A perspective on stem cells by a clinician.

abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

journal_title：European journal of endocrinology

authors： Gharib H,Papini E,Paschke R

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

journal_title：European journal of endocrinology

authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood. OBJECTIVE:To investigate whether childhood CRT leads to altered sleep-wakefulness organization in adulthood, and to identify the determinants of such alterations. SUBJECTS AND METHODS:Subjective...

journal_title：European journal of endocrinology

authors： Van Someren EJ,Swart-Heikens J,Endert E,Bisschop PH,Swaab DF,Bakker PJ,Romijn JA,Fliers E

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Untreated hypothyroidism is common in iodine-replete areas. Frequent thyroid function testing and use of levothyroxine treatment for subclinical hypothyroidism suggest that the prevalence may have decreased. Therefore, in this study, we examined changes in the prevalence of hypothyroidism in a Norwegian count...

journal_title：European journal of endocrinology

authors： Asvold BO,Vatten LJ,Bjøro T

更新日期：2013-10-01 00:00:00

abstract：:The ob protein, termed leptin, is produced by adipocytes and is thought to act as an afferent satiety signal regulating weight through suppressing appetite and stimulating energy expenditure in humans and/or rodents. Insulin has been found to be a potent stimulator of leptin expression in rodents. It is unclear at pre...

journal_title：European journal of endocrinology

authors： Kiess W,Anil M,Blum WF,Englaro P,Juul A,Attanasio A,Dötsch J,Rascher W

更新日期：1998-05-01 00:00:00

abstract：CONTEXT:Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. OBJECTIVE:To further investigate the endocrine and metabolic responses to extreme HA. METHODS:We studied nine male elite climbers at sea level and at 5200 m after climbing Mt. ...

journal_title：European journal of endocrinology

authors： Benso A,Broglio F,Aimaretti G,Lucatello B,Lanfranco F,Ghigo E,Grottoli S

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

journal_title：European journal of endocrinology

authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

更新日期：2013-04-15 00:00:00

abstract：OBJECTIVE:To investigate the effects of long-term GH in GH-deficient adults, as predicted by IGF-I levels. METHODS:Patients received GH, 5 microg/kg per day for 1 Month and 10 microg/kg per day for another 12-30 Months. Changes in body composition, cardiac structure/function, serum lipids and quality of life were meas...

journal_title：European journal of endocrinology

authors： Ezzat S,Fear S,Gaillard RC,Gayle C,Marcovitz S,Mattioni T,Nussey S,Rees A,Svanberg E

更新日期：2003-12-01 00:00:00

abstract：:The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among ...

journal_title：European journal of endocrinology

authors： Maugendre D,Vérité F,Guilhem I,Genetet B,Allannic H,Delamaire M

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or r...

journal_title：European journal of endocrinology

authors： Manolakis AC,Kapsoritakis AN,Tiaka EK,Sidiropoulos A,Gerovassili A,Satra M,Vamvakopoulou D,Tsiopoulos F,Papanas N,Skoularigis I,Potamianos SP,Vamvakopoulos N

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The first aim of this work was to investigate, under basal conditions in adult male rats, the long-term consequences of perinatal maternal food restriction on the plasma concentrations of vasopressin (VP), aldosterone and atrial natriuretic peptide (ANP) and on plasma renin activity (PRA). Furthermore, under ...

journal_title：European journal of endocrinology

authors： Sebaai N,Lesage J,Alaoui A,Dupouy JP,Deloof S

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia and inappropriately low PTH concentrations. ADH type 1 is caused by activating mutations in the calcium-sensing receptor (CASR), a G-protein-coupled receptor signaling through α11 (Gα11) and αq (Gαq) subunits. Heterozygous activating mutat...

journal_title：European journal of endocrinology

authors： Tenhola S,Voutilainen R,Reyes M,Toiviainen-Salo S,Jüppner H,Mäkitie O

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Thyroid hormone (TH) transporters are expressed in thyrocytes and most play a role in TH release. We asked whether expression of the monocarboxylate transporter 8 (MCT8) and the L-type amino acid transporters LAT2 and LAT4 is changed with thyrocyte dedifferentiation and in hyperfunctioning thyroid tissues. D...

journal_title：European journal of endocrinology

authors： Badziong J,Ting S,Synoracki S,Tiedje V,Brix K,Brabant G,Moeller LC,Schmid KW,Fuhrer D,Zwanziger D

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...

journal_title：European journal of endocrinology

authors： Zaharenko L,Kalnina I,Geldnere K,Konrade I,Grinberga S,Židzik J,Javorský M,Lejnieks A,Nikitina-Zake L,Fridmanis D,Peculis R,Radovica-Spalvina I,Hartmane D,Pugovics O,Tkáč I,Klimčáková L,Pīrāgs V,Klovins J

更新日期：2016-12-01 00:00:00

abstract：Aim:To establish pancreatic alpha-cell mass in lean, non-diabetic humans over the adult lifespan, performed as a follow-up study to beta-cell mass across the adult human lifespan. Methods:We examined human pancreatic autopsy tissue from 66 lean, non-diabetic individuals aged from 30 to 102 years, grouped into deciles:...

journal_title：European journal of endocrinology

authors： Moin ASM,Cory M,Gurlo T,Saisho Y,Rizza RA,Butler PC,Butler AE

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Adult height deficit seen in Turner syndrome (TS) originates, in part, from growth retardation in utero and throughout the first 3 years of life. Earlier diagnosis enables earlier therapeutic intervention, such as with recombinant human GH (r-hGH), which may help to prevent growth retardation. In this open-la...

journal_title：European journal of endocrinology

authors： Linglart A,Cabrol S,Berlier P,Stuckens C,Wagner K,de Kerdanet M,Limoni C,Carel JC,Chaussain JL,French Collaborative Young Turner Study Group.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:The kisspeptin/GPR54 pathway has been proven to be crucial in the process of puberty onset, yet the polymorphisms in the KISS1 gene and their relationships with central precocious puberty (CPP) have not been investigated. This study was performed to reveal the relationship between the gene and the disease. D...

journal_title：European journal of endocrinology

authors： Luan X,Zhou Y,Wang W,Yu H,Li P,Gan X,Wei D,Xiao J

更新日期：2007-07-01 00:00:00

abstract：:In recent years, 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG...

journal_title：European journal of endocrinology

authors： Salvatori M,Biondi B,Rufini V

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...

journal_title：European journal of endocrinology

authors： Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To investigate the frequencies of the major maturity-onset diabetes of the young (MODY) subtypes in a panel of Spanish families and to assess phenotypic differences in patients with the different subtypes of MODY. METHODS:Forty-eight subjects from twenty families with clinical diagnosis of MODY were studied....

journal_title：European journal of endocrinology

authors： Costa A,Bescós M,Velho G,Chêvre J,Vidal J,Sesmilo G,Bellanné-Chantelot C,Froguel P,Casamitjana R,Rivera-Fillat F,Gomis R,Conget I

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Phytosterolaemia (sitosterolaemia) is a rare autosomal recessive condition caused by mutations on the ABCG5 and ABCG8 gut transporter proteins. This leads to accumulation of plant-derived cholesterol-like molecules in blood and tissues. CASE:We describe a family of Bangladesh origin, where three siblings (t...

journal_title：European journal of endocrinology

authors： Mushtaq T,Wales JK,Wright NP

更新日期：2007-08-01 00:00:00

abstract：:Patients with pituitary tumours, ensuing hormonal abnormalities and mass effects are usually followed in multidisciplinary pituitary clinics and can represent a management challenge even during the times of non-pandemic. The COVID-19 pandemic has put on hold routine medical care for hundreds of millions of patients ar...

journal_title：European journal of endocrinology

authors： Fleseriu M,Dekkers OM,Karavitaki N

更新日期：2020-07-01 00:00:00

abstract：:Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or le...

journal_title：European journal of endocrinology

authors： Dumoulin SC,Perret BP,Bennet AP,Caron PJ

更新日期：1995-05-01 00:00:00

abstract：AIM:To describe volumes of orbital fat (FV) and extraocular muscles (MV) in Graves' orbitopathy (GO) as a function of the duration of GO. PATIENTS:i) Cross-sectional survey among 95 consecutive patients with untreated GO who had been referred to the combined thyroid-eye clinics of our university hospital. ii) Longitud...

journal_title：European journal of endocrinology

authors： Potgieser PW,Wiersinga WM,Regensburg NI,Mourits MP

更新日期：2015-08-01 00:00:00

abstract：:The human growth hormone variant (GH-V) gene is expressed during pregnancy in the syncytiotrophoblast and, as shown recently, in the normal human testis. In addition to the classical transcript encoding for the 22 K major form, intron D-retaining processed mRNAs (GH-V2) have also been described in both tissues. In the...

journal_title：European journal of endocrinology

authors： Untergasser G,Hermann M,Rumpold H,Berger P

更新日期：1998-10-01 00:00:00

abstract：:A comparative study of high-dose (HD, carbimazole 60 mg plus thyroxine 100-150 micrograms daily) and titration-dose (TD) regimens of carbimazole was carried out in 70 patients with Graves' disease, the patients being assigned randomly to one or other regimen. The treatment was given for 1 year and follow-up was for 2 ...

journal_title：European journal of endocrinology

authors： Edmonds CJ,Tellez M

更新日期：1994-08-01 00:00:00

abstract：:We investigated the ontogeny of melatonin synthesis during fetal maturation by measuring the melatonin (MLT) and 6-hydroxymelatonin sulfate (MLTS) excretion in the urine of male infants aged 2-7 days and gestational age 26-42 weeks. We found a negative correlation between advancing gestational age and the MLT and MLTS...

journal_title：European journal of endocrinology

authors： Commentz JC,Henke A,Dammann O,Hellwege HH,Willig RP

更新日期：1996-08-01 00:00:00

abstract：:Osteoporosis is being increasingly recognised in paediatric practice as a consequence of several factors. These include the increasing complexity of chronic conditions and the associated treatments managed by paediatricians. In addition, the improved care provided to children with chronic illness has led to many of th...

journal_title：European journal of endocrinology

authors： Shaw NJ

更新日期：2008-12-01 00:00:00

abstract：:To study the involvement of gonadotropin-releasing hormone (GnRH) in glycosylation of circulating gonadotropin isoforms in anorexia nervosa (AN), 14 amenorrhoic patients with AN, 14 age-matched volunteers in early follicular phase, and five normal-weight re-fed patients with AN were investigated under baseline conditi...

journal_title：European journal of endocrinology

authors： Savastano S,Tommaselli AP,Valentino R,Luciano A,Gigante M,Randazzo G,Contaldo F,Scalfi L,Lombardi G

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID). DESIGN:A longitudinal population-based study (DanThyr). METHODS:...

journal_title：European journal of endocrinology

authors： Krejbjerg A,Bjergved L,Pedersen IB,Carlé A,Jørgensen T,Perrild H,Ovesen L,Rasmussen LB,Knudsen N,Laurberg P

更新日期：2014-03-08 00:00:00