status in relation to GHD and to the other pituitary deficits, and to evaluate these parameters during the long-...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Courtillot C,Baudoin R,Du Souich T,Saatdjian L,Tejedor I,Pinto G,Léger J,Polak M,Golmard JL,Touraine P,Transition GHD Group.

    更新日期:2013-10-01 00:00:00

  • Partial restoration of GH responsiveness to ghrelin in Cushing's disease after 6 months of ketoconazole treatment: comparison with GHRP-6 and GHRH.

    abstract:OBJECTIVE:In Cushing's disease (CD), GH responsiveness to several stimuli, including ghrelin, GHRP-6, and GHRH, is blunted. Recovery of GH secretion after remission of hypercortisolism after transsphenoidal surgery, radiotherapy, or adrenalectomy is controversial. There are no studies evaluating the effect of primary c...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Correa-Silva SR,Nascif SO,Molica P,Sá LB,Vieira JG,Lengyel AM

    更新日期:2009-11-01 00:00:00

  • Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men.

    abstract::We here investigate the potential rescue of the relative hyposomatotropism of aging and obesity by 3-day pulsatile GHRH infusions (i.v. bolus 0.33 microg/kg every 90 min) in 19 healthy men of varying ages (18 to 66 years) and body compositions (12 to 37% total body fat). Baseline (control) and GHRH-driven pulsatile GH...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Iranmanesh A,South S,Liem AY,Clemmons D,Thorner MO,Weltman A,Veldhuis JD

    更新日期:1998-07-01 00:00:00

  • Fractionated radiotherapy and radiosurgery in acromegaly: analysis of 352 patients from the German Acromegaly Registry.

    abstract:Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

    更新日期:2020-03-01 00:00:00

  • Hyperandrogenism after menopause.

    abstract::Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evalua...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Markopoulos MC,Kassi E,Alexandraki KI,Mastorakos G,Kaltsas G

    更新日期:2015-02-01 00:00:00

  • Association of antiepileptic drug usage, trace elements and thyroid hormone status.

    abstract:BACKGROUND:Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Zevenbergen C,Korevaar TI,Schuette A,Peeters RP,Medici M,Visser TJ,Schomburg L,Visser WE

    更新日期:2016-04-01 00:00:00

  • Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI.

    abstract:OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

    更新日期:2016-11-01 00:00:00

  • Can we predict relapse in Graves' disease? Results from a systematic review and meta-analysis.

    abstract:BACKGROUND:Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options. PURPOSE:We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD i...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,meta分析,评审


    authors: Struja T,Fehlberg H,Kutz A,Guebelin L,Degen C,Mueller B,Schuetz P

    更新日期:2017-01-01 00:00:00

  • Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery.

    abstract::The episodicity of 24 h GH release was studied in 18 patients with active acromegaly, 12 patients 7-10 days after pituitary surgery, 14 patients long after operation (3-17 years), and 21 healthy gender- and age-matched control subjects, using a recently introduced scale- and model-independent regularity statistic, app...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: van den Berg G,Pincus SM,Frölich M,Veldhuis JD,Roelfsema F

    更新日期:1998-02-01 00:00:00

  • Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.

    abstract:OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures and thiazolidinediones (TZDs) increase this risk. TZDs stimulate the expression of sclerostin, a negative regulator of bone formation, in vitro. Abnormal sclerostin production may, therefore, be involved in the pathogenesis of i...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: van Lierop AH,Hamdy NA,van der Meer RW,Jonker JT,Lamb HJ,Rijzewijk LJ,Diamant M,Romijn JA,Smit JW,Papapoulos SE

    更新日期:2012-04-01 00:00:00

  • Genetic influence of an ACTH receptor promoter polymorphism on adrenal androgen secretion.

    abstract:OBJECTIVE:Adrenocorticotropic hormone (ACTH) is the primary secretagogue stimulating secretion of adrenal androgens (AA). Yet, genetic and environmental factors are assumed to play a determining role in the regulation of their biosynthesis and thus might explain the high variability of AA levels. Here we investigate th...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Reisch N,Slawik M,Zwermann O,Beuschlein F,Reincke M

    更新日期:2005-11-01 00:00:00

  • Growth hormone treatment before the age of 4 years prevents short stature in young girls with Turner syndrome.

    abstract:OBJECTIVE:Adult height deficit seen in Turner syndrome (TS) originates, in part, from growth retardation in utero and throughout the first 3 years of life. Earlier diagnosis enables earlier therapeutic intervention, such as with recombinant human GH (r-hGH), which may help to prevent growth retardation. In this open-la...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Linglart A,Cabrol S,Berlier P,Stuckens C,Wagner K,de Kerdanet M,Limoni C,Carel JC,Chaussain JL,French Collaborative Young Turner Study Group.

    更新日期:2011-06-01 00:00:00

  • Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene.

    abstract:OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Salvatori R,Fan X,Veldhuis JD,Couch R

    更新日期:2002-11-01 00:00:00

  • Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition.

    abstract:OBJECTIVE:In males, the pubertal increase in sex hormone production has been associated with proatherogenic changes in lipid and carbohydrate metabolism. Aromatase inhibitors, a novel treatment modality for some growth disorders, may significantly influence these risk factors for cardiovascular disease by suppressing o...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Hero M,Ankarberg-Lindgren C,Taskinen MR,Dunkel L

    更新日期:2006-09-01 00:00:00

  • Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling.

    abstract:BACKGROUND:Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response ele...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Rao AS,Kremenevskaja N,Resch J,Brabant G

    更新日期:2005-12-01 00:00:00

  • Effects of deflazacort and cortisone on body growth, thymus weight and gene expression of growth-related proteins in the rat.

    abstract::Deflazacort is an oxazoline derivative of cortisone with presumably less serious side effects, but its effects on growth factors are unknown. The present experiments in Long Evans rats were carried out to investigate how deflazacort administration affected the growing rat, especially in relation to hepatic insulin-lik...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Latta K,Krieg RJ Jr,Chan W,Hisano S,Chan JC

    更新日期:1994-12-01 00:00:00

  • New perspectives for gene therapy in endocrinology.

    abstract::Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Barzon L,Bonaguro R,Palù G,Boscaro M

    更新日期:2000-10-01 00:00:00

  • The octreotide test dose is not a reliable predictor of the subsequent response to somatostatin analogue therapy in patients with acromegaly.

    abstract::In many centres, a test dose (TD) of octreotide is administered before commencing somatostatin analogue therapy (SAT), although the merits of this procedure are uncertain. We have analysed the value of the GH response to a TD in predicting the efficacy of subsequent SAT in 47 patients with acromegaly (25 male, median ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Pokrajac A,Claridge AG,Shakoor SK,Trainer PJ

    更新日期:2006-02-01 00:00:00

  • Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status.

    abstract:OBJECTIVE:Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (P...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Cuestas E,Gaido MI,Capra RH

    更新日期:2015-04-01 00:00:00

  • Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

    abstract:OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

    更新日期:2003-10-01 00:00:00

  • Fluorodesoxyglucose uptake in the remaining adrenal glands during the follow-up of patients with adrenocortical carcinoma: do not consider it as malignancy.

    abstract:OBJECTIVE:To make the specificity of fluorodesoxyglucose ((18)FDG) positron emission tomography (PET) precise, in the follow-up of patients with adrenal cancer. DESIGN:This single centre retrospective study assessed the frequency and outcome of (18)FDG uptake in the remaining adrenal glands after adrenalectomy for adr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Leboulleux S,Deandreis D,Escourrou C,Al Ghuzlan A,Bidault F,Aupérin A,Travagli JP,Lumbroso J,Schlumberger M,Baudin E

    更新日期:2011-01-01 00:00:00

  • Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

    更新日期:2018-10-01 00:00:00

  • 11 beta-Hydroxysteroid dehydrogenase deficit: a rare cause of arterial Hypertension. Diagnosis and therapeutic approach in two young brothers.

    abstract::We report the clinical history and results of endocrine investigations in two brothers born to consanguineous parents, who presented with hypokalemia and arterial hypertension when they were aged 2 and 6 years. The hormonal serum assay results, including extremely low values for aldosterone and plasma renin activity, ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Gourmelen M,Saint-Jacques I,Morineau G,Soliman H,Julien R,Fiet J

    更新日期:1996-08-01 00:00:00

  • Overcoming obstacles: collaboration for change.

    abstract::Effective diabetes care requires a partnership between prepared, proactive practice teams and informed, activated patients. Diabetes education helps to overcome many of the barriers to effective self-management by enabling people with diabetes to make informed decisions about their day-to-day self-care. Both psychosoc...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Funnell MM

    更新日期:2004-10-01 00:00:00

  • Effects of dehydration on endocrine regulation of the electrolyte and fluid balance and atrial natriuretic peptide-binding sites in perinatally malnourished adult male rats.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Sebaai N,Lesage J,Alaoui A,Dupouy JP,Deloof S

    更新日期:2002-12-01 00:00:00

  • CDKN1B V109G polymorphism a new prognostic factor in sporadic medullary thyroid carcinoma.

    abstract:CONTEXT:CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Pasquali D,Circelli L,Faggiano A,Pancione M,Renzullo A,Elisei R,Romei C,Accardo G,Coppola VR,De Palma M,Ferolla P,Grimaldi F,Colao A,Colantuoni V

    更新日期:2011-03-01 00:00:00

  • Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhood.

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    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Vivanco M,Dalle JH,Alberti C,Lescoeur B,Yakouben K,Carel JC,Baruchel A,Léger J

    更新日期:2012-08-01 00:00:00

  • Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?

    abstract::Previous work has examined potential links between the etiology of GH deficiency (GHD) and the baseline characteristics of the patients including biochemical and psychometric parameters. Using an update of the KIMS pharmaco-epidemiological database (Pfizer International Metabolic Database), we addressed the question h...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Brabant G,Poll EM,Jönsson P,Polydorou D,Kreitschmann-Andermahr I

    更新日期:2009-11-01 00:00:00