Abstract:
Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 patients (4126 patient-years) from the German Acromegaly Registry was performed. Follow-up was 1.0-45.1 years after radiotherapy. Therapeutic success was defined by low or normal IGF-1 according to center-specific reference ranges without (= remission) or on (= controlled disease) suppressive medication. Results:Time between radiotherapy and last follow-up was 13.0 ± 8.2 years for FRT (n = 233) and 8.9 ± 5.0 years for SRS (n = 119, P < 0.001). Median (IQR) basal growth hormone before radiotherapy was 6.3 (2.9-16.2) ng/mL for FRT and 3.5 (1.8-6.9) ng/mL for SRS (P < 0.001). Mean time in uncontrolled state was 3.0 years after FRT and 2.1 years after SRS (95% CI for the difference is 0.1 to 1.6 years, P = 0.021). The 10-year calculated remission rate was 48% for FRT and 52% for SRS (95% CI for the difference is -18 to 26% age points, P = 0.74) and the respective controlled disease rate was 23 and 26%. The odds ratio for adrenocorticotropic or thyreotropic insufficiency was 0.54 (95% CI: 0.30-1.00, P = 0.049) in SRS compared to FRT patients. Conclusion:Both after FRT and SRS about 75% of patients with acromegaly are in remission or controlled after 10 years. A slightly faster achievement of target values was observed after SRS. The rate of pituitary insufficiency in FRT patients is significantly higher.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.doi
10.1530/EJE-19-0784subject
Has Abstractpub_date
2020-03-01 00:00:00pages
275-284issue
3eissn
0804-4643issn
1479-683Xpii
EJE-19-0784journal_volume
182pub_type
杂志文章abstract::This is a brief review of the normal changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker for an individual's transition from a non-reproduc...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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abstract::To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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abstract::The experimental model of chronic inhibition of nitric oxide (NO) production has proven to be a useful tool to study cardiovascular and renal lesions produced by this type of hypertension, which are similar to those found in human hypertension. It also offers a unique opportunity to study the interaction of NO with th...
journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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abstract:BACKGROUND:Fetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals. OBJECTIVE:To evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA)...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0286
更新日期:2007-11-01 00:00:00
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2001-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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更新日期:1999-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0575
更新日期:2011-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1310582
更新日期:1994-12-01 00:00:00
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更新日期:2014-03-08 00:00:00
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pub_type: 杂志文章,评审
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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更新日期:1998-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1470591
更新日期:2002-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1320705
更新日期:1995-06-01 00:00:00