Abstract:
OBJECTIVE:In type I diabetes mellitus, early markers of beta cell damage are needed in order to detect the infraclinical development of the disease. The reg protein may be a good candidate, as the reg gene has been proposed to play a role in the pancreatic beta cell destruction/regeneration process during diabetogenesis in animal models of autoimmune diabetes. The aim of this study was to test the hypothesis whether serum reg protein level could be representative of either the destructive or regenerative process at the beta cell level during the early phases of type I diabetes in humans. DESIGN AND METHODS:We used a highly specific immunoassay to measure serum reg protein level in controls and in three groups of either diabetes prone or diabetic subjects: recently diagnosed diabetic patients, long-standing diabetic patients and islet cell antibody-positive non-diabetic subjects. RESULTS:We found no significant difference between the values observed in these three groups in comparison with control group (90.7+/-18.1ng/ml, 83.1+/-5.6ng/ml, 98.7+/-24.5ng/ml vs 85.5+/- 5.6ng/ml respectively). Moreover, when the insulin reserve was evaluated at 6 months in the recently diagnosed group, serum reg protein levels were not different between patients with or without residual insulin secretion (at onset: 103+/-42 vs 70.3+/-8. 5ng/ml respectively; at 6 months: 79.7+/-25.8ng/ml vs 81.6+/-15ng/ml respectively). In contrast, trypsin levels were significantly lower in every group of diabetic patients. Results were expressed as means +/- S.E.M. and groups compared by Student's t-test (P<0.05). CONCLUSIONS:We conclude that serum reg protein level cannot be used as a marker for the progression of the diabetogenic process in type I diabetes.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Christofilis MA,Carrere J,Atlan-Gepner C,Zevaco-Mattei C,Thivolet C,Baeza N,Figarella C,Vialettes Bdoi
10.1530/eje.0.1410368subject
Has Abstractpub_date
1999-10-01 00:00:00pages
368-73issue
4eissn
0804-4643issn
1479-683Xpii
1410368journal_volume
141pub_type
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journal_title:European journal of endocrinology
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doi:10.1530/eje.0.1340474
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1530/eje.0.1310120
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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abstract::In the last few years, molecular studies on pituitary adenomas have yielded evidence supporting a primary pituitary origin of these tumors. Although the existence of genomic alterations in tumoral cells is strongly suggested by the fact that almost all pituitary adenomas are monoclonal in origin, structural genetic ab...
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abstract::Ahead of Print article withdrawn by publisher. ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0870
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1530/eje.1.02108
更新日期:2006-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.1.02088
更新日期:2006-02-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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journal_title:European journal of endocrinology
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doi:10.1530/eje.0.1460519
更新日期:2002-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0769
更新日期:2010-05-01 00:00:00
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更新日期:2011-09-01 00:00:00
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更新日期:1996-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0085
更新日期:2012-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-06-0699
更新日期:2007-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0843
更新日期:2008-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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更新日期:2006-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1470591
更新日期:2002-11-01 00:00:00