abstract：Background:The treatment of acromegaly resistant to first-generation somatostatin receptor ligands (SRLs) is often difficult. Pegvisomant and Pasireotide LAR are mostly used in these subset of patients, as second line therapies. Choice of the type of second line therapies is difficult, since predictors of response are ...

journal_title：European journal of endocrinology

authors： Chiloiro S,Giampietro A,Mirra F,Donfrancesco F,Tartaglione T,Mattogno PP,Angelini F,Liverana L,Gessi M,Carmelo A,Rindi G,Giustina A,Fleseriu M,Pontecorvi A,De Marinis L,Bianchi A

更新日期：2021-02-01 00:00:00

abstract：Objective:The challenge of finding patients with the rare conditon of diabetes insipidus in need of vasopressin treatment is demanding. The guidelines for performing the fluid deprivation test and interpreting the results are abundant. We evaluated the discriminative capacity of the fluid deprivation test in patients w...

journal_title：European journal of endocrinology

authors： Sjöström A,Bartuseviciene I,Höybye C

更新日期：2021-01-01 00:00:00

abstract：Introduction:Pathologically high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly are associated with arthropathy. Several studies highlight the potential role of the GH/IGF-1 axis in primary osteoarthritis (OA). We aimed to disentangle the role of IGF-1 levels in primary ...

journal_title：European journal of endocrinology

authors： Pelsma ICM,Claessen KMJA,Slagboom PE,van Heemst D,Pereira AM,Kroon HM,Ramos YFM,Kloppenburg M,Biermasz NR,Meulenbelt IM

更新日期：2021-01-01 00:00:00

abstract：:Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

journal_title：European journal of endocrinology

authors： Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

更新日期：2021-01-01 00:00:00

abstract：:none. ...

journal_title：European journal of endocrinology

authors： Chae HW,Lee YM

更新日期：2021-01-01 00:00:00

abstract：:An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescen...

journal_title：European journal of endocrinology

authors： Giannetta E,Guarnotta V,Altieri B,Sciammarella C,Guadagno E,Malandrino P,Puliani G,Feola T,Isidori AM,Colao AAL,Faggiano A

更新日期：2020-12-01 00:00:00

abstract：:Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

journal_title：European journal of endocrinology

authors： Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

更新日期：2020-12-01 00:00:00

abstract：Background:Hypophosphataemic rickets (HR) comprise a clinically and genetically heterogeneous group of conditions, defined by renal-tubular phosphate wasting and consecutive loss of bone mineralisation. X-linked hypophosphataemia (XLH) is the most common form, caused by inactivating dominant mutations in PHEX, a gene e...

journal_title：European journal of endocrinology

authors： Thiele S,Werner R,Stubbe A,Hiort O,Hoeppner W

更新日期：2020-11-01 00:00:00

abstract：:Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by bone fragility and skeletal deformities. While the majority of cases are associated with pathogenic variants in COL1A1 and COL1A2, the genes encoding type I collagen, up to 25% of cases are associated with other genes that function within...

journal_title：European journal of endocrinology

authors： Marom R,Rabenhorst BM,Morello R

更新日期：2020-10-01 00:00:00

abstract：Objective:Retrospective studies suggest that women have more active brown adipose tissue (BAT) than men, but little is known of the effect of fluctuating sex steroids across the menstrual cycle on thermogenesis in women. Design:To characterise the effects of sex and sex steroids on BAT activity we recruited healthy we...

journal_title：European journal of endocrinology

authors： Fuller-Jackson JP,Dordevic AL,Clarke IJ,Henry BA

更新日期：2020-09-01 00:00:00

abstract：:This manuscript provides guidance on the management of thyroid dysfunction during the COVID-19 pandemic. Autoimmune thyroid diseases are not linked to increased risks of COVID-19. Uncontrolled thyrotoxicosis may result in more severe complications from SARS-CoV-2 infection, including thyroid storm. The management of p...

journal_title：European journal of endocrinology

authors： Boelaert K,Visser WE,Taylor PN,Moran C,Léger J,Persani L

更新日期：2020-07-01 00:00:00

abstract：:Patients with pituitary tumours, ensuing hormonal abnormalities and mass effects are usually followed in multidisciplinary pituitary clinics and can represent a management challenge even during the times of non-pandemic. The COVID-19 pandemic has put on hold routine medical care for hundreds of millions of patients ar...

journal_title：European journal of endocrinology

authors： Fleseriu M,Dekkers OM,Karavitaki N

更新日期：2020-07-01 00:00:00

abstract：:Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), arising from gain-of-function mutations in Gαs, and cutaneous skeletal hypophosphatemia syndrome (CSHS), arising from gain-of-function mutations in the Ras/MAPK pathway, are strikingly complex, mosaic diseases with overlapping phenotypes. Both disorders are defined ...

journal_title：European journal of endocrinology

authors： de Castro LF,Ovejero D,Boyce AM

更新日期：2020-05-01 00:00:00

abstract：Objectives:Male hypogonadism is associated with higher risk of co-morbidity and premature mortality. It is, therefore, of utmost importance to identify young men who are at the highest risk of testosterone deficiency and who may benefit from preventive measures. In this context, infertile men constitute a high-risk gro...

journal_title：European journal of endocrinology

authors： Elenkov A,Al-Jebari Y,Giwercman YL,Giwercman A

更新日期：2020-04-01 00:00:00

abstract：Context:The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required f...

journal_title：European journal of endocrinology

authors： Wright C,O'Day P,Alyamani M,Sharifi N,Auchus RJ

更新日期：2020-04-01 00:00:00

abstract：Objective:Children with Prader-Willi syndrome (PWS) have mild to moderate cognitive impairment. Short-term studies showed positive effects of growth hormone (GH) on cognitive development. This study investigated the effects of 8 years of GH on cognitive development in children with PWS. We also investigated whether sta...

journal_title：European journal of endocrinology

authors： Donze SH,Damen L,Mahabier EF,Hokken-Koelega ACS

更新日期：2020-04-01 00:00:00

abstract：Objective:To evaluate the prevalence and natural course of autoimmune and non-autoimmune subclinical hypothyroidism (SH) in Down syndrome (DS) children and adolescents. Design:Prospective multicenter study. Methods:For the study, 101 DS patients with SH (TSH 5-10 mIU/L; FT4 12-22 pmol/L), aged 2-17 years at SH diagno...

journal_title：European journal of endocrinology

authors： Pepe G,Corica D,De Sanctis L,Salerno M,Faienza MF,Tessaris D,Tuli G,Scala I,Penta L,Alibrandi A,Pajno GB,Aversa T,Wasniewska M,Thyroid Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

更新日期：2020-04-01 00:00:00

abstract：Background/objective:Data on metabolic impairments in Cushing's syndrome and GH deficiency all suggest that the relationship between cortisol and GH/IGF-I axis in obesity may have a role in the related diseases. However, studies focusing only on one of these hormones are often controversial in paediatrics. We aimed to ...

journal_title：European journal of endocrinology

authors： Ricotti R,Solito A,Mariotti Zani E,Caputo M,Genoni G,Barone-Adesi F,Mancioppi V,Agosti E,Aimaretti G,Bellone S,Prodam F

更新日期：2020-03-01 00:00:00

abstract：Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

journal_title：European journal of endocrinology

authors： Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

更新日期：2020-03-01 00:00:00

abstract：Objectives:We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA). Design:Multicenter retrospective study by Japan PA study. Method:We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenal...

journal_title：European journal of endocrinology

authors： Kobayashi H,Nakamura Y,Abe M,Kurihara I,Itoh H,Ichijo T,Takeda Y,Yoneda T,Katabami T,Tsuiki M,Wada N,Ogawa Y,Sakamoto R,Kawashima J,Sone M,Inagaki N,Yoshimoto T,Yamada T,Okamoto R,Matsuda Y,Fujita M,Watanabe M,

更新日期：2020-03-01 00:00:00

abstract：Aim:To establish pancreatic alpha-cell mass in lean, non-diabetic humans over the adult lifespan, performed as a follow-up study to beta-cell mass across the adult human lifespan. Methods:We examined human pancreatic autopsy tissue from 66 lean, non-diabetic individuals aged from 30 to 102 years, grouped into deciles:...

journal_title：European journal of endocrinology

authors： Moin ASM,Cory M,Gurlo T,Saisho Y,Rizza RA,Butler PC,Butler AE

更新日期：2020-02-01 00:00:00

abstract：:Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans). GC signaling follows several consecutive step...

journal_title：European journal of endocrinology

authors： Vitellius G,Lombes M

更新日期：2020-02-01 00:00:00

abstract：Objective:Statin therapy has been linked to an increased risk of type 2 diabetes in high-risk populations; however, the pathophysiology of this association remains to be clarified. We investigated glucagon suppression and its relationship with insulin resistance in prediabetic subjects undergoing atorvastatin therapy; ...

journal_title：European journal of endocrinology

authors： Urbano F,Di Pino A,Scicali R,Filippello A,Di Mauro S,Scamporrino A,Marchisello S,Rabuazzo AM,Purrello F,Piro S

更新日期：2019-12-01 00:00:00

abstract：Objective:Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponecti...

journal_title：European journal of endocrinology

authors： Kampmann FB,Thuesen ACB,Hjort L,Bjerregaard AA,Chavarro JE,Frystyk J,Bjerre M,Tetens I,Olsen SF,Vaag AA,Damm P,Grunnet LG

更新日期：2019-12-01 00:00:00

abstract：:Pituitary adenomas are frequently occurring neoplasms that produce clinically significant disease in 1:1000 of the general population. The pathogenesis of pituitary tumors is a matter of interest as it could help to improve diagnosis and treatment. Until recently, however, disruptions in relatively few genes were know...

journal_title：European journal of endocrinology

authors： Vandeva S,Daly AF,Petrossians P,Zacharieva S,Beckers A

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of ind...

journal_title：European journal of endocrinology

authors： Meyer G,Mayer M,Mondorf A,Fluegel AK,Herrmann E,Bojunga J

更新日期：2019-11-01 00:00:00

abstract：Objective:Hypertension and symptoms of catecholamine excess are features of pheochromocytomas and paragangliomas (PPGLs). This prospective observational cohort study assessed whether differences in presenting features in patients tested for PPGLs might assist establishing likelihood of disease. Design and methods:Pati...

journal_title：European journal of endocrinology

authors： Geroula A,Deutschbein T,Langton K,Masjkur J,Pamporaki C,Peitzsch M,Fliedner S,Timmers HJLM,Bornstein SR,Beuschlein F,Stell A,Januszewicz A,Prejbisz A,Fassnacht M,Lenders JWM,Eisenhofer G

更新日期：2019-10-01 00:00:00

abstract：Objectives:Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV. Design:Cross-sectional analysis of men enrolled in the Multicente...

journal_title：European journal of endocrinology

authors： Lake JE,Debroy P,Ng D,Erlandson KM,Kingsley LA,Palella FJ,Budoff MJ,Post WS,Brown TT

更新日期：2019-10-01 00:00:00

abstract：Objective:Several clinical studies have reported that renal impairments are sometimes observed in patients with primary aldosteronism (PA). We analyzed the prevalence of renal impairments in PA patients and identified parameters that increase the risk for them. Design:This is a retrospective cross-sectional study. We ...

journal_title：European journal of endocrinology

authors： Kawashima A,Sone M,Inagaki N,Takeda Y,Itoh H,Kurihara I,Umakoshi H,Ichijo T,Katabami T,Wada N,Ogawa Y,Kawashima J,Fujita M,Miyauchi S,Okamura S,Fukuoka T,Yanase T,Izawa S,Yoshikawa Y,Hashimoto S,Yamada M,Kai T,

更新日期：2019-09-01 00:00:00

abstract：:Prediction models are of a great assistance for predicting the development of a disease, detecting or screening undiagnosed patients, predicting the effectiveness of a treatment and helping toward better decision-making. Recently, three predictive scores in the field of autoimmune thyroid disease (AITD) have been intr...

journal_title：European journal of endocrinology

authors： Effraimidis G

更新日期：2019-09-01 00:00:00

abstract：Background:Autosomal dominant neurohypophyseal diabetes insipidus (adNDI) is caused by arginine vasopressin (AVP) deficiency resulting from mutations in the AVP-NPII gene encoding the AVP preprohormone. Aim:To describe the clinical and molecular features of Italian unrelated families with central diabetes insipidus. ...

journal_title：European journal of endocrinology

authors： Patti G,Scianguetta S,Roberti D,Di Mascio A,Balsamo A,Brugnara M,Cappa M,Casale M,Cavarzere P,Cipriani S,Corbetta S,Gaudino R,Iughetti L,Martini L,Napoli F,Peri A,Salerno MC,Salerno R,Passeri E,Maghnie M,Perrotta

更新日期：2019-09-01 00:00:00

abstract：Objective:Glucocorticoid treatment of inflammatory disorders is associated with significant adverse effects related to glucocorticoid excess as well as adrenal insufficiency. This necessitates awareness of its use. We therefore investigated trends in systemic glucocorticoid use as well as morbidity and comedications am...

journal_title：European journal of endocrinology

authors： Laugesen K,Jørgensen JOL,Petersen I,Sørensen HT

更新日期：2019-09-01 00:00:00

abstract：:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...

journal_title：European journal of endocrinology

authors： Chanson P,Dormoy A,Dekkers OM

更新日期：2019-07-01 00:00:00

abstract：Objective:With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe the current experience with pediatric refugees in Germany and Austria. Design and Methods:43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were ...

journal_title：European journal of endocrinology

authors： Prinz N,Konrad K,Brack C,Hahn E,Herbst A,Icks A,Grulich-Henn J,Jorch N,Kastendieck C,Mönkemöller K,Razum O,Steigleder-Schweiger C,Witsch M,Holl RW

更新日期：2019-07-01 00:00:00

abstract：Objectives:Inoperable or metastatic paragangliomas (PGLs) and malignant pheochromocytomas (PCCs) are rare tumours with limited options for systemic treatment. Aim of this study was to assess the safety and efficacy of the radiolabelled somatostatin analogue (177LutetiumDOTA0-Tyr3)octreotate (177Lu-DOTATATE) for the tre...

journal_title：European journal of endocrinology

authors： Zandee WT,Feelders RA,Smit Duijzentkunst DA,Hofland J,Metselaar RM,Oldenburg RA,van Linge A,Kam BLR,Teunissen JJM,Korpershoek E,Hendriks JM,Abusaris H,Slagter C,Franssen GJH,Brabander T,De Herder WW

更新日期：2019-07-01 00:00:00

abstract：:Objective To investigate how weight loss by different diets impacts postprandial levels of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Methods In this single-centre, parallel group 2-year trial, 70 healthy postmenopausal obese women were randomised to the Paleolith...

journal_title：European journal of endocrinology

authors： Otten J,Ryberg M,Mellberg C,Andersson T,Chorell E,Lindahl B,Larsson C,Holst JJ,Olsson T

更新日期：2019-06-01 00:00:00

abstract：:Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria (n = 239), former participants of the randomized controlled trial (RCT) PregMet were invited, 131 p...

journal_title：European journal of endocrinology

authors： Underdal MO,Salvesen Ø,Schmedes A,Andersen MS,Vanky E

更新日期：2019-06-01 00:00:00

abstract：:The strategy for diagnosis of primary aldosteronism (PA) in the hypertensive population includes firstly a screening step, based on the measurement of plasma aldosterone-to-renin ratio (ARR), a test which must have high sensitivity, and secondly a confirmatory step based on the demonstration of excessive aldosterone p...

journal_title：European journal of endocrinology

authors： Morera J,Reznik Y

更新日期：2019-02-01 00:00:00

abstract：:Objective Chronic hypoparathyroidism and its treatment may lead to symptoms and complications affecting quality of life. We determined complications in chronic hypoparathyroid patients. Design Retrospective cross-sectional study of patients with chronic hypoparathyroidism treated with active vitamin D supplements in a...

journal_title：European journal of endocrinology

authors： David K,Moyson C,Vanderschueren D,Decallonne B

更新日期：2019-01-01 00:00:00

abstract：:Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical s...

journal_title：European journal of endocrinology

authors： Støving RK

更新日期：2019-01-01 00:00:00