当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.

Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.

Abstract：

:Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). The SHBG levels are increased in hyper- and decreased in hypothyroid patients, whereas CBG levels are increased in hypo- and decreased in hyperthyroid patients. The SHBG levels are higher in women than in men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients, SHBG concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In hyperthyroid patients, SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01) during antithyroid treatment. The SHBG and CBG concentrations in treated hypo- and hyperthyroid patients were not significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid status. Corticosteroid-binding globulin is an index of thyroid hormone action at the liver level whose changes are opposite to those of SHBG in hyper- and hypothyroidism.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Dumoulin SC,Perret BP,Bennet AP,Caron PJ

doi

10.1530/eje.0.1320594

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

594-8

issue

5

eissn

0804-4643

issn

1479-683X

journal_volume

132

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Exaggerated blood pressure response to angiotensin II in patients with Cushing's syndrome due to adrenocortical adenoma.

    abstract：:We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1310582

    authors： Yasuda G,Shionoiri H,Umemura S,Takasaki I,Ishii M

    更新日期：1994-12-01 00:00:00

  • Effect of insulin and growth hormone on the synthesis of radiolabelled proteoglycans from cultured human arterial smooth-muscle cells.

    abstract：:The present study focuses on the pathogenesis of increased frequency of large-vessel disease in diabetes. The diabetic arterial wall displays characteristic alterations of the extracellular matrix secreted by arterial smooth-muscle cells. The effects of insulin and growth hormone on the synthesis of sulphate-labelled ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1340326

    authors： Thøgersen VB,Heickendorff L,Ledet T

    更新日期：1996-03-01 00:00:00

  • Associations between subcutaneous fat density and systemic inflammation differ by HIV serostatus and are independent of fat quantity.

    abstract：Objectives:Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV. Design:Cross-sectional analysis of men enrolled in the Multicente...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-19-0296

    authors： Lake JE,Debroy P,Ng D,Erlandson KM,Kingsley LA,Palella FJ,Budoff MJ,Post WS,Brown TT

    更新日期：2019-10-01 00:00:00

  • GEP-NETS update: functional localisation and scintigraphy in neuroendocrine tumours of the gastrointestinal tract and pancreas (GEP-NETs).

    abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-14-0077

    authors： de Herder WW

    更新日期：2014-04-10 00:00:00

  • Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas.

    abstract：OBJECTIVE:To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs). METHODS:Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH). RESULTS:The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1460209

    authors： Garcia JL,Tardio JC,Gutierrez NC,Gonzalez MB,Polo JR,Hernandez JM,Menarguez J

    更新日期：2002-02-01 00:00:00

  • Abiraterone acetate treatment lowers 11-oxygenated androgens.

    abstract：Context:The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required f...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0905

    authors： Wright C,O'Day P,Alyamani M,Sharifi N,Auchus RJ

    更新日期：2020-04-01 00:00:00

  • Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry.

    abstract：CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-16-1064

    authors： Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

    更新日期：2017-05-01 00:00:00

  • Expression of betaglycan in pregnant tIssues throughout gestation.

    abstract：BACKGROUND:Betaglycan is a membrane-anchored proteoglycan involved in mediating the passage of transforming growth factor-beta (TGF-beta), inhibin and activin activities into cells. TGF-beta and inhibin-related proteins are growth factors that are expressed by several tIssues and in pregnancy. They have a function in m...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1490433

    authors： Ciarmela P,Florio P,Toti P,Grasso D,Santopietro R,Tosi P,Petraglia F

    更新日期：2003-11-01 00:00:00

  • An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action.

    abstract：OBJECTIVE:Serum concentrations of soluble tumor necrosis factor-alpha (TNF-alpha) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we provided evidence for the existence of a biologically active form of sTNFR2 produced by alternative splicing (DS-TNFR2). We aimed to evaluate whether this c...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02145

    authors： Fernández-Real JM,Straczkowski M,Lainez B,Chacón MR,Kowalska I,López-Bermejo A,García-España A,Nikolajuk A,Kinalska I,Ricart W

    更新日期：2006-05-01 00:00:00

  • Thyroid function, as assessed by TSH, and future risk of venous thromboembolism: the Tromsø study.

    abstract：OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 1...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0185

    authors： Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

    更新日期：2015-07-01 00:00:00

  • Olfactory receptor 51E1 protein as a potential novel tissue biomarker for small intestine neuroendocrine carcinomas.

    abstract：OBJECTIVE:Late diagnosis hinders proper management of small intestine neuroendocrine carcinoma (SI-NEC) patients. The olfactory receptor, family 51, subfamily E, member 1 (OR51E1) has been reported as a potential novel SI-NEC marker, without protein expression recognition. Thus, we further studied whether the encoded p...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0814

    authors： Cui T,Tsolakis AV,Li SC,Cunningham JL,Lind T,Öberg K,Giandomenico V

    更新日期：2013-01-17 00:00:00

  • Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women.

    abstract：OBJECTIVE:Postmenopausal estradiol (E(2)) levels vary widely between individuals and this variation is an important determinant of diseases such as osteoporosis. It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01973

    authors： Schuit SC,de Jong FH,Stolk L,Koek WN,van Meurs JB,Schoofs MW,Zillikens MC,Hofman A,van Leeuwen JP,Pols HA,Uitterlinden AG

    更新日期：2005-08-01 00:00:00

  • Evidence for co-ordinated changes between vascular endothelial growth factor and nitric oxide synthase III immunoreactivity, the functional status of the thyroid follicles, and the microvascular bed during chronic stimulation by low iodine and propylthiou

    abstract：:Vasoactive and angiogenic factors are involved in the autocrine/paracrine thyroid regulation of microvascular bed during goiter development. In the thyroid of old mice, the presence of slowly functioning ('cold') follicles allowed us to study the microvascular regulation of each follicle in correlation with the immuno...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1420651

    authors： Gérard AC,Xhenseval V,Colin IM,Many MC,Denef JF

    更新日期：2000-06-01 00:00:00

  • Soluble α-klotho: a novel serum biomarker for the activity of GH-producing pituitary adenomas.

    abstract：OBJECTIVE:Klotho is a lifespan-influencing gene expressed mainly in the kidneys. Soluble α-Klotho (αKL) is released into the circulation. In this study, we present baseline αKL serum levels of patients with acromegaly compared with controls with other pituitary adenomas and assess changes following transsphenoidal surg...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-1045

    authors： Neidert MC,Sze L,Zwimpfer C,Sarnthein J,Seifert B,Frei K,Leske H,Rushing EJ,Schmid C,Bernays RL

    更新日期：2013-03-15 00:00:00

  • Serum sex steroids measured in middle-aged European and African-Caribbean men by gas chromatography-mass spectrometry.

    abstract：BACKGROUND:Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-11-0551

    authors： Giton F,Fiet J,Cornu JN,Cussenot O,Bélanger A,Urien S,Oliva A,Blanchet P,Multigner L

    更新日期：2011-12-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Diagnostic and therapeutic approach of tall stature.

    abstract：:Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitut...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-16-1054

    authors： Albuquerque EVA,Scalco RC,Jorge AAL

    更新日期：2017-06-01 00:00:00

  • Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians.

    abstract：OBJECTIVE:Previously, it has been demonstrated that receptor protein tyrosine phosphatase sigma (RPTPsigma) is involved in glucose homeostasis and insulin signaling in several animal models. The aim of this study was to evaluate whether polymorphisms in this gene influence the development of type 2 diabetes (T2D) in hu...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0114

    authors： Långberg EC,Gu HF,Nordman S,Efendic S,Ostenson CG

    更新日期：2007-10-01 00:00:00

  • Continuous s.c. infusion rather than twice-daily injections of IGF-I more effectively increases serum IGF binding protein-3 in female monkeys.

    abstract：OBJECTIVE:In order to better understand how the IGF-I axis is affected by exogenous IGF-I, this study compared the effects of a constant s.c. infusion of IGF-I with that of twice-daily injections of IGF-I in young adult female rhesus monkeys. Clinical studies suggest that circulating concentrations of insulin-like grow...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410303

    authors： Wilson ME,Lackey SL

    更新日期：1999-09-01 00:00:00

  • Transient cold nodule of the thyroid due to localized postpartum thyroiditis.

    abstract：:A 27-year-old woman with no previous personal or family history of thyroid disease was referred to us for the evaluation of thyroid nodule, five months postpartum. Thyroid scintigraphy demonstrated a left cold nodule. Fine needle aspiration cytology of the nodule showed a mixture of colloid, follicular cells and lymph...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380562

    authors： Luboshitzky R,Qupti G,Ishai A,Dharan M

    更新日期：1998-05-01 00:00:00

  • Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant; time for a rethink?

    abstract：OBJECTIVE:To assess the performance of current clinical recommendations for the evaluation of an adrenal incidentaloma. DESIGN AND METHODS LITERATURE REVIEW: Electronic databases (Pubmed, Ovid and citation searches from key articles) from 1980 to 2008 were searched. Eligible studies were those deemed most applicable to...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0234

    authors： Cawood TJ,Hunt PJ,O'Shea D,Cole D,Soule S

    更新日期：2009-10-01 00:00:00

  • Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche.

    abstract：OBJECTIVE:To determine if uterine and ovarian measurements can significantly distinguish between precocious puberty (PP) and premature thelarche (PT) and whether ultrasound has any advantage over the gonadotropin-releasing hormone (GnRH) stimulation test. DESIGN:Prospective. METHODS:One hundred and three girls referr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02151

    authors： de Vries L,Horev G,Schwartz M,Phillip M

    更新日期：2006-06-01 00:00:00

  • Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

    abstract：OBJECTIVE:Free fatty acids (FFAs) deplete the intracellular insulin stores of pancreatic beta-cells. It has been suggested that this results from a lipotoxic dysregulation of both insulin secretion and insulin synthesis. In the present study, this hypothesis was tested within a 12-h time-course by directly relating the...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480481

    authors： Bollheimer LC,Kemptner DM,Kagerbauer SM,Kestler TM,Wrede CE,Buettner R

    更新日期：2003-04-01 00:00:00

  • Effect of activin on production and secretion of prolactin and growth hormone in cultured rat GH3 cells.

    abstract：OBJECTIVE:To evaluate the effect of the growth factor activin A on the secretion of prolactin (PRL) and GH in cultured GH3 cells. METHODS:The concentrations of PRL and GH secreted from GH3 cells cultured in media with and without activin A were measured by RIA, and the expression of PRL mRNA and GH mRNA were analyzed ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1420506

    authors： Tamura N,Irahara M,Kuwahara A,Ushigoe K,Sugino H,Aono T

    更新日期：2000-05-01 00:00:00

  • Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry.

    abstract：:In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be repor...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.1.02326

    authors： Saeger W,Lüdecke DK,Buchfelder M,Fahlbusch R,Quabbe HJ,Petersenn S

    更新日期：2007-02-01 00:00:00

  • A perspective on stem cells by a clinician.

    abstract：:Stem cell terminology has entered the lexicon of medical practitioners even though the application of harvesting stem cells to treat diseases other than haematological disorders is not yet a reality in clinical practice. All branches of medicine will be affected by the new technology, more so those related to regenera...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.151u003

    authors： Hughes IA

    更新日期：2004-11-01 00:00:00

  • Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review.

    abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-12-0167

    authors： Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

    更新日期：2012-07-01 00:00:00

  • Trans-sphenoidal surgery for microprolactinoma: an acceptable alternative to dopamine agonists?

    abstract：AIMS:Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN:A retrospective review...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1400043

    authors： Turner HE,Adams CB,Wass JA

    更新日期：1999-01-01 00:00:00

  • Sympatho-vagal control of heart rate variability in patients treated with suppressive doses of L-thyroxine for thyroid cancer.

    abstract：OBJECTIVE:This study aimed to analyze the autonomic control of heart rate variability (HRV) in subjects receiving chronic l-thyroxine (l-T4) treatment after total thyroidectomy and (131)I therapy for differentiated thyroid carcinoma. METHODS:Blood pressure (BP) and sympatho-vagal activity (evaluated by power spectral ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01918

    authors： Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

    更新日期：2005-06-01 00:00:00

  • Variable biological activity of thyroid-stimulating hormone.

    abstract：:Thyroid-stimulating hormone (TSH), like the other pituitary glycoprotein hormones, is produced and secreted as a mixture of isoforms, the majority of which represent differences in oligosaccharide structure and possess different bioactivity. When samples are quantified simultaneously by immunometric assay and bioassay...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1310331

    authors： Beck-Peccoz P,Persani L

    更新日期：1994-10-01 00:00:00

  • Identification and characterization of a corticotrophin-releasing hormone receptor in human placenta.

    abstract：:Corticotrophin-releasing hormone (CRH) causes vasodilatation in the human fetal-placental circulation and has paracrine actions in placental tissue, suggesting that CRH receptors may be present in the human placenta. We have now identified and characterized placental CRH binding sites and compared them to those descri...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1330591

    authors： Clifton VL,Owens PC,Robinson PJ,Smith R

    更新日期：1995-11-01 00:00:00