Testicular function and fertility in men with Klinefelter syndrome: a review.

abstract：OBJECTIVES:Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese ...

journal_title：European journal of endocrinology

authors： Pacifico L,Anania C,Osborn JF,Ferraro F,Bonci E,Olivero E,Chiesa C

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Leptin secretion is reduced by low temperatures in experimental animals, and this effect has been explained as an adaptive mechanism to cold environments. This study investigated the in vitro effects of cold exposure on human white adipose tissue. DESIGN:To understand whether the low temperature action is a ...

journal_title：European journal of endocrinology

authors： Peinó R,Piñeiro V,Gualillo O,Menéndez C,Brenlla J,Casabiell X,Diéguez C,Casanueva FF

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Previously, it has been demonstrated that receptor protein tyrosine phosphatase sigma (RPTPsigma) is involved in glucose homeostasis and insulin signaling in several animal models. The aim of this study was to evaluate whether polymorphisms in this gene influence the development of type 2 diabetes (T2D) in hu...

journal_title：European journal of endocrinology

authors： Långberg EC,Gu HF,Nordman S,Efendic S,Ostenson CG

更新日期：2007-10-01 00:00:00

abstract：CONTEXT:Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women. No previous study on long-term GH therapy in adults with childhood onset (CO) craniopharyngioma was identified. OBJECTIVE:To investigate CVD risk in adults with CO craniopharyn...

journal_title：European journal of endocrinology

authors： Holmer H,Ekman B,Björk J,Nordstöm CH,Popovic V,Siversson A,Erfurth EM

更新日期：2009-11-01 00:00:00

abstract：CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

journal_title：European journal of endocrinology

authors： Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:This study aimed to analyze the autonomic control of heart rate variability (HRV) in subjects receiving chronic l-thyroxine (l-T4) treatment after total thyroidectomy and (131)I therapy for differentiated thyroid carcinoma. METHODS:Blood pressure (BP) and sympatho-vagal activity (evaluated by power spectral ...

journal_title：European journal of endocrinology

authors： Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response ele...

journal_title：European journal of endocrinology

authors： Rao AS,Kremenevskaja N,Resch J,Brabant G

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

journal_title：European journal of endocrinology

authors： Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

更新日期：2003-10-01 00:00:00

abstract：:Descent of the testis from an intra-abdominal site in foetal life to an extracorporeal location after birth is a mandatory developmental process to ensure that the mature testis promotes normal spermatogenesis. The two phases of transabdominal and inguinoscrotal descent occur approximately during the first and last th...

journal_title：European journal of endocrinology

authors： Hughes IA,Acerini CL

更新日期：2008-12-01 00:00:00

abstract：Objective:Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponecti...

journal_title：European journal of endocrinology

authors： Kampmann FB,Thuesen ACB,Hjort L,Bjerregaard AA,Chavarro JE,Frystyk J,Bjerre M,Tetens I,Olsen SF,Vaag AA,Damm P,Grunnet LG

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat. METHODS:A computerized search was made from seven databa...

journal_title：European journal of endocrinology

authors： García-Hermoso A,Saavedra JM,Escalante Y,Sánchez-López M,Martínez-Vizcaíno V

更新日期：2014-10-01 00:00:00

abstract：:Pituitary adenomas are frequently occurring neoplasms that produce clinically significant disease in 1:1000 of the general population. The pathogenesis of pituitary tumors is a matter of interest as it could help to improve diagnosis and treatment. Until recently, however, disruptions in relatively few genes were know...

journal_title：European journal of endocrinology

authors： Vandeva S,Daly AF,Petrossians P,Zacharieva S,Beckers A

更新日期：2019-12-01 00:00:00

abstract：Objective:Statin therapy has been linked to an increased risk of type 2 diabetes in high-risk populations; however, the pathophysiology of this association remains to be clarified. We investigated glucagon suppression and its relationship with insulin resistance in prediabetic subjects undergoing atorvastatin therapy; ...

journal_title：European journal of endocrinology

authors： Urbano F,Di Pino A,Scicali R,Filippello A,Di Mauro S,Scamporrino A,Marchisello S,Rabuazzo AM,Purrello F,Piro S

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

journal_title：European journal of endocrinology

authors： Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:11beta-Hydroxylase and aldosterone synthase are two highly homologous genes involved in different forms of human hypertension and in different animal models of hypertension. It has been shown that the conservative substitution D147E in the human CYP11B2 gene results in an increased production of corticosteron...

journal_title：European journal of endocrinology

authors： Mulatero P,Glorioso N,Fallo F,Soro A,Morra di Cella S,Carra R,Filigheddu F,Veglio F

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Based on our clinical experience with combined gene therapy of glioblastoma, we developed a retroviral vector expressing two therapeutic genes (i.e. thymidine kinase of herpes simplex virus, HSV-TK, and interleukin-2, IL-2) and evaluated its efficiency in vitro and in vivo. METHODS:Expression of t...

journal_title：European journal of endocrinology

authors： Barzon L,Bonaguro R,Castagliuolo I,Chilosi M,Franchin E,Del Vecchio C,Giaretta I,Boscaro M,Palù G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:A significant decrease in vitamin D receptor (VDR) and calcium-sensing receptor (CaSR) protein expression has been demonstrated recently in parathyroid (PT) adenomas. In this study, we investigated the relationships between the proliferative activity of parathyroid glands (PTGs) and the expression of VDR as w...

journal_title：European journal of endocrinology

authors： Yano S,Sugimoto T,Tsukamoto T,Chihara K,Kobayashi A,Kitazawa S,Maeda S,Kitazawa R

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. DESIGN:Cross-sectional. MATERIALS AND METHODS:All patients (n=177) undergoing diagnostic evaluation and ...

journal_title：European journal of endocrinology

authors： Starup-Linde J,Waldhauer E,Rolighed L,Mosekilde L,Vestergaard P

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. DESIGN AND METHODS:The evolution over time of GD was determined in both groups according to the clinical changes a...

journal_title：European journal of endocrinology

authors： De Luca F,Corrias A,Salerno M,Wasniewska M,Gastaldi R,Cassio A,Mussa A,Aversa T,Radetti G,Arrigo T

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Serum sclerostin levels have been reported to be inversely associated with serum 25OHD levels, but the effect of vitamin D and calcium supplementation on serum sclerostin levels is unknown. This study was carried out to determine whether vitamin D and calcium supplementation altered serum sclerostin levels in...

journal_title：European journal of endocrinology

authors： Dawson-Hughes B,Harris SS,Ceglia L,Palermo NJ

更新日期：2014-03-13 00:00:00

abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...

journal_title：European journal of endocrinology

authors： Marek J,Hána V,Krsek M,Justová V,Catus F,Thomas F

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to determine vascular endothelial growth factor (VEGF), prostaglandin E(2) (PGE(2)) and active renin levels in patients with hormonally active adrenal tumours. DESIGN:The study was comprised of 16 patients with primary aldosteronism, 13 patients with active Cushing's syndrom...

journal_title：European journal of endocrinology

authors： Zacharieva S,Atanassova I,Orbetzova M,Nachev E,Kalinov K,Kirilov G,Shigarminova R,Ivanova R,Dashev G

更新日期：2004-03-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is a familial syndrome characterized by parathyroid, enteropancreatic and pituitary tumors. The gene responsible for this syndrome is localized at chromosomal 11q13 region and DNA markers from this region cosegregate with the disease. The recent identification of the MEN1 ge...

journal_title：European journal of endocrinology

authors： Morelli A,Falchetti A,Martineti V,Becherini L,Mark M,Friedman E,Brandi ML

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Phytosterolaemia (sitosterolaemia) is a rare autosomal recessive condition caused by mutations on the ABCG5 and ABCG8 gut transporter proteins. This leads to accumulation of plant-derived cholesterol-like molecules in blood and tissues. CASE:We describe a family of Bangladesh origin, where three siblings (t...

journal_title：European journal of endocrinology

authors： Mushtaq T,Wales JK,Wright NP

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Slow-release (SR) lanreotide is a long-acting somatostatin analog that has been developed in order to overcome the inconvenience of multiple daily subcutaneous injections of octreotide, required for metabolic control in acromegaly. Lanreotide SR has been found to be well tolerated and effective in reducing GH...

journal_title：European journal of endocrinology

authors： Verhelst JA,Pedroncelli AM,Abs R,Montini M,Vandeweghe MV,Albani G,Maiter D,Pagani MD,Legros JJ,Gianola D,Bex M,Poppe K,Mockel J,Pagani G

更新日期：2000-11-01 00:00:00

abstract：:To study interactions between insulin-like growth factor-II (IGF-II) and growth hormone (GH) in vivo, we crossed hemizygous transgenic mice carrying phosphoenolpyruvate carboxykinase (PEPCK)-IGF-II fusion genes with hemizygous PEPCK-bovine GH (bGH) transgenic mice. Offspring harbouring both transgenes (IB), the IGF-II...

journal_title：European journal of endocrinology

authors： Blackburn A,Dressendörfer RA,Blum WF,Erhard M,Brem G,Strasburger CJ,Wolf E

更新日期：1997-12-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：Introduction:Pathologically high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly are associated with arthropathy. Several studies highlight the potential role of the GH/IGF-1 axis in primary osteoarthritis (OA). We aimed to disentangle the role of IGF-1 levels in primary ...

journal_title：European journal of endocrinology

authors： Pelsma ICM,Claessen KMJA,Slagboom PE,van Heemst D,Pereira AM,Kroon HM,Ramos YFM,Kloppenburg M,Biermasz NR,Meulenbelt IM

更新日期：2021-01-01 00:00:00

abstract：CONTEXT:Although combination therapy of acromegaly with long-acting somatostatin analogs (LA-SSAs) and pegvisomant (PEGV) normalizes insulin-like growth factor-1 (IGF1) levels in the majority of patients, it requires long-term adherence. Switching from combination therapy to monotherapy with weekly PEGV could improve p...

journal_title：European journal of endocrinology

authors： Muhammad A,van der Lely AJ,O'Connor RD,Delhanty PJ,Dal J,Dallenga AH,Feelders RA,Janssen JA,Jorgensen JO,Neggers SJ

更新日期：2016-05-01 00:00:00