当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Nelson's syndrome.

Nelson's syndrome.

Abstract：

:Nelson's syndrome is a potentially life-threatening condition that does not infrequently develop following total bilateral adrenalectomy (TBA) for the treatment of Cushing's disease. In this review article, we discuss some controversial aspects of Nelson's syndrome including diagnosis, predictive factors, aetiology, pathology and management based on data from the existing literature and the experience of our own tertiary centre. Definitive diagnostic criteria for Nelson's syndrome are lacking. We argue in favour of a new set of criteria. We propose that Nelson's syndrome should be diagnosed in any patient with prior TBA for the treatment of Cushing's disease and with at least one of the following criteria: i) an expanding pituitary mass lesion compared with pre-TBA images; ii) an elevated 0800 h plasma level of ACTH (>500 ng/l) in addition to progressive elevations of ACTH (a rise of >30%) on at least three consecutive occasions. Regarding predictive factors for the development of Nelson's syndrome post TBA, current evidence favours the presence of residual pituitary tumour on magnetic resonance imaging (MRI) post transsphenoidal surgery (TSS); an aggressive subtype of corticotrophinoma (based on MRI growth rapidity and histology of TSS samples); lack of prophylactic neoadjuvant pituitary radiotherapy at the time of TBA and a rapid rise of ACTH levels in year 1 post TBA. Finally, more studies are needed to assess the efficacy of therapeutic strategies in Nelson's syndrome, including the alkylating agent, temozolomide, which holds promise as a novel and effective therapeutic agent in the treatment of associated aggressive corticotroph tumours. It is timely to review these controversies and to suggest guidelines for future audit.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Barber TM,Adams E,Ansorge O,Byrne JV,Karavitaki N,Wass JA

doi

10.1530/EJE-10-0466

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

495-507

issue

4

eissn

0804-4643

issn

1479-683X

pii

EJE-10-0466

journal_volume

163

pub_type

杂志文章,评审

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • A four year dose-response study of recombinant human growth hormone treatment of growth hormone deficient children: effects on growth, bone growth and bone mineralization.

    abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1420042

    authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

    更新日期：2000-01-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: The role of confirmatory tests in the diagnosis of primary aldosteronism.

    abstract：:The strategy for diagnosis of primary aldosteronism (PA) in the hypertensive population includes firstly a screening step, based on the measurement of plasma aldosterone-to-renin ratio (ARR), a test which must have high sensitivity, and secondly a confirmatory step based on the demonstration of excessive aldosterone p...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-18-0704

    authors： Morera J,Reznik Y

    更新日期：2019-02-01 00:00:00

  • Minichromosome maintenance protein 7 as prognostic marker of tumor aggressiveness in pituitary adenoma patients.

    abstract：BACKGROUND:Ki-67 labeling index (LI) is currently regarded as a useful prognostic marker of pituitary adenoma (PA) clinical behavior, although its relevance as a reliable clinical indicator is far from being universally accepted, since both validations and criticisms are found in the literature. Minichromosome maintena...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0586

    authors： Coli A,Asa SL,Fadda G,Scannone D,Chiloiro S,De Marinis L,Lauretti L,Ranelletti FO,Lauriola L

    更新日期：2016-03-01 00:00:00

  • Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

    abstract：OBJECTIVE:The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. DES...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-06-0607

    authors： Lapauw B,Goemaere S,Crabbe P,Kaufman JM,Ruige JB

    更新日期：2007-03-01 00:00:00

  • The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.

    abstract：OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-17-1017

    authors： Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

    更新日期：2018-06-01 00:00:00

  • Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line.

    abstract：OBJECTIVE:Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim wa...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410035

    authors： Gallo M,Aragno M,Gatto V,Tamagno E,Brignardello E,Manti R,Danni O,Boccuzzi G

    更新日期：1999-07-01 00:00:00

  • The effect of long-term, non-suppressive levothyroxine treatment on quantitative ultrasonometry of bone in women.

    abstract：OBJECTIVE:To evaluate the impact of long-term, non-suppressive levothyroxine (L-T(4)) treatment on quantitative ultrasonometry in women. DESIGN:This was a case-control study. SUBJECTS AND METHODS:Altogether 667 women (mean age+/-s.d., 49.5+/-13.1 years) were studied. Of these, 156 (23%) had non-toxic goitre or hypoth...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1420445

    authors： Hadji P,Hars O,Sturm G,Bauer T,Emons G,Schulz KD

    更新日期：2000-05-01 00:00:00

  • Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study.

    abstract：AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-15-0176

    authors： Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

    更新日期：2015-08-01 00:00:00

  • Sex 'n' drugs 'n' rock 'n' roll: the meaning and social consequences of pubertal timing.

    abstract：:This is a brief review of the normal changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker for an individual's transition from a non-reproduc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.151u151

    authors： Waylen A,Wolke D

    更新日期：2004-11-01 00:00:00

  • Effectiveness of eplerenone or spironolactone treatment in preserving renal function in primary aldosteronism.

    abstract：OBJECTIVE:Primary aldosteronism (PA) has deleterious effects on kidney function independent of blood pressure levels. Up to now, data on effectiveness of different PA therapies regarding renal function are scarce. DESIGN AND METHODS:This prospective multi-center study included 29 patients with newly diagnosed PA evalu...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1530/EJE-12-0631

    authors： Fourkiotis V,Vonend O,Diederich S,Fischer E,Lang K,Endres S,Beuschlein F,Willenberg HS,Rump LC,Allolio B,Reincke M,Quinkler M,Mephisto Study Group.

    更新日期：2012-12-10 00:00:00

  • The genetics of phaeochromocytoma: using clinical features to guide genetic testing.

    abstract：:Phaeochromocytoma is a rare, usually benign, tumour predominantly managed by endocrinologists. Over the last decade, major advances have been made in understanding the molecular genetic basis of adrenal and extra-adrenal phaeochromocytoma (also referred to as adrenal phaeochromocytoma (aPCA) and extra-adrenal function...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-11-0497

    authors： Jafri M,Maher ER

    更新日期：2012-02-01 00:00:00

  • A carnivore species (Canis familiaris) expresses circadian melatonin rhythm in the peripheral blood and melatonin receptors in the brain.

    abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1310191

    authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

    更新日期：1994-08-01 00:00:00

  • Calcium mobilization is a prerequisite for the expression of phorbol ester-stimulated luteinizing hormone secretion from pituitaries of male and acutely ovariectomized rats.

    abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300151

    authors： Das S,Fahmy NW,Bourne GA

    更新日期：1994-02-01 00:00:00

  • Pituitary response to luteinizing hormone-releasing hormone in women with variant luteinizing hormone.

    abstract：OBJECTIVE:To assess the LH response of the pituitary gland to GnRH stimulation in healthy women with a mutant beta-subunit (Trp8 to Arg8 and Ile15 to Thr15). DESIGN:Clinical study. PATIENTS:We studied 40 healthy non-pregnant Japanese women of known zygosity for the LH beta-subunit gene (3 homozygotes for the mutant g...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1430375

    authors： Takahashi K,Kurioka H,Ozaki T,Kanasaki H,Miyazaki K,Karino K

    更新日期：2000-09-01 00:00:00

  • Autocrine and paracrine roles of polypeptide growth factors, cytokines and vasogenic substances in normal and tumorous pituitary function and growth: a review.

    abstract：:In addition to the classical hormones, the production of numerous polypeptide growth factors, cytokines, vasogenic substances and neuropeptides by pituitary cells has been demonstrated. Expression of the corresponding receptors on pituitary cells enables these factors to influence growth and function of the pituitary ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1350515

    authors： Renner U,Pagotto U,Arzt E,Stalla GK

    更新日期：1996-11-01 00:00:00

  • Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR.

    abstract：OBJECTIVE:This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatm...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1530/eje.0.1510317

    authors： Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

    更新日期：2004-09-01 00:00:00

  • Endocrine health conditions in adult survivors of childhood cancer: the need for specialized adult-focused follow-up clinics.

    abstract：BACKGROUND:Survival rates among childhood cancer survivors (CCS) have enormously increased in the last 40 years. However, this improvement has been achieved at the expense of serious late effects that frequently involve the endocrine system. AIM:To evaluate the cumulative incidence of endocrine diseases in a cohort of...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-1043

    authors： Brignardello E,Felicetti F,Castiglione A,Chiabotto P,Corrias A,Fagioli F,Ciccone G,Boccuzzi G

    更新日期：2013-02-20 00:00:00

  • DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments.

    abstract：:Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-e...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-17-0054

    authors： Chemaitilly W,Cohen LE

    更新日期：2017-04-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.

    abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-17-0920

    authors： Canalis E

    更新日期：2018-02-01 00:00:00

  • TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease.

    abstract：OBJECTIVE:Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or r...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0280

    authors： Manolakis AC,Kapsoritakis AN,Tiaka EK,Sidiropoulos A,Gerovassili A,Satra M,Vamvakopoulou D,Tsiopoulos F,Papanas N,Skoularigis I,Potamianos SP,Vamvakopoulos N

    更新日期：2011-08-01 00:00:00

  • The role of estrogens for male bone health.

    abstract：:Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-09-0118

    authors： Ohlsson C,Vandenput L

    更新日期：2009-06-01 00:00:00

  • Testicular function and fertility in men with Klinefelter syndrome: a review.

    abstract：:Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoos...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-12-0934

    authors： Aksglaede L,Juul A

    更新日期：2013-03-15 00:00:00

  • Follow-up and management of differentiated thyroid carcinoma: a European perspective in clinical practice.

    abstract：:As differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of disease, so that previous follow-up protocols based mostly on data ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1510539

    authors： Schlumberger M,Pacini F,Wiersinga WM,Toft A,Smit JW,Sanchez Franco F,Lind P,Limbert E,Jarzab B,Jamar F,Duntas L,Cohen O,Berg G

    更新日期：2004-11-01 00:00:00

  • Quantitave and qualitative changes in vascular endothelial growth factor gene expression in glomeruli of patients with type 2 diabetes.

    abstract：OBJECTIVE:Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF 121, VEGF 165 and VEGF 189) and acts via two specific receptors: VEGF-R1 or Flt-1 and VEGF-R2 or KDR. VEGF plays an important role in the pathogenesis of diabetic retinopathy. Th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500799

    authors： Bortoloso E,Del Prete D,Dalla Vestra M,Gambaro G,Saller A,Antonucci F,Baggio B,Anglani F,Fioretto P

    更新日期：2004-06-01 00:00:00

  • Female gonadal development in XX patients with distal 9p monosomy.

    abstract：OBJECTIVE:A sex determining gene(s) has been mapped to a approximately 700 kb region distal to the exons of DMRT1 on 9p. The aim of this study was to examine gonadal developmental status in XX patients hemizygous for the 9p sex determining region. DESIGN:Clinical and molecular studies were performed in an 8-year-old g...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1450613

    authors： Ogata T,Muroya K,Ohashi H,Mochizuki H,Hasegawa T,Kaji M

    更新日期：2001-11-01 00:00:00

  • Fractionated radiotherapy and radiosurgery in acromegaly: analysis of 352 patients from the German Acromegaly Registry.

    abstract：Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0784

    authors： Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

    更新日期：2020-03-01 00:00:00

  • Pituitary-ovarian dysfunction in rats with induced nephrotic syndrome.

    abstract：:The reproductive hormonal profile was evaluated in female rats with experimental nephrotic syndrome induced with a single subcutaneous dose of puromycin aminonucleoside (PAN). Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P4), testosterone and 17 beta-estradiol (E2...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1320502

    authors： Menjívar M,Vilchis F,Cárdenas M,Cruz C,Merchant H,Pérez-Palacios G,Pedraza-Chaverri J

    更新日期：1995-04-01 00:00:00

  • Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas.

    abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0245

    authors： Tani Y,Inoshita N,Sugiyama T,Kato M,Yamada S,Shichiri M,Hirata Y

    更新日期：2010-10-01 00:00:00

  • Primary aldosteronism as a cause of secondary osteoporosis.

    abstract：OBJECTIVE:Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. DESIGN:Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. METHO...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-17-0417

    authors： Salcuni AS,Carnevale V,Battista C,Palmieri S,Eller-Vainicher C,Guarnieri V,Pugliese F,Guglielmi G,Desina G,Minisola S,Chiodini I,Scillitani A

    更新日期：2017-11-01 00:00:00

  • Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene.

    abstract：OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470591

    authors： Salvatori R,Fan X,Veldhuis JD,Couch R

    更新日期：2002-11-01 00:00:00