Circadian thyrotropin variations are preserved in normal pregnant women.


:Serum thyrotropin (TSH) concentration circadian rhythm is abolished in many endocrine and non-endocrine diseases. In the present study we have measured serum TSH concentration over 24 h every 2 h in second and third trimester pregnant women. During the 24-h period, serum free thyroxine and free triiodothyronine concentrations did not change significantly. In contrast, serum TSH concentrations demonstrated significant circadian variations both in the second and third trimester pregnant women (p < 0.02 and p < 0.005, respectively). In summary, second and third trimester pregnancy is associated with a normal circadian TSH rhythm.


Eur J Endocrinol


Roti E,Bartalena L,Minelli R,Salvi M,Gardini E,Pistolesi A,Martino E,Braverman LE




Has Abstract


1995-07-01 00:00:00












  • Increased use of antimicrobial agents and hospital admission for infections in patients with primary adrenal insufficiency: a cohort study.

    abstract:BACKGROUND:Previous studies have suggested that infections are an important cause of death in patients with Addison's disease, but epidemiological studies on the frequency of infections in this population are lacking. OBJECTIVE:To assess and compare the incidence risk of infections in patients with primary adrenal ins...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Smans LC,Souverein PC,Leufkens HG,Hoepelman AI,Zelissen PM

    更新日期:2013-03-15 00:00:00

  • Expression of sex hormone-binding globulin mRNA in human ovarian cancers.

    abstract::To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

    更新日期:1995-09-01 00:00:00

  • Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus.

    abstract:OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Rojo-Martínez G,Soriguer FJ,González-Romero S,Tinahones F,Moreno F,de Adana SR,Garriga MJ,Esteva I,García-Arnés J,Gómez-Zumaquero JM,García-Almeida JM

    更新日期:2000-03-01 00:00:00

  • Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?

    abstract::Previous work has examined potential links between the etiology of GH deficiency (GHD) and the baseline characteristics of the patients including biochemical and psychometric parameters. Using an update of the KIMS pharmaco-epidemiological database (Pfizer International Metabolic Database), we addressed the question h...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Brabant G,Poll EM,Jönsson P,Polydorou D,Kreitschmann-Andermahr I

    更新日期:2009-11-01 00:00:00

  • Monocentric study of 112 consecutive patients with childhood onset GH deficiency around and after transition.

    abstract:OBJECTIVES:Our aim was to analyze a large cohort of childhood onset GH deficiency (CO-GHD) adults from a unique adult center, in order to analyze their clinical management and to study the metabolic and bone status in relation to GHD and to the other pituitary deficits, and to evaluate these parameters during the long-...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Courtillot C,Baudoin R,Du Souich T,Saatdjian L,Tejedor I,Pinto G,Léger J,Polak M,Golmard JL,Touraine P,Transition GHD Group.

    更新日期:2013-10-01 00:00:00

  • ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome.

    abstract::Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Tavares C,Melo M,Cameselle-Teijeiro JM,Soares P,Sobrinho-Simões M

    更新日期:2016-04-01 00:00:00

  • Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency.

    abstract:OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Mazziotti G,Porcelli T,Bianchi A,Cimino V,Patelli I,Mejia C,Fusco A,Giampietro A,De Marinis L,Giustina A

    更新日期:2010-07-01 00:00:00

  • A unique exonic splicing mutation in the CYP17A1 gene as the cause for steroid 17{alpha}-hydroxylase deficiency.

    abstract:BACKGROUND:17α-Hydroxylase/17,20-lyase deficiency (17OHD) caused by a mutation in the CYP17A1 gene is characterized by hypertension, hypokalemia, and abnormal development of the genitalia. The majority of CYP17A1 mutations are located in the coding sequence, and several intronic splicing site mutations have been report...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Qiao J,Han B,Liu BL,Liu W,Wu JJ,Pan CM,Jiang H,Gu T,Jiang BR,Zhu H,Lu YL,Wu WL,Chen MD,Song HD

    更新日期:2011-04-01 00:00:00

  • ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms: the two-faced Janus.

    abstract::An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescen...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Giannetta E,Guarnotta V,Altieri B,Sciammarella C,Guadagno E,Malandrino P,Puliani G,Feola T,Isidori AM,Colao AAL,Faggiano A

    更新日期:2020-12-01 00:00:00

  • Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function.

    abstract:OBJECTIVE:Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfun...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Fargnoli JL,Sun Q,Olenczuk D,Qi L,Zhu Y,Hu FB,Mantzoros CS

    更新日期:2010-02-01 00:00:00

  • Epidemiology of hormonal contraceptives-related venous thromboembolism.

    abstract::For many years, it has been well documented that combined hormonal contraceptives increase the risk of venous thromboembolism (VTE). The third-generation pill use (desogestrel or gestodene (GSD)) is associated with an increased VTE risk as compared with second-generation (levonorgestrel) pill use. Other progestins suc...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Hugon-Rodin J,Gompel A,Plu-Bureau G

    更新日期:2014-12-01 00:00:00

  • Anthropometric factors have significant influence on the outcome of the GHRH-arginine test: establishment of normative data for an automated immunoassay specifically measuring 22 kDa human growth hormone.

    abstract:CONTEXT:Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE:To improve the diagnostic accuracy of GH-releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI and sex and established normative data for an automatic immunoassay sp...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

    更新日期:2017-03-01 00:00:00

  • Quantitave and qualitative changes in vascular endothelial growth factor gene expression in glomeruli of patients with type 2 diabetes.

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF 121, VEGF 165 and VEGF 189) and acts via two specific receptors: VEGF-R1 or Flt-1 and VEGF-R2 or KDR. VEGF plays an important role in the pathogenesis of diabetic retinopathy. Th...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Bortoloso E,Del Prete D,Dalla Vestra M,Gambaro G,Saller A,Antonucci F,Baggio B,Anglani F,Fioretto P

    更新日期:2004-06-01 00:00:00

  • Growth hormone deficiency and replacement in hypopituitary patients previously treated for acromegaly or Cushing's disease.

    abstract:OBJECTIVE:To compare baseline characteristics in adult patients with growth hormone (GH) deficiency (GHD) who had previously been treated for Cushing's disease or acromegaly with data from patients with GHD of other aetiologies. To study the effects of GH therapy in those patients who had completed at least 6 months of...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Feldt-Rasmussen U,Abs R,Bengtsson BA,Bennmarker H,Bramnert M,Hernberg-Ståhl E,Monson JP,Westberg B,Wilton P,Wüster C,KIMS International Study Board of KIMS Study Group.

    更新日期:2002-01-01 00:00:00

  • Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging.

    abstract::The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章


    authors: Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni F

    更新日期:1994-11-01 00:00:00

  • Quantification of urinary insulin-like growth factors (IGFs) and IGF binding protein 3 in healthy volunteers before and after stimulation with recombinant human growth hormone.

    abstract::We examined excretion of urinary insulin-like growth factors I and II (IGF-I and IGF-II) and their major binding protein IGFBP-3 in comparison to their respective serum concentration in nine healthy female volunteers (median age 25 years, range 22-27) under baseline conditions and after stimulation with recombinant hu...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章


    authors: Tönshoff B,Blum WF,Vickers M,Kurilenko S,Mehls O,Ritz E

    更新日期:1995-04-01 00:00:00

  • Role of gamma probes in performing minimally invasive parathyroidectomy in patients with primary hyperparathyroidism: optimization of preoperative and intraoperative procedures.

    abstract:OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章


    authors: Rubello D,Piotto A,Casara D,Muzzio PC,Shapiro B,Pelizzo MR

    更新日期:2003-07-01 00:00:00

  • Observing pretibial myxedema in patients with Graves' disease using digital infrared thermal imaging and high-resolution ultrasonography: for better records, early detection, and further investigation.

    abstract:OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

    更新日期:2011-04-01 00:00:00

  • Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study.

    abstract:AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

    更新日期:2015-08-01 00:00:00

  • Sleep-wake and melatonin pattern in craniopharyngioma patients.

    abstract:OBJECTIVE:To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality. DESIGN:Cross-sectional study. METHODS:A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this stud...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Pickering L,Jennum P,Gammeltoft S,Poulsgaard L,Feldt-Rasmussen U,Klose M

    更新日期:2014-06-01 00:00:00

  • Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?

    abstract:BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) have been considered as important mediators of vascular remodeling and plaque instability. The formation of a complex with NGAL and MMP-9 is crucial for atherotic plaque erosion and thrombus formation. In women with poly...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Diamanti-Kandarakis E,Livadas S,Kandarakis SA,Margeli A,Papassotiriou I

    更新日期:2008-04-01 00:00:00

  • Changes in the glycosylation pattern of circulating gonadotropins after acute administration of gonadotropin-releasing hormone in patients with anorexia nervosa.

    abstract::To study the involvement of gonadotropin-releasing hormone (GnRH) in glycosylation of circulating gonadotropin isoforms in anorexia nervosa (AN), 14 amenorrhoic patients with AN, 14 age-matched volunteers in early follicular phase, and five normal-weight re-fed patients with AN were investigated under baseline conditi...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Savastano S,Tommaselli AP,Valentino R,Luciano A,Gigante M,Randazzo G,Contaldo F,Scalfi L,Lombardi G

    更新日期:1998-01-01 00:00:00

  • Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry.

    abstract:CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

    更新日期:2017-05-01 00:00:00

  • Growth modelling of non-functioning pituitary adenomas in patients referred for surgery.

    abstract:OBJECTIVE:Recent observational studies have established progression and recurrence rates of pituitary adenomas. However, it is still unknown how individual pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. The objective of this study was to define a growth model for non-func...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Honegger J,Zimmermann S,Psaras T,Petrick M,Mittelbronn M,Ernemann U,Reincke M,Dietz K

    更新日期:2008-03-01 00:00:00

  • What is the efficacy of switching to weekly pegvisomant in acromegaly patients well controlled on combination therapy?

    abstract:CONTEXT:Although combination therapy of acromegaly with long-acting somatostatin analogs (LA-SSAs) and pegvisomant (PEGV) normalizes insulin-like growth factor-1 (IGF1) levels in the majority of patients, it requires long-term adherence. Switching from combination therapy to monotherapy with weekly PEGV could improve p...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Muhammad A,van der Lely AJ,O'Connor RD,Delhanty PJ,Dal J,Dallenga AH,Feelders RA,Janssen JA,Jorgensen JO,Neggers SJ

    更新日期:2016-05-01 00:00:00

  • Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation.

    abstract::Glucocorticoids (GCs) inhibit bone formation in vivo and inhibit osteoblast proliferation and collagen synthesis in vitro. These effects may be mediated by alterations in the insulin-like growth factor (IGF) system. In the present study of normal human osteoblast-like (HOB) cells, we tested the hypothesis that dexamet...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Chevalley T,Strong DD,Mohan S,Baylink D,Linkhart TA

    更新日期:1996-05-01 00:00:00

  • Hyperandrogenism after menopause.

    abstract::Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evalua...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审


    authors: Markopoulos MC,Kassi E,Alexandraki KI,Mastorakos G,Kaltsas G

    更新日期:2015-02-01 00:00:00

  • Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.

    abstract::The control of prolactin (PRL) secretion by N-methyl-D-aspartate (NMDA) and kainic acid (KA), agonists of NMDA and kainate receptors, and the interactions between NMDA and KA with nitric oxide (NO) were analysed in prepubertal female rats. For this purpose, serum PRL concentrations and hypothalamic and pituitary dopam...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Pinilla L,González D,Tena-Sempere M,Aguilar R,Aguilar E

    更新日期:1996-10-01 00:00:00

  • The octreotide test dose is not a reliable predictor of the subsequent response to somatostatin analogue therapy in patients with acromegaly.

    abstract::In many centres, a test dose (TD) of octreotide is administered before commencing somatostatin analogue therapy (SAT), although the merits of this procedure are uncertain. We have analysed the value of the GH response to a TD in predicting the efficacy of subsequent SAT in 47 patients with acromegaly (25 male, median ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Pokrajac A,Claridge AG,Shakoor SK,Trainer PJ

    更新日期:2006-02-01 00:00:00

  • Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels.

    abstract:OBJECTIVE:Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were t...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章


    authors: Valassi E,Crespo I,Keevil BG,Aulinas A,Urgell E,Santos A,Trainer PJ,Webb SM

    更新日期:2017-02-01 00:00:00