当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.

The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.

Abstract：

OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits the conversion of androgens to oestrogens. We demonstrated previously that during treatment with testosterone plus letrozole the increase in testosterone concentration was more than 5-fold higher than during treatment with testosterone plus placebo. The concentrations of 17beta-oestradiol, IGF-I and IGF-binding protein-3 increased during testosterone-plus-placebo treatment, but during testosterone-plus-letrozole treatment the concentrations remained unchanged. These divergent changes in the two groups enabled us to study the effects of sex steroids and GH on insulin sensitivity and lipid concentrations. RESULTS:The insulin concentration in the testosterone-plus-placebo-treated group did not change. In contrast, in the testosterone-plus-letrozole-treated group, the concentration decreased during letrozole treatment, indicating improved insulin sensitivity. Changes in insulin and IGF-I concentrations within 12 and 18 months were correlated. In the testosterone-plus-placebo-treated group, the high-density lipoprotein cholesterol concentration did not change but in the testosterone-plus-letrozole-treated group the concentration decreased. The concentrations of low-density lipoprotein cholesterol (LDL-cholesterol) and triglycerides did not change in either of the groups. CONCLUSIONS:The findings indicate that androgens do not directly alter insulin sensitivity in boys during puberty. In contrast, the observations suggest tight regulation of glucose--insulin homeostasis by GH in boys at this stage. Furthermore, our findings indicate that sex steroids do not significantly participate in the regulation of serum concentrations of LDL-cholesterol or triglycerides in boys during early and mid-puberty.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Wickman S,Saukkonen T,Dunkel L

doi

10.1530/eje.0.1460339

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

339-46

issue

3

eissn

0804-4643

issn

1479-683X

pii

1460339

journal_volume

146

pub_type

临床试验,杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.

    abstract：OBJECTIVE:Anti-inflammatory glucocorticoid (GC) therapy often induces hyperglycemia due to insulin resistance and islet-cell dysfunction. Incretin-based therapies may preserve glucose tolerance and pancreatic islet-cell function. In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-13-0610

    authors： van Genugten RE,van Raalte DH,Muskiet MH,Heymans MW,Pouwels PJ,Ouwens DM,Mari A,Diamant M

    更新日期：2014-02-04 00:00:00

  • Regulation of spermatogenesis in McCune-Albright syndrome: lessons from a 15-year follow-up.

    abstract：CONTEXT:McCune-Albright syndrome (MAS) is a disorder caused by a post-zygotic gain-of-function mutation in the gene encoding the Gs-alpha protein. Sexual precocity, common in girls, has been reported in only 15% of boys, and little is known on the long-term evolution of MAS in males. OBJECTIVE:In a boy with MAS, we st...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0494

    authors： De Luca F,Mitchell V,Wasniewska M,Arrigo T,Messina MF,Valenzise M,de Sanctis L,Lahlou N

    更新日期：2008-06-01 00:00:00

  • Preoperative diagnosis of insulinoma: low body mass index, young age, and female gender are associated with negative imaging by endoscopic ultrasound.

    abstract：OBJECTIVE:Endoscopic ultrasound (EUS) is a highly reliable procedure to localize insulinomas preoperatively. It has been considered to be important in planning surgical strategy, especially considering a minimal invasive approach. However, even under ideal conditions experienced examiners miss about 10-20% of insulinom...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0117

    authors： Kann PH,Ivan D,Pfützner A,Forst T,Langer P,Schaefer S

    更新日期：2007-08-01 00:00:00

  • Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog.

    abstract：:Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1340073

    authors： Fanciulli G,Oliva O,Tomasi PA,Pala A,Bertoncelli A,Dettori A,Delitala G

    更新日期：1996-01-01 00:00:00

  • Endocrine control of testicular somatic and premeiotic germ cell development in the immature testis of the primate Macaca mulatta.

    abstract：:Four groups(N = 3 per group) of juvenile rhesus monkeys (Macaca mulatta, 14-20 months old) received either vehicle or highly purified human follicle-stimulating hormone (FSH; 10 IU kg-1 day-1), human chorionic gonadotropin (hCG; 250 IU every alternate day) or both hormones for a period of 4 weeks. Testicular volume an...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1330235

    authors： Schlatt S,Arslan M,Weinbauer GF,Behre HM,Nieschlag E

    更新日期：1995-08-01 00:00:00

  • Ectopic Agouti protein overexpression increases stimulated corticosterone production without effect on adenylate cyclase activity in mouse adrenal cells.

    abstract：OBJECTIVE:The antagonism of Agouti protein (AP) and Agouti-related protein on melanocortin receptors suggests an inhibitory role in the regulation of steroidogenesis. However, we have previously demonstrated that ectopic AP overexpression increased restraint-induced corticosterone release and adrenal reactivity to ACTH...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1510613

    authors： Shevchenko AY,Bazhan NM,Makarova EN,Yakovleva TV,Karkaeva NR

    更新日期：2004-11-01 00:00:00

  • Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution.

    abstract：OBJECTIVE:Both animal and human studies have associated the endocannabinoid system with obesity and markers of metabolic dysfunction. Blockade of the cannabinoid receptor 1 (CB1) caused weight loss and reduction in waist size in both obese and type II diabetics. Recent studies on common variants of the CB1 receptor gen...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-10-0192

    authors： Frost M,Nielsen TL,Wraae K,Hagen C,Piters E,Beckers S,De Freitas F,Brixen K,Van Hul W,Andersen M

    更新日期：2010-09-01 00:00:00

  • Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.

    abstract：:Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or le...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1320594

    authors： Dumoulin SC,Perret BP,Bennet AP,Caron PJ

    更新日期：1995-05-01 00:00:00

  • Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise.

    abstract：:Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the pot...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0064

    authors： Hew-Butler T,Noakes TD,Soldin SJ,Verbalis JG

    更新日期：2008-12-01 00:00:00

  • The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome.

    abstract：OBJECTIVE:Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs m...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01913

    authors： Zervolea I,Pratsinis H,Tsagarakis S,Karavitaki N,Stathakos D,Thalassinos N,Kletsas D

    更新日期：2005-06-01 00:00:00

  • Reduction of insulin secretion in the insulinoma cell line INS-1 by overexpression of a Ca(v)2.3 (alpha1E) calcium channel antisense cassette.

    abstract：OBJECTIVE:Multiple types of voltage-activated Ca(2+) channels (T, L, N, P, Q and R type) coordinate a variety of Ca(2+)-dependent processes in neurons and neuroendocrine cells. In insulinoma cell lines as well as in endocrine tissues, the non-L-type alpha1E (Ca(v)2.3) subunit is expressed as the tissue-specific splice ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1460881

    authors： Pereverzev A,Vajna R,Pfitzer G,Hescheler J,Klöckner U,Schneider T

    更新日期：2002-06-01 00:00:00

  • Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment.

    abstract：UNLABELLED:In healthy boys, the pituitary-gonadal axis exhibits diurnal variation in early puberty. Serum testosterone levels are higher during the night and low or immeasurable during the day. These fluctuating levels of circulating androgens in early pubertal boys are difficult to monitor. Prostate specific antigen (...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360401

    authors： Juul A,Müller J,Skakkebaek NE

    更新日期：1997-04-01 00:00:00

  • Altered urinary excretion of aquaporin 2 in IgA nephropathy.

    abstract：OBJECTIVE:The intrarenal renin-angiotensin system (RAS) activation plays a pivotal role in immunoglobulin A nephropathy (IgAN) pathogenesis, which is still largely undefined. Recently, vasopressin (AVP) has been advocated to contribute to the genesis and progression of chronic kidney diseases (CKD) directly, and indire...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0512

    authors： Rocchetti MT,Tamma G,Lasorsa D,Suriano IV,D'Apollo A,Papale M,Mastrofrancesco L,Grandaliano G,Svelto M,Valenti G,Gesualdo L,Di Paolo S

    更新日期：2011-10-01 00:00:00

  • Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis.

    abstract：OBJECTIVE:In malnutrition both the GH-IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. DESIGN AND METHODS:Peripubertal (30 days of age) f...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470417

    authors： Goya L,García-Segura LM,Ramos S,Pascual-Leone AM,Argente J,Martín MA,Chowen JA

    更新日期：2002-09-01 00:00:00

  • Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians.

    abstract：OBJECTIVE:Previously, it has been demonstrated that receptor protein tyrosine phosphatase sigma (RPTPsigma) is involved in glucose homeostasis and insulin signaling in several animal models. The aim of this study was to evaluate whether polymorphisms in this gene influence the development of type 2 diabetes (T2D) in hu...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0114

    authors： Långberg EC,Gu HF,Nordman S,Efendic S,Ostenson CG

    更新日期：2007-10-01 00:00:00

  • Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis.

    abstract：OBJECTIVE:The relationship between sex hormones and hepatocellular adenoma development is well established. On the contrary, their contribution to liver adenomatosis (LA) development is still a debatable issue. Recently, inactivating mutations of hepatocyte nuclear factor-1alpha (HNF-1alpha) transcription factor gene o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0020

    authors： Svrcek M,Jeannot E,Arrivé L,Poupon R,Fromont G,Fléjou JF,Zucman-Rossi J,Bouchard P,Wendum D

    更新日期：2007-06-01 00:00:00

  • Quantitave and qualitative changes in vascular endothelial growth factor gene expression in glomeruli of patients with type 2 diabetes.

    abstract：OBJECTIVE:Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF 121, VEGF 165 and VEGF 189) and acts via two specific receptors: VEGF-R1 or Flt-1 and VEGF-R2 or KDR. VEGF plays an important role in the pathogenesis of diabetic retinopathy. Th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500799

    authors： Bortoloso E,Del Prete D,Dalla Vestra M,Gambaro G,Saller A,Antonucci F,Baggio B,Anglani F,Fioretto P

    更新日期：2004-06-01 00:00:00

  • Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.

    abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-17-0111

    authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

    更新日期：2017-07-01 00:00:00

  • 11 beta-Hydroxysteroid dehydrogenase deficit: a rare cause of arterial Hypertension. Diagnosis and therapeutic approach in two young brothers.

    abstract：:We report the clinical history and results of endocrine investigations in two brothers born to consanguineous parents, who presented with hypokalemia and arterial hypertension when they were aged 2 and 6 years. The hormonal serum assay results, including extremely low values for aldosterone and plasma renin activity, ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1350238

    authors： Gourmelen M,Saint-Jacques I,Morineau G,Soliman H,Julien R,Fiet J

    更新日期：1996-08-01 00:00:00

  • Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels.

    abstract：OBJECTIVE:Previous evidence has suggested that a low sex hormone-binding globulin (SHBG) concentration is associated with insulin-resistance and a low adiponectin concentration. We investigated the association between SHBG and the risk of hyperglycemia in each sex and we determined potential interactions between SHBG a...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0202

    authors： Bonnet F,Balkau B,Malécot JM,Picard P,Lange C,Fumeron F,Aubert R,Raverot V,Déchaud H,Tichet J,Lecomte P,Pugeat M,DESIR Study Group.

    更新日期：2009-07-01 00:00:00

  • The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.

    abstract：BACKGROUND:Ghrelin stimulates GH secretion and regulates energy and glucose metabolism. The two circulating isoforms, acyl (AG) and des-acyl (DAG) ghrelin, have distinct metabolic effects and are under active investigation for their therapeutic potentials. However, there is only limited data on the pharmacokinetics of ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-13-0072

    authors： Tong J,Dave N,Mugundu GM,Davis HW,Gaylinn BD,Thorner MO,Tschöp MH,D'Alessio D,Desai PB

    更新日期：2013-05-02 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.

    abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-17-0920

    authors： Canalis E

    更新日期：2018-02-01 00:00:00

  • Skeletal muscle mitochondrial function in polycystic ovarian syndrome.

    abstract：OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0419

    authors： Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

    更新日期：2011-10-01 00:00:00

  • A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes (IMDIAB IX).

    abstract：OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1500719

    authors： Crinò A,Schiaffini R,Manfrini S,Mesturino C,Visalli N,Beretta Anguissola G,Suraci C,Pitocco D,Spera S,Corbi S,Matteoli MC,Patera IP,Manca Bitti ML,Bizzarri C,Pozzilli P,IMDIAB group.

    更新日期：2004-05-01 00:00:00

  • Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women.

    abstract：:Previous reports of a correlation between serum dehydroepiandrosterone sulfate (DHEAS) and testosterone in both men and women have led to the suggestion that adrenal and gonadal secretion are related. In the present study, the correlation of DHEAS with testosterone and free testosterone (FT) in both normal men and wom...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1340201

    authors： Phillips GB

    更新日期：1996-02-01 00:00:00

  • Exaggerated blood pressure response to angiotensin II in patients with Cushing's syndrome due to adrenocortical adenoma.

    abstract：:We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1310582

    authors： Yasuda G,Shionoiri H,Umemura S,Takasaki I,Ishii M

    更新日期：1994-12-01 00:00:00

  • Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry.

    abstract：OBJECTIVES:The French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly. METHODS:Th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-1050

    authors： Fieffe S,Morange I,Petrossians P,Chanson P,Rohmer V,Cortet C,Borson-Chazot F,Brue T,Delemer B,French Acromegaly Registry.

    更新日期：2011-06-01 00:00:00

  • IGF-I increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism.

    abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0532

    authors： Dimitriadis G,Maratou E,Boutati E,Kollias A,Tsegka K,Alevizaki M,Peppa M,Raptis SA,Hadjidakis DJ

    更新日期：2008-03-01 00:00:00

  • Transition in endocrinology: induction of puberty.

    abstract：:Puberty is the period during which we attain adult secondary sexual characteristics and reproductive capability. Its onset depends upon reactivation of pulsative GNRH, secretion from its relative quiescence during childhood, on the background of intact potential for pituitary-gonadal function. This review is intended:...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0894

    authors： Dunkel L,Quinton R

    更新日期：2014-06-01 00:00:00

  • Recombinant growth hormone and insulin-like growth factor I do not alter gonadotrophin stimulation of the baboon testis in vivo.

    abstract：:In vitro studies indicate a physiological role for insulin-like growth factor I (IGF-I) in paracrine regulation of testicular function and recent clinical studies suggest a potential role for growth hormone (GH) and/or IGF-I in the treatment of hypogonadotrophic states in males. This study aimed to examine the effects...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1310405

    authors： Crawford BA,Handelsman DJ

    更新日期：1994-10-01 00:00:00