In Reply: The MELAS phenotype may not only be determined by heteroplasmy of causative mtDNA variants.

abstract：OBJECTIVE:This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatm...

journal_title：European journal of endocrinology

authors： Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, ...

journal_title：European journal of endocrinology

authors： Zevenbergen C,Korevaar TI,Schuette A,Peeters RP,Medici M,Visser TJ,Schomburg L,Visser WE

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...

journal_title：European journal of endocrinology

authors： Rojo-Martínez G,Soriguer FJ,González-Romero S,Tinahones F,Moreno F,de Adana SR,Garriga MJ,Esteva I,García-Arnés J,Gómez-Zumaquero JM,García-Almeida JM

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Thyroid function parameters have been associated with obesity, but associations with the type of adiposity have not been examined. We used ultrasound (US) to assess regional adiposity and investigated associations of thyroid function with parameters of central obesity. DESIGN:Cross-sectional study. METHODS:...

journal_title：European journal of endocrinology

authors： Alevizaki M,Saltiki K,Voidonikola P,Mantzou E,Papamichael C,Stamatelopoulos K

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Previously, it has been demonstrated that receptor protein tyrosine phosphatase sigma (RPTPsigma) is involved in glucose homeostasis and insulin signaling in several animal models. The aim of this study was to evaluate whether polymorphisms in this gene influence the development of type 2 diabetes (T2D) in hu...

journal_title：European journal of endocrinology

authors： Långberg EC,Gu HF,Nordman S,Efendic S,Ostenson CG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:The evidence that stress may provoke Graves' hyperthyroidism in genetically susceptible subjects is substantial. Whether exposure to stress is related to the severity of thyrotoxicosis has not been studied. Advancing age is associated with not only less severe Graves' hyperthyroidism but also self-reported st...

journal_title：European journal of endocrinology

authors： Vos XG,Smit N,Endert E,Brosschot JF,Tijssen JG,Wiersinga WM

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Adrenocorticotropic hormone (ACTH) is the primary secretagogue stimulating secretion of adrenal androgens (AA). Yet, genetic and environmental factors are assumed to play a determining role in the regulation of their biosynthesis and thus might explain the high variability of AA levels. Here we investigate th...

journal_title：European journal of endocrinology

authors： Reisch N,Slawik M,Zwermann O,Beuschlein F,Reincke M

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...

journal_title：European journal of endocrinology

authors： Wunder DM,Yared M,Bersinger NA,Widmer D,Kretschmer R,Birkhäuser MH

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures and thiazolidinediones (TZDs) increase this risk. TZDs stimulate the expression of sclerostin, a negative regulator of bone formation, in vitro. Abnormal sclerostin production may, therefore, be involved in the pathogenesis of i...

journal_title：European journal of endocrinology

authors： van Lierop AH,Hamdy NA,van der Meer RW,Jonker JT,Lamb HJ,Rijzewijk LJ,Diamant M,Romijn JA,Smit JW,Papapoulos SE

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Gastric carcinoid tumours type 1 (GCA1) originate from hyperplastic enterochromaffin-like (ECL) cells secondary to hypergastrinaemia. Treatment with somatostatin analogues (SSA) might impede ECL-cell hyperplasia by suppressing gastrin secretion and/or by a direct anti-proliferative effect on ECL cells. We co...

journal_title：European journal of endocrinology

authors： Grozinsky-Glasberg S,Kaltsas G,Gur C,Gal E,Thomas D,Fichman S,Alexandraki K,Barak D,Glaser B,Shimon I,Gross DJ

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:We conducted a prospective phase II clinical trial to determine the efficacy of sorafenib in patients with advanced radio-iodine refractory differentiated thyroid cancer. In this article, the long-term results are presented. PATIENTS AND METHODS:Thirty-one patients with progressive metastatic or locally adva...

journal_title：European journal of endocrinology

authors： Schneider TC,Abdulrahman RM,Corssmit EP,Morreau H,Smit JW,Kapiteijn E

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...

journal_title：European journal of endocrinology

authors： Correa P,Akerstrom G,Westin G

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin®. Local tolerability and treatment satisfaction were also assessed. DESIGN:26-week randomized, con...

journal_title：European journal of endocrinology

authors： Johannsson G,Feldt-Rasmussen U,Håkonsson IH,Biering H,Rodien P,Tahara S,Toogood A,Rasmussen MH,REAL 2 Study Group.

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

journal_title：European journal of endocrinology

authors： Salvatori R,Fan X,Veldhuis JD,Couch R

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Based on our clinical experience with combined gene therapy of glioblastoma, we developed a retroviral vector expressing two therapeutic genes (i.e. thymidine kinase of herpes simplex virus, HSV-TK, and interleukin-2, IL-2) and evaluated its efficiency in vitro and in vivo. METHODS:Expression of t...

journal_title：European journal of endocrinology

authors： Barzon L,Bonaguro R,Castagliuolo I,Chilosi M,Franchin E,Del Vecchio C,Giaretta I,Boscaro M,Palù G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...

journal_title：European journal of endocrinology

authors： Dimitriadis G,Maratou E,Boutati E,Kollias A,Tsegka K,Alevizaki M,Peppa M,Raptis SA,Hadjidakis DJ

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:The somatic point mutation in the BRAF gene, which results in a valine-to-glutamate substitution at residue 600 (BRAF(V600E)), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence is varyingly reported in different studies, and its expression in the follicular variant PTC is cont...

journal_title：European journal of endocrinology

authors： Sapio MR,Posca D,Troncone G,Pettinato G,Palombini L,Rossi G,Fenzi G,Vitale M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Recent observational studies have established progression and recurrence rates of pituitary adenomas. However, it is still unknown how individual pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. The objective of this study was to define a growth model for non-func...

journal_title：European journal of endocrinology

authors： Honegger J,Zimmermann S,Psaras T,Petrick M,Mittelbronn M,Ernemann U,Reincke M,Dietz K

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To investigate the frequencies of the major maturity-onset diabetes of the young (MODY) subtypes in a panel of Spanish families and to assess phenotypic differences in patients with the different subtypes of MODY. METHODS:Forty-eight subjects from twenty families with clinical diagnosis of MODY were studied....

journal_title：European journal of endocrinology

authors： Costa A,Bescós M,Velho G,Chêvre J,Vidal J,Sesmilo G,Bellanné-Chantelot C,Froguel P,Casamitjana R,Rivera-Fillat F,Gomis R,Conget I

更新日期：2000-04-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms of TSH receptor (TSHR) activation and intramolecular signal transduction are largely unknown. Deletion of the extracellular domain (ECD) of the TSHR results in increased constitutive activity, which suggests a self-inhibitory interaction between the ECD and the extracellular loops (EC...

journal_title：European journal of endocrinology

authors： Neumann S,Claus M,Paschke R

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The insulin-resistant state of the polycystic ovary syndrome (PCOS) was found to be associated with a decreased glucose transporter GLUT4 expression in the insulin target tissues. This study was performed to explore whether the well-known clinical, hormonal and metabolic efficacy of metformin or rosiglitazone...

journal_title：European journal of endocrinology

authors： Jensterle M,Janez A,Mlinar B,Marc J,Prezelj J,Pfeifer M

更新日期：2008-06-01 00:00:00

abstract：:Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental ho...

journal_title：European journal of endocrinology

authors： Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

更新日期：2010-03-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：European journal of endocrinology

authors： Funder J,Carey R,Fardella C,Gomez-Sanchez C,Mantero F,Stowasser M,Young W,Montori VM

更新日期：2009-09-30 00:00:00

abstract：:To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

journal_title：European journal of endocrinology

authors： Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

更新日期：1995-09-01 00:00:00

abstract：:Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 +/- 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed ...

journal_title：European journal of endocrinology

authors： Sylvén L,Hagenfeldt K,Ringertz H

更新日期：1995-01-01 00:00:00

abstract：:For many years, it has been well documented that combined hormonal contraceptives increase the risk of venous thromboembolism (VTE). The third-generation pill use (desogestrel or gestodene (GSD)) is associated with an increased VTE risk as compared with second-generation (levonorgestrel) pill use. Other progestins suc...

journal_title：European journal of endocrinology

authors： Hugon-Rodin J,Gompel A,Plu-Bureau G

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES:i) To review current management of AI and the unmet medica...

journal_title：European journal of endocrinology

authors： Grossman A,Johannsson G,Quinkler M,Zelissen P

更新日期：2013-10-21 00:00:00

abstract：:123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy scanning is commonly used in the imaging of phaeochromocytoma (and paraganglioma) to confirm the site of disease and whether any spread has occurred. However, 123I-MIBG imaging is negative in 15% of cases of benign phaeochromocytoma and around 50% of cases of malig...

journal_title：European journal of endocrinology

authors： Mackenzie IS,Gurnell M,Balan KK,Simpson H,Chatterjee K,Brown MJ

更新日期：2007-10-01 00:00:00