Abstract:
:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenchymal stem cells toward osteoblasts, and insulin-like growth factor I (IGF-I) enhances the function of mature osteoblasts. The activity of Wnt and IGF-I is controlled by proteins that bind to the growth factor or to its receptors. Sclerostin is a Wnt antagonist that binds to Wnt co-receptors and prevents Wnt signal activation. Teriparatide, a 1-34 amino terminal fragment of parathyroid hormone (PTH), and abaloparatide, a modified 1-34 amino terminal fragment of PTH-related peptide (PTHrp), induce IGF-I, increase bone mineral density (BMD), reduce the incidence of vertebral and non-vertebral fractures and are approved for the treatment of postmenopausal osteoporosis. Romosozumab, a humanized anti-sclerostin antibody, increases bone formation, decreases bone resorption, increases BMD and reduces the incidence of vertebral fractures. An increased incidence of cardiovascular events has been associated with romosozumab, which is yet to be approved for the treatment of osteoporosis. In conclusion, cell and molecular studies have formed the foundation for the development of new anabolic therapies for osteoporosis with proven efficacy on the incidence of new fractures.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Canalis Edoi
10.1530/EJE-17-0920subject
Has Abstractpub_date
2018-02-01 00:00:00pages
R33-R44issue
2eissn
0804-4643issn
1479-683Xpii
EJE-17-0920journal_volume
178pub_type
杂志文章,评审abstract:BACKGROUND:Fetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals. OBJECTIVE:To evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA)...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0286
更新日期:2007-11-01 00:00:00
abstract::To assess the metabolic effects of thyroid disease, body composition was determined by bioimpedance analysis (BIA) in 72 patients with untreated hyperthyroidism (mean age 48.7 +/- 1.9 years) and 26 patients with untreated hypothyroidism (63.8 +/- 3.4 years). Bioelectrical whole body resistance (R) and reactance (Xc) w...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1360493
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and method...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-09-0547
更新日期:2009-12-01 00:00:00
abstract:UNLABELLED:Chronic exposure to hypercortisolism has significant impact on patient's health and health-related quality of life (HRQoL), as demonstrated with generic questionnaires. We have developed a disease-generated questionnaire to evaluate HRQoL in patients with Cushing's syndrome (CS; CushingQoL). OBJECTIVE:Valid...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0762
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Some cases of apparently idiopathic GH deficiency (GHD) may be caused by pituitary autoimmunity. OBJECTIVE:To study the variations in pituitary function and antipituitary antibodies (APA) from childhood to transition age in patients with apparently idiopathic GHD. DESIGN:We conducted a longitudinal study. ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-15-0766
更新日期:2016-03-01 00:00:00
abstract::Patients with pituitary tumours, ensuing hormonal abnormalities and mass effects are usually followed in multidisciplinary pituitary clinics and can represent a management challenge even during the times of non-pandemic. The COVID-19 pandemic has put on hold routine medical care for hundreds of millions of patients ar...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-20-0473
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:Previous evidence has suggested that a low sex hormone-binding globulin (SHBG) concentration is associated with insulin-resistance and a low adiponectin concentration. We investigated the association between SHBG and the risk of hyperglycemia in each sex and we determined potential interactions between SHBG a...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0202
更新日期:2009-07-01 00:00:00
abstract:CONTEXT AND OBJECTIVE:The precise diagnosis of partially virilised women with 46,XY disorders of sex development (DSD) is often obscure. In practice, this group often comes under the poorly defined, clinically based label of partial androgen insensitivity syndrome (PAIS). In a previous study, we found that 5α-reductase...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-14-0994
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CA...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0014
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:The role of preoperative localisation of abnormal parathyroid glands remains controversial but is particularly relevant to the management of patients with recurrent or persistent hyperparathyroidism and familial syndromes. We report our experience of the use of selective parathyroid venous sampling (PVS) in t...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02304
更新日期:2006-12-01 00:00:00
abstract::A 27-year-old woman with no previous personal or family history of thyroid disease was referred to us for the evaluation of thyroid nodule, five months postpartum. Thyroid scintigraphy demonstrated a left cold nodule. Fine needle aspiration cytology of the nodule showed a mixture of colloid, follicular cells and lymph...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1380562
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Autoimmune polyendocrine syndrome type I (APS I) is a monogenic disease affecting endocrine glands and other organs due to mutations of the autoimmune regulator (AIRE) gene. There is a wide variability in clinical phenotypes in patients with APS I, which makes the diagnosis a challenge. OBJECTIVE:To screen ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0843
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To detect exogenous recombinant human GH (rhGH) abuse in female athletes. DESIGN:GH-dependent markers were assayed in serum of 100 female athletes (control group) and in a subgroup of nine female subjects treated with rhGH (0.09 IU/kg body weight, 6 days/week for 3 weeks). METHODS:Cut-off values (mean+2 s.d...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0884
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH). METHODS:In a retrospective study we analyzed the GnRHR and the GPR54 genes of 45 IHH patients and ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02031
更新日期:2005-12-01 00:00:00
abstract::The present study focuses on the pathogenesis of increased frequency of large-vessel disease in diabetes. The diabetic arterial wall displays characteristic alterations of the extracellular matrix secreted by arterial smooth-muscle cells. The effects of insulin and growth hormone on the synthesis of sulphate-labelled ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1340326
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:While anti-pituitary antibodies (APAs) were detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far. DESIGN:The aim of this study ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0647
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. The aim of this cross-sectional, controlled study was to evaluate growth and intellectual outcome in children with persistent SH who have never been treated with levothyroxine. DESIGN AND M...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-10-0979
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Many investigators believe that basal adrenal venous sampling (AVS) should be done simultaneously, whereas others opt for sequential AVS for simplicity and reduced cost. This study aimed to evaluate the concordance of sequential and simultaneous AVS methods. DESIGN AND METHODS:Between 1989 and 2015, bilatera...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-16-0701
更新日期:2017-02-01 00:00:00
abstract:CONTEXT AND OBJECTIVE:Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0069
更新日期:2008-07-01 00:00:00
abstract::Several bone matrix protein constituents, including the major component collagen type I and the hydroxyapatite binding protein, osteocalcin, have been implicated in the regulation of bone turnover. Cortical bone osteocalcin, collagen and mineral content were studied in autosomal dominant osteopetrosis type I (ADO), a ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1300592
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:A substantial proportion of all pheochromocytomas is currently detected during the evaluation of an adrenal incidentaloma. Recently, it has been suggested that biochemical testing to rule out pheochromocytoma is unnecessary in case of an adrenal incidentaloma with an unenhanced attenuation value ≤10 Hounsfie...
journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
doi:10.1530/EJE-18-0006
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes. MATERIALS AND METHODS:Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.6), in the presence or absence o...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1430119
更新日期:2000-07-01 00:00:00
abstract::In addition to the classical hormones, the production of numerous polypeptide growth factors, cytokines, vasogenic substances and neuropeptides by pituitary cells has been demonstrated. Expression of the corresponding receptors on pituitary cells enables these factors to influence growth and function of the pituitary ...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.1350515
更新日期:1996-11-01 00:00:00
abstract::All children and adolescents with Graves' disease in the county of Uppsala (catchment area population 250,000) treated between 1970 and 1994 were evaluated in a retrospective study. The material comprised 31 patients with a mean age of 11 years (range 4-16), 29 (94%) of whom were girls, and four (13%) of the patients ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1340710
更新日期:1996-06-01 00:00:00
abstract::Prediction models are of a great assistance for predicting the development of a disease, detecting or screening undiagnosed patients, predicting the effectiveness of a treatment and helping toward better decision-making. Recently, three predictive scores in the field of autoimmune thyroid disease (AITD) have been intr...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-19-0234
更新日期:2019-09-01 00:00:00
abstract::Vasoactive and angiogenic factors are involved in the autocrine/paracrine thyroid regulation of microvascular bed during goiter development. In the thyroid of old mice, the presence of slowly functioning ('cold') follicles allowed us to study the microvascular regulation of each follicle in correlation with the immuno...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1420651
更新日期:2000-06-01 00:00:00
abstract::Paragangliomas (PGLs) are rare vascular, neuroendocrine tumors of paraganglia, which are associated with either sympathetic tissue in adrenal (pheochromocytomas (PCCs)) and extraadrenal (sympathetic paraganglioma (sPGLs)) locations or parasympathetic tissue of the head and neck paragangliomas (HNPGLs). As HNPGLs are u...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-14-0396
更新日期:2014-12-01 00:00:00
abstract::Regulatory actions of angiotensin II (AngII), which is involved in the pathophysiology of hypertension and also participates in cell proliferation and cell differentiation, are mainly mediated by AngII type 1 (AT1) receptor. Recently, activating mutations of receptors causing hyperfunctioning endocrine diseases have b...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1370262
更新日期:1997-09-01 00:00:00
abstract::Prostate growth is known to be controlled by steroids such as androgens and estradiol. For this reason steroids (estradiol, adrenal androgens) or steroid inhibitors are commonly used as palliative treatments for prostate carcinoma. In view of the pivotal role played by Ca2+ ions in cell proliferation, we decided to in...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1350367
更新日期:1996-09-01 00:00:00
abstract:Objective:Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expressi...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-18-0305
更新日期:2018-10-01 00:00:00