Abiraterone acetate treatment lowers 11-oxygenated androgens.

abstract：CONTEXT:McCune-Albright syndrome (MAS) is a disorder caused by a post-zygotic gain-of-function mutation in the gene encoding the Gs-alpha protein. Sexual precocity, common in girls, has been reported in only 15% of boys, and little is known on the long-term evolution of MAS in males. OBJECTIVE:In a boy with MAS, we st...

journal_title：European journal of endocrinology

authors： De Luca F,Mitchell V,Wasniewska M,Arrigo T,Messina MF,Valenzise M,de Sanctis L,Lahlou N

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

journal_title：European journal of endocrinology

authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIM:Our previous studies showed that administration of dexamethasone plus food increased serum leptin levels 100% more than dexamethasone alone. We hypothesized that this increase in leptin from the meal could result directly from the provision of fuel metabolites rather than from the meal-induced rise in in...

journal_title：European journal of endocrinology

authors： Garcia-Lorda P,Nash W,Roche A,Pi-Sunyer FX,Laferrere B

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Adrenocorticotropic hormone (ACTH) is the primary secretagogue stimulating secretion of adrenal androgens (AA). Yet, genetic and environmental factors are assumed to play a determining role in the regulation of their biosynthesis and thus might explain the high variability of AA levels. Here we investigate th...

journal_title：European journal of endocrinology

authors： Reisch N,Slawik M,Zwermann O,Beuschlein F,Reincke M

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：Background:Autosomal dominant neurohypophyseal diabetes insipidus (adNDI) is caused by arginine vasopressin (AVP) deficiency resulting from mutations in the AVP-NPII gene encoding the AVP preprohormone. Aim:To describe the clinical and molecular features of Italian unrelated families with central diabetes insipidus. ...

journal_title：European journal of endocrinology

authors： Patti G,Scianguetta S,Roberti D,Di Mascio A,Balsamo A,Brugnara M,Cappa M,Casale M,Cavarzere P,Cipriani S,Corbetta S,Gaudino R,Iughetti L,Martini L,Napoli F,Peri A,Salerno MC,Salerno R,Passeri E,Maghnie M,Perrotta

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The somatic point mutation in the BRAF gene, which results in a valine-to-glutamate substitution at residue 600 (BRAF(V600E)), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence is varyingly reported in different studies, and its expression in the follicular variant PTC is cont...

journal_title：European journal of endocrinology

authors： Sapio MR,Posca D,Troncone G,Pettinato G,Palombini L,Rossi G,Fenzi G,Vitale M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The orexigenic and adipogenic peptide hormone ghrelin is predominantly produced and secreted by the stomach and seems to transduce changes in food intake to specific neuronal circuits in the brain. The activity of ghrelin also includes stimulatory effects on the corticotropic system. However, little is known ...

journal_title：European journal of endocrinology

authors： Otto B,Tschöp M,Heldwein W,Pfeiffer AF,Diederich S

更新日期：2004-07-01 00:00:00

abstract：:Osteopetrosis is a rare metabolic bone disease characterized by a generalized increase in skeletal mass. It is inherited in a number of mammalian species, including man, and results from a congenital defect in the development or function of the osteoclasts. The consequent impairment of bone resorption prevents formati...

journal_title：European journal of endocrinology

authors： Felix R,Hofstetter W,Cecchini MG

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of ind...

journal_title：European journal of endocrinology

authors： Meyer G,Mayer M,Mondorf A,Fluegel AK,Herrmann E,Bojunga J

更新日期：2019-11-01 00:00:00

abstract：:A large majority of the currently diagnosed patients with hyperparathyroidism (PHPT) are mild or asymptomatic, mainly women after menopause. Following the debate held at the 16th European Congress of Endocrinology in Wroclaw (Poland) from May 3-7, 2014, arguments are here presented by a surgeon and a medical practitio...

journal_title：European journal of endocrinology

authors： Niederle B,Wémeau JL

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

journal_title：European journal of endocrinology

authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells. The aim of the study was to assess Sertoli cell function in subjects with AZFc deletions. DESIGN:Case-cont...

journal_title：European journal of endocrinology

authors： Foresta C,Bettella A,Moro E,Rossato M,Merico M,Garolla A,Ferlin A

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. DESIGN:Observati...

journal_title：European journal of endocrinology

authors： Voorhoeve PG,van Rossum EF,Te Velde SJ,Koper JW,Kemper HC,Lamberts SW,de Waal HA

更新日期：2006-03-01 00:00:00

abstract：CONTEXT:Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE:To improve the diagnostic accuracy of GH-releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI and sex and established normative data for an automatic immunoassay sp...

journal_title：European journal of endocrinology

authors： Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

更新日期：2017-03-01 00:00:00

abstract：:Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantis...

journal_title：European journal of endocrinology

authors： Beckers A,Daly AF

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00

abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...

journal_title：European journal of endocrinology

authors： de Herder WW

更新日期：2014-04-10 00:00:00

abstract：OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...

journal_title：European journal of endocrinology

authors： Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

更新日期：2001-02-01 00:00:00

abstract：:Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

journal_title：European journal of endocrinology

authors： Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

更新日期：2021-01-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is a familial syndrome characterized by parathyroid, enteropancreatic and pituitary tumors. The gene responsible for this syndrome is localized at chromosomal 11q13 region and DNA markers from this region cosegregate with the disease. The recent identification of the MEN1 ge...

journal_title：European journal of endocrinology

authors： Morelli A,Falchetti A,Martineti V,Becherini L,Mark M,Friedman E,Brandi ML

更新日期：2000-02-01 00:00:00

abstract：:The aim of this study was to assess the usefulness of ketoconazole as a therapeutic alternative to polycystic ovary syndrome. The study group comprised 37 women with signs of hyperandrogenism (hirsutism, acne) and oligomenorrhea. A low dose (400 mg/day) of ketoconazole was tested in a 9-month prospective clinical stud...

journal_title：European journal of endocrinology

authors： Vidal-Puig AJ,Muñoz-Torres M,Jódar-Gimeno E,García-Calvente CJ,Lardelli P,Ruiz-Requena ME,Escobar-Jiménez F

更新日期：1994-04-01 00:00:00

abstract：:Kidney dysfunction has been observed in aged humans and rats, the primary cause of which may reside in the kidney itself or in the hypothalamus. The latter possibility is suggested by the increased release of AVP in response to salt infusion in humans. The effect of age on the relationship between plasma osmolality an...

journal_title：European journal of endocrinology

authors： Terwel D,Jolles J

更新日期：1994-07-01 00:00:00

abstract：:We recently found evidence indicating that the source of elevated serum insulin-like growth factor binding protein (IGFBP)-2 in leukemia was the leukemic T-cells. Here we report that locally produced IGF-II affects IGFBP-2 expression and growth of leukemic cells through the IGF type I receptor. We measured IGFBP-2, -4...

journal_title：European journal of endocrinology

authors： Elmlinger MW,Sanatani MS,Bell M,Dannecker GE,Ranke MB

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...

journal_title：European journal of endocrinology

authors： Wunder DM,Yared M,Bersinger NA,Widmer D,Kretschmer R,Birkhäuser MH

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Subclinical hypothyroidism occurs in a number of children with Down's syndrome (DS). The reason for the mildly elevated plasma thyrotropin (TSH) concentrations is not known. The present study investigated whether decreased TSH bioactivity plays a role in this phenomenon. DESIGN:A retrospective study of plasm...

journal_title：European journal of endocrinology

authors： Konings CH,van Trotsenburg AS,Ris-Stalpers C,Vulsma T,Wiedijk BM,de Vijlder JJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:An increased tendency towards thromboembolic events is observed in patients with Cushing's syndrome. There are much fewer publications available about thromboembolic complications in patients with subclinical Cushing's syndrome (SCS). Therefore, a question arises whether hemostatic disturbances appear in this...

journal_title：European journal of endocrinology

authors： Swiatkowska-Stodulska R,Kaniuka-Jakubowska S,Wisniewski P,Skibowska-Bielinska A,Sworczak K

更新日期：2011-12-01 00:00:00

abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

journal_title：European journal of endocrinology

authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

更新日期：1994-08-01 00:00:00

abstract：:The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...

journal_title：European journal of endocrinology

authors： Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Previous evidence has suggested that a low sex hormone-binding globulin (SHBG) concentration is associated with insulin-resistance and a low adiponectin concentration. We investigated the association between SHBG and the risk of hyperglycemia in each sex and we determined potential interactions between SHBG a...

journal_title：European journal of endocrinology

authors： Bonnet F,Balkau B,Malécot JM,Picard P,Lange C,Fumeron F,Aubert R,Raverot V,Déchaud H,Tichet J,Lecomte P,Pugeat M,DESIR Study Group.

更新日期：2009-07-01 00:00:00