ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome.

abstract：:We report on a 15-year-old girl who had presented with acute onset central diabetes insipidus at the age of 8 years; this was followed by growth failure due to acquired growth hormone deficiency. Initial magnetic resonance imaging showed a uniformly enlarged pituitary stalk and absence of posterior pituitary hyperinte...

journal_title：European journal of endocrinology

authors： Maghnie M,Genovese E,Sommaruga MG,Aricò M,Locatelli D,Arbustini E,Pezzotta S,Severi F

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...

journal_title：European journal of endocrinology

authors： Zaharenko L,Kalnina I,Geldnere K,Konrade I,Grinberga S,Židzik J,Javorský M,Lejnieks A,Nikitina-Zake L,Fridmanis D,Peculis R,Radovica-Spalvina I,Hartmane D,Pugovics O,Tkáč I,Klimčáková L,Pīrāgs V,Klovins J

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term effects of antipsychotic (AP) treatment and AP-induced hyperprolactinemia on bone mineral density (BMD) and body composition in male adolescents with autism spectrum disorders (ASDs) and/or disruptive behavior disorder (DBD). DESIGN:Physically healthy 10- to 20-year-old boys with...

journal_title：European journal of endocrinology

authors： Roke Y,van Harten PN,Buitelaar JK,Tenback DE,Quekel LG,de Rijke YB,Boot AM

更新日期：2012-12-01 00:00:00

abstract：AIMS:Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN:A retrospective review...

journal_title：European journal of endocrinology

authors： Turner HE,Adams CB,Wass JA

更新日期：1999-01-01 00:00:00

abstract：:Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet's effects in patien...

journal_title：European journal of endocrinology

authors： Kawata T,Imanishi Y,Kobayashi K,Kenko T,Wada M,Ishimura E,Miki T,Nagano N,Inaba M,Arnold A,Nishizawa Y

更新日期：2005-10-01 00:00:00

abstract：DESIGN:In order to characterize whether different degrees of adipose tissue storage may be associated with markers of early atherosclerosis, we evaluated oxidant-antioxidant status and inflammatory markers and determined carotid intima-media thickness (cIMT) in healthy constitutional lean and obese pre-pubertal childre...

journal_title：European journal of endocrinology

authors： Giannini C,de Giorgis T,Scarinci A,Cataldo I,Marcovecchio ML,Chiarelli F,Mohn A

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Hyperprolactinemia has been reported to be associated with abnormalities of carbohydrate metabolism. The aim of this study was to evaluate the effects of hyperprolactinemia and bromocriptine (Brc) treatment on endothelial function, insulin sensitivity and inflammatory markers in pre-menopausal women. METHOD...

journal_title：European journal of endocrinology

authors： Yavuz D,Deyneli O,Akpinar I,Yildiz E,Gözü H,Sezgin O,Haklar G,Akalin S

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

journal_title：European journal of endocrinology

authors： Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Cases of men with estrogen resistance and aromatase deficiency have highlighted the effects of estrogens on bone metabolism, the cardiovascular system and biochemical variables of the metabolic syndrome. In eugonadal men, administration of an aromatase inhibitor induces a substantial elevation of LH and testo...

journal_title：European journal of endocrinology

authors： Bunck MC,Toorians AW,Lips P,Gooren LJ

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether patients with Addison's disease and polyendocrine syndromes have undiagnosed autoimmune polyendocrine syndrome type I (APS I). MATERIALS AND METHODS:Forty patients with clinical manifestations resembling APS I and with autoantibodies typical of this condition were screened for Norwegia...

journal_title：European journal of endocrinology

authors： Bøe AS,Knappskog PM,Myhre AG,Sørheim JI,Husebye ES

更新日期：2002-04-01 00:00:00

abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

journal_title：European journal of endocrinology

authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

更新日期：1994-08-01 00:00:00

abstract：:In recent years, 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG...

journal_title：European journal of endocrinology

authors： Salvatori M,Biondi B,Rufini V

更新日期：2015-09-01 00:00:00

abstract：:Glycoprotein hormone alpha-subunit (alpha SU) is a recognized product of clinically non-functioning, glycoprotein hormone-secreting and somatotroph adenomas but has not been studied systematically in corticotroph tumours. We have performed immunohistochemistry for alpha SU in a consecutive series of four corticotroph ...

journal_title：European journal of endocrinology

authors： Desai B,Burrin JM,Nott CA,Geddes JF,Lamb EJ,Aylwin SJ,Wood DF,Thakkar C,Monson JP

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. DESIGN:Population based, cross-sectional study. METHODS:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical his...

journal_title：European journal of endocrinology

authors： Kamycheva E,Sundsfjord J,Jorde R

更新日期：2004-08-01 00:00:00

abstract：:Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical s...

journal_title：European journal of endocrinology

authors： Støving RK

更新日期：2019-01-01 00:00:00

abstract：:Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), arising from gain-of-function mutations in Gαs, and cutaneous skeletal hypophosphatemia syndrome (CSHS), arising from gain-of-function mutations in the Ras/MAPK pathway, are strikingly complex, mosaic diseases with overlapping phenotypes. Both disorders are defined ...

journal_title：European journal of endocrinology

authors： de Castro LF,Ovejero D,Boyce AM

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated a high prevalence of thyroperoxidase antibodies (TPOAb) and autoimmune hypothyroidism in breast cancer (BC). These studies have been performed in BC patients generally 20-30 days after mastectomy. It is known that stress may have an influence on the immune system and a rela...

journal_title：European journal of endocrinology

authors： Giustarini E,Pinchera A,Fierabracci P,Roncella M,Fustaino L,Mammoli C,Giani C

更新日期：2006-05-01 00:00:00

abstract：:Phaeochromocytoma is a rare, usually benign, tumour predominantly managed by endocrinologists. Over the last decade, major advances have been made in understanding the molecular genetic basis of adrenal and extra-adrenal phaeochromocytoma (also referred to as adrenal phaeochromocytoma (aPCA) and extra-adrenal function...

journal_title：European journal of endocrinology

authors： Jafri M,Maher ER

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:The insulin-resistant state of the polycystic ovary syndrome (PCOS) was found to be associated with a decreased glucose transporter GLUT4 expression in the insulin target tissues. This study was performed to explore whether the well-known clinical, hormonal and metabolic efficacy of metformin or rosiglitazone...

journal_title：European journal of endocrinology

authors： Jensterle M,Janez A,Mlinar B,Marc J,Prezelj J,Pfeifer M

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Activin is a growth and differentiation factor of many cell types, and has recently been implicated in inflammatory processes. Clinical data linking activin and its binding protein, follistatin (FS), are lacking. We measured serum levels of activin and FS in patients diagnosed with septicemia. PATIENTS AND M...

journal_title：European journal of endocrinology

authors： Michel U,Ebert S,Phillips D,Nau R

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

journal_title：European journal of endocrinology

authors： Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Thyroidal production of triiodothyronine (T(3)) is absent in patients who have undergone total thyroidectomy. Therefore, relative T(3) deficiency may occur during postoperative levothyroxine (L-T(4)) therapy. The objective of this study was to evaluate how the individual serum T(3) level changes between preop...

journal_title：European journal of endocrinology

authors： Ito M,Miyauchi A,Morita S,Kudo T,Nishihara E,Kihara M,Takamura Y,Ito Y,Kobayashi K,Miya A,Kubota S,Amino N

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE:The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematolog...

journal_title：European journal of endocrinology

authors： Vivanco M,Dalle JH,Alberti C,Lescoeur B,Yakouben K,Carel JC,Baruchel A,Léger J

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. DESIGN:The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease. METHODS:TSH, free th...

journal_title：European journal of endocrinology

authors： van de Ven AC,Netea-Maier RT,de Vegt F,Ross HA,Sweep FC,Kiemeney LA,Smit JW,Hermus AR,den Heijer M

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To analyse trends in diagnostic practices of thyroid diseases and to relate them to the increase in thyroid cancer incidence in France over time. DESIGN:From 1980 to 2000, a French retrospective multicentric (three endocrinology and three nuclear medicine centres) study of thyroid diseases was conducted on 2...

journal_title：European journal of endocrinology

authors： Leenhardt L,Bernier MO,Boin-Pineau MH,Conte Devolx B,Maréchaud R,Niccoli-Sire P,Nocaudie M,Orgiazzi J,Schlumberger M,Wémeau JL,Chérie-Challine L,De Vathaire F

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:The type 2 deiodinase (D2) is a key enzyme for intracellular triiodothyronine (T(3)) generation. A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. Our aim was to evaluate whether the D2 Thr92Ala polymorphi...

journal_title：European journal of endocrinology

authors： Dora JM,Machado WE,Rheinheimer J,Crispim D,Maia AL

更新日期：2010-09-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is a familial syndrome characterized by parathyroid, enteropancreatic and pituitary tumors. The gene responsible for this syndrome is localized at chromosomal 11q13 region and DNA markers from this region cosegregate with the disease. The recent identification of the MEN1 ge...

journal_title：European journal of endocrinology

authors： Morelli A,Falchetti A,Martineti V,Becherini L,Mark M,Friedman E,Brandi ML

更新日期：2000-02-01 00:00:00

abstract：:Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-e...

journal_title：European journal of endocrinology

authors： Chemaitilly W,Cohen LE

更新日期：2017-04-01 00:00:00

abstract：:The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4 complexes respectively. Mutations and deletions of the p16INK4A gene have been found in melanomas and many other types of tumors. To assess the role of the p16INK4A and p15NK4B genes in tumorigene...

journal_title：European journal of endocrinology

authors： Yoshimoto K,Tanaka C,Yamada S,Kimura T,Iwahana H,Sano T,Itakura M

更新日期：1997-01-01 00:00:00

abstract：:Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoos...

journal_title：European journal of endocrinology

authors： Aksglaede L,Juul A

更新日期：2013-03-15 00:00:00