Abstract:
OBJECTIVE:To control postprandial hyperglycemia in insulin-treated type 2 diabetic patients, prandial therapy with regular human insulin (HI) or fast acting insulin analogs is used. Postprandial hyperglycemia seems to be reduced more effectively with insulin analogs than with normal insulin, but there are no data concerning the effect on lipolysis or pancreatic insulin and proinsulin secretion of normal insulin in comparison to insulin analogs. DESIGN AND METHODS:We included 13 patients with type 2 diabetes mellitus (age 62.2±10.3 years) with preexisting insulin therapy in this crossover, prospective, open-labeled, randomized trial comparing regular HI with insulin aspart (IA) in the setting of a standardized breakfast and a standardized lunch 4 h later. Blood samples for determination of glucose, free fatty acids (FFA), triglycerides, C-peptide, and intact proinsulin were drawn during fasting and every 30 min until 4 h after the second test meal. Statistical analysis was performed with ANOVA for repeated measurements and paired Student's t-test. RESULTS:The mean increase in blood glucose was significantly lower after IA (24.18±16.33 vs 34.92±29.07 mg/dl, P=0.02) compared with HI. Both therapies reduced FFA; however, the mean reduction was significantly higher after IA than after HI (-0.47±0.16 vs -0.35±0.15 μmol/l, P<0.001). The mean increase in intact proinsulin was significantly lower after IA than after HI (10.53±5 vs 15.20±6.83 pmol/l, P<0.001). No differences were observed in the C-peptide levels between the two groups. CONCLUSION:In the setting of two consecutive meals, IA reduces lipolysis and proinsulin secretion more effectively than HI.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Sourij H,Schmoelzer I,de Campo A,Tripolt NJ,Stojakovic T,Scharnagl H,Kettler-Schmut E,Forst T,Wascher TCdoi
10.1530/EJE-11-0061subject
Has Abstractpub_date
2011-08-01 00:00:00pages
269-74issue
2eissn
0804-4643issn
1479-683Xpii
EJE-11-0061journal_volume
165pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality. DESIGN:Cross-sectional study. METHODS:A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this stud...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-13-1025
更新日期:2014-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1430047
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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abstract::Multiple endocrine neoplasia type 1 (MEN 1) is a familial syndrome characterized by parathyroid, enteropancreatic and pituitary tumors. The gene responsible for this syndrome is localized at chromosomal 11q13 region and DNA markers from this region cosegregate with the disease. The recent identification of the MEN1 ge...
journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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