当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > The relationship between plasma osmolality and plasma vasopressin concentration is altered in old male Lewis rats.

The relationship between plasma osmolality and plasma vasopressin concentration is altered in old male Lewis rats.

Abstract：

:Kidney dysfunction has been observed in aged humans and rats, the primary cause of which may reside in the kidney itself or in the hypothalamus. The latter possibility is suggested by the increased release of AVP in response to salt infusion in humans. The effect of age on the relationship between plasma osmolality and plasma AVP concentration has never been verified in an animal model. Therefore, in the present study, 9% salt solution was infused into adult and aged Lewis rats, and plasma AVP concentration and osmolality were measured. Basal plasma AVP concentration, osmolality and total water intake were not altered in aged Lewis rats as compared with adult animals, indicating the absence of overt disturbances in water homeostasis. Infusion of 9% salt solution resulted in a linear increase in plasma osmolality in both adult and aged rats. Plasma osmolality increased more with time in aged animals than in adult animals, suggesting an age-related difference in kidney function during salt infusion. Plasma AVP concentration increased 50% less with osmolality at relatively low osmolalities, but not at relatively high osmolalities. The altered relationship between plasma osmolality and plasma AVP concentration in rats with age may be related to changes in neurons monitoring osmolality or to changes in baroreflex regulation. The data suggest that reduced kidney function with age does not result from an altered relationship between plasma osmolality and plasma AVP concentration.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Terwel D,Jolles J

doi

10.1530/eje.0.1310086

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

86-90

issue

1

eissn

0804-4643

issn

1479-683X

journal_volume

131

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • CDKN1B V109G polymorphism a new prognostic factor in sporadic medullary thyroid carcinoma.

    abstract：CONTEXT:CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0929

    authors： Pasquali D,Circelli L,Faggiano A,Pancione M,Renzullo A,Elisei R,Romei C,Accardo G,Coppola VR,De Palma M,Ferolla P,Grimaldi F,Colao A,Colantuoni V

    更新日期：2011-03-01 00:00:00

  • 11 beta-Hydroxysteroid dehydrogenase deficit: a rare cause of arterial Hypertension. Diagnosis and therapeutic approach in two young brothers.

    abstract：:We report the clinical history and results of endocrine investigations in two brothers born to consanguineous parents, who presented with hypokalemia and arterial hypertension when they were aged 2 and 6 years. The hormonal serum assay results, including extremely low values for aldosterone and plasma renin activity, ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1350238

    authors： Gourmelen M,Saint-Jacques I,Morineau G,Soliman H,Julien R,Fiet J

    更新日期：1996-08-01 00:00:00

  • Macroprolactinaemia: a biological diagnostic strategy from the study of 222 patients.

    abstract：OBJECTIVES:Gel filtration chromatography (GFC), the gold standard for macroprolactinaemia (MPRL) diagnosis, is a slow, costly and labour-intensive method. To limit the number of GFC required, we evaluated two screening tests for MPRL: prolactin (PRL) recovery after polyethylene glycol (PEG) precipitation and PRL concen...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-14-1073

    authors： Parlant-Pinet L,Harthé C,Roucher F,Morel Y,Borson-Chazot F,Raverot G,Raverot V

    更新日期：2015-06-01 00:00:00

  • Abnormal carotid arterial wall dynamics in symptom-free hypopituitary adults.

    abstract：OBJECTIVE:Although vascular mortality is increased in hypopituitary adults on routine replacement, there are limited data on the atherosclerotic process during life in these patients. Measurement of arterial stiffness may provide an index of early vascular changes that predispose to the development of major vascular ac...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360157

    authors： Markussis V,Beshyah SA,Fisher C,Parker KH,Nicolaides AN,Johnston DG

    更新日期：1997-02-01 00:00:00

  • The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients.

    abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0775

    authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

    更新日期：2013-04-15 00:00:00

  • ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome.

    abstract：:Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-15-0605

    authors： Tavares C,Melo M,Cameselle-Teijeiro JM,Soares P,Sobrinho-Simões M

    更新日期：2016-04-01 00:00:00

  • Transition in endocrinology: induction of puberty.

    abstract：:Puberty is the period during which we attain adult secondary sexual characteristics and reproductive capability. Its onset depends upon reactivation of pulsative GNRH, secretion from its relative quiescence during childhood, on the background of intact potential for pituitary-gonadal function. This review is intended:...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0894

    authors： Dunkel L,Quinton R

    更新日期：2014-06-01 00:00:00

  • Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhood.

    abstract：BACKGROUND:The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE:The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematolog...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0073

    authors： Vivanco M,Dalle JH,Alberti C,Lescoeur B,Yakouben K,Carel JC,Baruchel A,Léger J

    更新日期：2012-08-01 00:00:00

  • Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndrome.

    abstract：OBJECTIVE:While anti-pituitary antibodies (APAs) were detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far. DESIGN:The aim of this study ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0647

    authors： De Bellis A,Kelestimur F,Sinisi AA,Ruocco G,Tirelli G,Battaglia M,Bellastella G,Conzo G,Tanriverdi F,Unluhizarci K,Bizzarro A,Bellastella A

    更新日期：2008-02-01 00:00:00

  • Dose-dependent effects of recombinant human growth hormone on biochemical markers of bone and collagen metabolism in adult growth hormone deficiency.

    abstract：:Administration of growth hormone (GH) to patients with growth hormone deficiency (GHD) has beneficial effects, but so far has been employed only empirically. We have, therefore, investigated the dose-dependent effect of GH on target tissue by studying biochemical markers of bone and collagen turnover in GHD. Then pati...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1350666

    authors： Bollerslev J,Møller J,Thomas S,Djøseland O,Christiansen JS

    更新日期：1996-12-01 00:00:00

  • Thyroid nodules: a review of current guidelines, practices, and prospects.

    abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-08-0135

    authors： Gharib H,Papini E,Paschke R

    更新日期：2008-11-01 00:00:00

  • Catecholamine production in patients with gastroenteropancreatic neuroendocrine tumors.

    abstract：OBJECTIVE:Amine precursor uptake and decarboxylation is a classical feature of gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Production of catecholamines was studied in GEP NET and non-NET patients. DESIGN:A cross-sectional study was undertaken. METHODS:We studied catecholamine and metabolite secretion in...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1400434

    authors： Ciofu A,Baudin E,Chanson P,Cailleux AF,Comoy E,Sabourin JC,Ducreux M,Schaison G,Schlumberger M

    更新日期：1999-05-01 00:00:00

  • Acute effects of hydrocortisone on the metabolic response to a glucose load: increase in the first-phase insulin secretion.

    abstract：BACKGROUND AND AIM:Several basic science studies support the existence of non-genomic glucocorticoid signaling in pancreas, liver, and adipocytes, but its clinical relevance has not yet been elucidated. This study aimed at investigating the rapid effects of hydrocortisone on the human metabolic response to glucose. SU...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-10-0282

    authors： Vila G,Krebs M,Riedl M,Baumgartner-Parzer SM,Clodi M,Maier C,Pacini G,Luger A

    更新日期：2010-08-01 00:00:00

  • IGF receptor gene variants in normal adolescents: effect on stature.

    abstract：OBJECTIVE:IGF1 is essential for human growth and mediates its effects through the type 1 IGF receptor (IGF1R). Our objective was to determine the frequency of certain previously reported IGF1R gene variants in the normal population and their effect on stature. DESIGN:A cross-sectional study was conducted in a populati...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0565

    authors： Kansra AR,Dolan LM,Martin LJ,Deka R,Chernausek SD

    更新日期：2012-12-01 00:00:00

  • Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation.

    abstract：OBJECTIVE:The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS:Study cohort included 8...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0195

    authors： Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

    更新日期：2007-09-01 00:00:00

  • Validation of a next-generation sequencing (NGS) panel to improve the diagnosis of X-linked hypophosphataemia (XLH) and other genetic disorders of renal phosphate wasting.

    abstract：Background:Hypophosphataemic rickets (HR) comprise a clinically and genetically heterogeneous group of conditions, defined by renal-tubular phosphate wasting and consecutive loss of bone mineralisation. X-linked hypophosphataemia (XLH) is the most common form, caused by inactivating dominant mutations in PHEX, a gene e...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-0275

    authors： Thiele S,Werner R,Stubbe A,Hiort O,Hoeppner W

    更新日期：2020-11-01 00:00:00

  • Fluorodesoxyglucose uptake in the remaining adrenal glands during the follow-up of patients with adrenocortical carcinoma: do not consider it as malignancy.

    abstract：OBJECTIVE:To make the specificity of fluorodesoxyglucose ((18)FDG) positron emission tomography (PET) precise, in the follow-up of patients with adrenal cancer. DESIGN:This single centre retrospective study assessed the frequency and outcome of (18)FDG uptake in the remaining adrenal glands after adrenalectomy for adr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0666

    authors： Leboulleux S,Deandreis D,Escourrou C,Al Ghuzlan A,Bidault F,Aupérin A,Travagli JP,Lumbroso J,Schlumberger M,Baudin E

    更新日期：2011-01-01 00:00:00

  • The growth response to GH treatment is greater in patients with SHOX enhancer deletions compared to SHOX defects.

    abstract：OBJECTIVE:Short stature caused by point mutations or deletions of the short stature homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with a SHOX enhancer deletion (SED) have a similar phenotype, but their response to GH is unknown. It is uncertain if duplication...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-15-0451

    authors： Donze SH,Meijer CR,Kant SG,Zandwijken GR,van der Hout AH,van Spaendonk RM,van den Ouweland AM,Wit JM,Losekoot M,Oostdijk W

    更新日期：2015-11-01 00:00:00

  • Osteogenesis imperfecta: an update on clinical features and therapies.

    abstract：:Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by bone fragility and skeletal deformities. While the majority of cases are associated with pathogenic variants in COL1A1 and COL1A2, the genes encoding type I collagen, up to 25% of cases are associated with other genes that function within...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-20-0299

    authors： Marom R,Rabenhorst BM,Morello R

    更新日期：2020-10-01 00:00:00

  • A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment.

    abstract：OBJECTIVE:For patients who remain hypothyroid despite the administration of what would seem adequate doses of levothyroxine (L-T4), the underlying cause can be difficult to determine. The possibility of a biological cause should first be explored; however, in the majority of cases, poor adherence to medication is likel...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-1035

    authors： Walker JN,Shillo P,Ibbotson V,Vincent A,Karavitaki N,Weetman AP,Wass JA,Allahabadia A

    更新日期：2013-05-10 00:00:00

  • In Reply: The MELAS phenotype may not only be determined by heteroplasmy of causative mtDNA variants.

    abstract：:none. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-1426

    authors： Chae HW,Lee YM

    更新日期：2021-01-01 00:00:00

  • Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis.

    abstract：Introduction:Pathologically high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly are associated with arthropathy. Several studies highlight the potential role of the GH/IGF-1 axis in primary osteoarthritis (OA). We aimed to disentangle the role of IGF-1 levels in primary ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-0904

    authors： Pelsma ICM,Claessen KMJA,Slagboom PE,van Heemst D,Pereira AM,Kroon HM,Ramos YFM,Kloppenburg M,Biermasz NR,Meulenbelt IM

    更新日期：2021-01-01 00:00:00

  • Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity?

    abstract：:We report on a 15-year-old girl who had presented with acute onset central diabetes insipidus at the age of 8 years; this was followed by growth failure due to acquired growth hormone deficiency. Initial magnetic resonance imaging showed a uniformly enlarged pituitary stalk and absence of posterior pituitary hyperinte...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1390635

    authors： Maghnie M,Genovese E,Sommaruga MG,Aricò M,Locatelli D,Arbustini E,Pezzotta S,Severi F

    更新日期：1998-12-01 00:00:00

  • Therapy of endocrine disease: the challenges in managing giant prolactinomas.

    abstract：:Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40  mm or more, signi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-14-0013

    authors： Maiter D,Delgrange E

    更新日期：2014-06-01 00:00:00

  • A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly.

    abstract：OBJECTIVE:ATL1103 is a second-generation antisense oligomer targeting the human growth hormone (GH) receptor. This phase 2 randomised, open-label, parallel-group study assessed the potential of ATL1103 as a treatment for acromegaly. DESIGN:Twenty-six patients with active acromegaly (IGF-I >130% upper limit of normal) ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-18-0138

    authors： Trainer PJ,Newell-Price JDC,Ayuk J,Aylwin SJB,Rees A,Drake W,Chanson P,Brue T,Webb SM,Fajardo C,Aller J,McCormack AI,Torpy DJ,Tachas G,Atley L,Ryder D,Bidlingmaier M

    更新日期：2018-08-01 00:00:00

  • Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men.

    abstract：:We here investigate the potential rescue of the relative hyposomatotropism of aging and obesity by 3-day pulsatile GHRH infusions (i.v. bolus 0.33 microg/kg every 90 min) in 19 healthy men of varying ages (18 to 66 years) and body compositions (12 to 37% total body fat). Baseline (control) and GHRH-driven pulsatile GH...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1390059

    authors： Iranmanesh A,South S,Liem AY,Clemmons D,Thorner MO,Weltman A,Veldhuis JD

    更新日期：1998-07-01 00:00:00

  • Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes.

    abstract：OBJECTIVE:Glucocorticoid excess leads to insulin resistance. This study explores the effects of glucocorticoids on the glucose transport system and insulin signalling in rat adipocytes. The interaction between glucocorticoids and high levels of insulin and glucose is also addressed. DESIGN AND METHODS:Isolated rat adi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1460419

    authors： Burén J,Liu HX,Jensen J,Eriksson JW

    更新日期：2002-03-01 00:00:00

  • Hyperandrogenism after menopause.

    abstract：:Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evalua...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-14-0468

    authors： Markopoulos MC,Kassi E,Alexandraki KI,Mastorakos G,Kaltsas G

    更新日期：2015-02-01 00:00:00

  • The estimation of selected endogenous anticoagulation system parameters in patients with subclinical Cushing's syndrome.

    abstract：OBJECTIVE:An increased tendency towards thromboembolic events is observed in patients with Cushing's syndrome. There are much fewer publications available about thromboembolic complications in patients with subclinical Cushing's syndrome (SCS). Therefore, a question arises whether hemostatic disturbances appear in this...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0535

    authors： Swiatkowska-Stodulska R,Kaniuka-Jakubowska S,Wisniewski P,Skibowska-Bielinska A,Sworczak K

    更新日期：2011-12-01 00:00:00

  • Molecular defects of the CYP21 gene in Spanish girls with isolated precocious pubarche.

    abstract：OBJECTIVE:To determine the frequency of mutant alleles in the CYP21 gene in Spanish girls presenting with precocious pubarche (PP) and to assess the relationships between genotype and endocrine-metabolic variables. DESIGN:Fifty-three unrelated girls with a history of PP (14 prepubertal, 8 pubertal and 31 postmenarchea...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470485

    authors： Potau N,Riqué S,Eduardo I,Marcos V,Ibañez L

    更新日期：2002-10-01 00:00:00