Pregnancy and pituitary disorders.

abstract：:Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a re...

journal_title：European journal of endocrinology

authors： Jaquet D,Khallouf E,Lévy-Marchal C,Czernichow P

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The current guidelines for the management of adrenal incidentaloma advise hormonal and radiological follow-up of patients for 2-5 years after the initial diagnosis. However, the vast majority of adrenal incidentaloma are non-functional benign cortical adenomas that require no treatment, so the routine applica...

journal_title：European journal of endocrinology

authors： Kastelan D,Kraljevic I,Dusek T,Knezevic N,Solak M,Gardijan B,Kralik M,Poljicanin T,Skoric-Polovina T,Kastelan Z

更新日期：2015-08-01 00:00:00

abstract：:Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), arising from gain-of-function mutations in Gαs, and cutaneous skeletal hypophosphatemia syndrome (CSHS), arising from gain-of-function mutations in the Ras/MAPK pathway, are strikingly complex, mosaic diseases with overlapping phenotypes. Both disorders are defined ...

journal_title：European journal of endocrinology

authors： de Castro LF,Ovejero D,Boyce AM

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Betaglycan is a membrane-anchored proteoglycan involved in mediating the passage of transforming growth factor-beta (TGF-beta), inhibin and activin activities into cells. TGF-beta and inhibin-related proteins are growth factors that are expressed by several tIssues and in pregnancy. They have a function in m...

journal_title：European journal of endocrinology

authors： Ciarmela P,Florio P,Toti P,Grasso D,Santopietro R,Tosi P,Petraglia F

更新日期：2003-11-01 00:00:00

abstract：:Effective diabetes care requires a partnership between prepared, proactive practice teams and informed, activated patients. Diabetes education helps to overcome many of the barriers to effective self-management by enabling people with diabetes to make informed decisions about their day-to-day self-care. Both psychosoc...

journal_title：European journal of endocrinology

authors： Funnell MM

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...

journal_title：European journal of endocrinology

authors： Wickman S,Saukkonen T,Dunkel L

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:This retrospective study describes the role of serum thyroglobulin (Tg) in relation to tumor characteristics in the prediction of persistent/recurrent disease in patients with differentiated thyroid cancer (DTC) with negative Tg at the time of ablation. DESIGN:Between 1989 and 2006, 94 out of 346 (27%) patie...

journal_title：European journal of endocrinology

authors： Phan HT,Jager PL,van der Wal JE,Sluiter WJ,Plukker JT,Dierckx RA,Wolffenbuttel BH,Links TP

更新日期：2008-01-01 00:00:00

abstract：:As differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of disease, so that previous follow-up protocols based mostly on data ...

journal_title：European journal of endocrinology

authors： Schlumberger M,Pacini F,Wiersinga WM,Toft A,Smit JW,Sanchez Franco F,Lind P,Limbert E,Jarzab B,Jamar F,Duntas L,Cohen O,Berg G

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:To examine the relationship between maternal TSH and free thyroxine (FT(4)) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death. METHOD:Cohort study of 2497 Dutch women. TSH, FT(4), and thyroid peroxidase antibodies concentrations were determined at first booking. Child lo...

journal_title：European journal of endocrinology

authors： Benhadi N,Wiersinga WM,Reitsma JB,Vrijkotte TG,Bonsel GJ

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Though transsphenoidal surgery remains the first-line treatment of Cushing's disease, recurrence occurs frequently. Conventional radiotherapy and anticortisolic drugs both have adverse effects. Stereotactic radiosurgery needs to be evaluated more precisely. The aim of this study was to determine long-term hor...

journal_title：European journal of endocrinology

authors： Castinetti F,Nagai M,Dufour H,Kuhn JM,Morange I,Jaquet P,Conte-Devolx B,Regis J,Brue T

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare physical activity and biochemical markers with bone mineral acquisition in rhythmic gymnasts and ballet dancers. METHODS:Weight, height, body mass index, nutritional intake, bone age and menstrual histories were analyzed in nine rhythmic gymnasts, twelve ballet dancers and fourteen con...

journal_title：European journal of endocrinology

authors： Muñoz MT,de la Piedra C,Barrios V,Garrido G,Argente J

更新日期：2004-10-01 00:00:00

abstract：CONTEXT:Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE:To improve the diagnostic accuracy of GH-releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI and sex and established normative data for an automatic immunoassay sp...

journal_title：European journal of endocrinology

authors： Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS:Study cohort included 8...

journal_title：European journal of endocrinology

authors： Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, ...

journal_title：European journal of endocrinology

authors： Zevenbergen C,Korevaar TI,Schuette A,Peeters RP,Medici M,Visser TJ,Schomburg L,Visser WE

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:In order to characterize urinary gonadotropin peptide (UGP) as an acute phase reactant, we focused on the UGP levels after surgical operation. DESIGN:Fifty cases of gastrointestinal cancer, 4 cases of cancers of other organs and 13 cases of benign digestive diseases were enrolled into this study. METHODS:UG...

journal_title：European journal of endocrinology

authors： Motoo Y,Watanabe H,Okai T,Sawabu N

更新日期：1999-06-01 00:00:00

abstract：:Nelson's syndrome is a potentially life-threatening condition that does not infrequently develop following total bilateral adrenalectomy (TBA) for the treatment of Cushing's disease. In this review article, we discuss some controversial aspects of Nelson's syndrome including diagnosis, predictive factors, aetiology, p...

journal_title：European journal of endocrinology

authors： Barber TM,Adams E,Ansorge O,Byrne JV,Karavitaki N,Wass JA

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood. OBJECTIVE:To investigate whether childhood CRT leads to altered sleep-wakefulness organization in adulthood, and to identify the determinants of such alterations. SUBJECTS AND METHODS:Subjective...

journal_title：European journal of endocrinology

authors： Van Someren EJ,Swart-Heikens J,Endert E,Bisschop PH,Swaab DF,Bakker PJ,Romijn JA,Fliers E

更新日期：2004-04-01 00:00:00

abstract：Objective:Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expressi...

journal_title：European journal of endocrinology

authors： Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

更新日期：2018-10-01 00:00:00

abstract：CONTEXT:There is evidence to suggest that IGF-I plays a role in regulating bone turnover. OBJECTIVE:To evaluate the relationships between serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3), and bone metabolism markers in healthy children. DESIGN AND SETTING:Prospective cross-sectional study. SUBJECTS ...

journal_title：European journal of endocrinology

authors： Léger J,Mercat I,Alberti C,Chevenne D,Armoogum P,Tichet J,Czernichow P

更新日期：2007-11-01 00:00:00

abstract：:The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11beta-hydroxysteroid dehydrogenase. In other ti...

journal_title：European journal of endocrinology

authors： Wickert L,Watzka M,Bolkenius U,Bidlingmaier F,Ludwig M

更新日期：1998-06-01 00:00:00

abstract：CONTEXT:Vitamin D deficiency has been identified as a risk factor for a number of autoimmune diseases including type 1 diabetes and multiple sclerosis. OBJECTIVE:We hypothesized that low levels of vitamin D are related to the early stages of autoimmune thyroid disease (AITD). DESIGN:Two case-control studies were perf...

journal_title：European journal of endocrinology

authors： Effraimidis G,Badenhoop K,Tijssen JG,Wiersinga WM

更新日期：2012-07-01 00:00:00

abstract：:Osteoporosis is being increasingly recognised in paediatric practice as a consequence of several factors. These include the increasing complexity of chronic conditions and the associated treatments managed by paediatricians. In addition, the improved care provided to children with chronic illness has led to many of th...

journal_title：European journal of endocrinology

authors： Shaw NJ

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Leptin, which is the product of the obese gene, is believed to play important roles in pubertal development and reproductive function in females. In a study using adult male rats, it was found that leptin stimulated secretion of gonadotropin from the pituitary in a dose-related manner. However, there has bee...

journal_title：European journal of endocrinology

authors： Ogura K,Irahara M,Kiyokawa M,Tezuka M,Matsuzaki T,Yasui T,Kamada M,Aono T

更新日期：2001-06-01 00:00:00

abstract：:The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

journal_title：European journal of endocrinology

authors： Gründker C,Günthert AR,Westphalen S,Emons G

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Validate the acromegaly quality of life (AcroQoL) questionnaire as a disease-generated questionnaire, which analyses physical and psychological domains, the latter subdivided into appearance and personal relationship sub-scales, to evaluate health-related quality of life (HRQoL) in acromegaly. DESIGN:Prospec...

journal_title：European journal of endocrinology

authors： Webb SM,Badia X,Surinach NL,Spanish AcroQol Study Group.

更新日期：2006-08-01 00:00:00

abstract：Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

journal_title：European journal of endocrinology

authors： Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes. MATERIALS AND METHODS:Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.6), in the presence or absence o...

journal_title：European journal of endocrinology

authors： Centanni M,Canettieri G,Viceconti N,Sibilla R,Bei A,Andreoli M

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 1...

journal_title：European journal of endocrinology

authors： Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:In order to better understand how the IGF-I axis is affected by exogenous IGF-I, this study compared the effects of a constant s.c. infusion of IGF-I with that of twice-daily injections of IGF-I in young adult female rhesus monkeys. Clinical studies suggest that circulating concentrations of insulin-like grow...

journal_title：European journal of endocrinology

authors： Wilson ME,Lackey SL

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Ghrelin is an orexigenic 28-amino acid peptide produced by the stomach. Circulating ghrelin levels rise shortly before and fall shortly after every meal. Peptide YY (PYY), an anorexigenic 36-amino acid peptide, is secreted primarily from the intestinal mucosa of the ileum and large intestine. Plasma...

journal_title：European journal of endocrinology

authors： Bizzarri C,Rigamonti AE,Luce A,Cappa M,Cella SG,Berini J,Sartorio A,Müller EE,Salvatoni A

更新日期：2010-03-01 00:00:00