Long-term effects of cranial irradiation for childhood malignancy on sleep in adulthood.

abstract：OBJECTIVE:17-Hydroxyprogesterone (17-OHP) screening for classical congenital adrenal hyperplasia (CAH) is part of many newborn screening programs worldwide. Cut-off values are relatively high, and screening sensitivity does not reach 100%. Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to rela...

journal_title：European journal of endocrinology

authors： Schreiner F,Tozakidou M,Maslak R,Holtkamp U,Peter M,Gohlke B,Woelfle J

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Height variability is largely under genetic control, although identifying the genetic variants involved has been until recently challenging. Smallness for gestational age (SGA) is a risk factor for adult short stature. Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs1...

journal_title：European journal of endocrinology

authors： Bouatia-Naji N,Marchand M,Cavalcanti-Proença C,Daghmoun S,Durand E,Tichet J,Marre M,Balkau B,Froguel P,Lévy-Marchal C

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Iodine deficiency has re-emerged in New Zealand, while selenium status has improved. The aim of this study was to investigate the effects of excess iodine intake as iodate on thyroid and selenium status. METHODS:In a randomized controlled trial on older people (mean±s.d. 73±4.8 years; n=143), two groups rece...

journal_title：European journal of endocrinology

authors： Thomson CD,Campbell JM,Miller J,Skeaff SA

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options. PURPOSE:We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD i...

journal_title：European journal of endocrinology

authors： Struja T,Fehlberg H,Kutz A,Guebelin L,Degen C,Mueller B,Schuetz P

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Circulating IGF1 declines with age while ill-health increases. Controversy remains whether differences in the levels of IGF1 and its binding proteins 1 and 3 (IGFBP1 and IGFBP3) determine health outcomes during ageing. We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular morta...

journal_title：European journal of endocrinology

authors： Yeap BB,Chubb SA,McCaul KA,Ho KK,Hankey GJ,Norman PE,Flicker L

更新日期：2011-05-01 00:00:00

abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...

journal_title：European journal of endocrinology

authors： Marek J,Hána V,Krsek M,Justová V,Catus F,Thomas F

更新日期：1994-07-01 00:00:00

abstract：:With the use of two central health registries in Sweden, the Hospital Discharge Registry and the Medical Birth Registry, we identified 100 infants born of women who had been hospitalized for diabetes insipidus. By checking the medical records of these women, 29 infants were identified whose mothers had diabetes insipi...

journal_title：European journal of endocrinology

authors： Källén BA,Carlsson SS,Bengtsson BK

更新日期：1995-02-01 00:00:00

abstract：:Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the pot...

journal_title：European journal of endocrinology

authors： Hew-Butler T,Noakes TD,Soldin SJ,Verbalis JG

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Epidemiological studies suggest that hypopituitary patients have an increased risk for cardiovascular mortality. The dyslipidaemia associated with this condition is often characterised by an increase in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol (LDL-C) and may contribute to these f...

journal_title：European journal of endocrinology

authors： Christ ER,Cummings MH,Stolinski M,Jackson N,Lumb PJ,Wierzbicki AS,Sönksen PH,Russell-Jones DL,Umpleby AM

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...

journal_title：European journal of endocrinology

authors： Wu D,Li L,Yang M,Liu H,Yang G

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia. DESIGN:Clinical evaluation and genetic analysis of CASR gene. Functional characterization of mutated CASRs. METHODS:Direct sequencing of CASR gene in...

journal_title：European journal of endocrinology

authors： Cetani F,Lemmi M,Cervia D,Borsari S,Cianferotti L,Pardi E,Ambrogini E,Banti C,Brown EM,Bagnoli P,Pinchera A,Marcocci C

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II). DESIGN:The pituitary gland morphology in magnetic resonance imaging (MRI) of children with IGHD type II was analyzed and compared with the findings in a group ...

journal_title：European journal of endocrinology

authors： Binder G,Nagel BH,Ranke MB,Mullis PE

更新日期：2002-12-01 00:00:00

abstract：:To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

journal_title：European journal of endocrinology

authors： Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:Slow-release (SR) lanreotide is a long-acting somatostatin analog that has been developed in order to overcome the inconvenience of multiple daily subcutaneous injections of octreotide, required for metabolic control in acromegaly. Lanreotide SR has been found to be well tolerated and effective in reducing GH...

journal_title：European journal of endocrinology

authors： Verhelst JA,Pedroncelli AM,Abs R,Montini M,Vandeweghe MV,Albani G,Maiter D,Pagani MD,Legros JJ,Gianola D,Bex M,Poppe K,Mockel J,Pagani G

更新日期：2000-11-01 00:00:00

abstract：CONTEXT:It is unknown whether the metabolic effects of the removal of an adrenal incidentaloma (AI) can be predicted by the assessment of cortisol hypersecretion before surgery. OBJECTIVE:To evaluate the accuracy of several criteria of hypothalamic-pituitary-adrenal axis activity in predicting the metabolic outcome af...

journal_title：European journal of endocrinology

authors： Eller-Vainicher C,Morelli V,Salcuni AS,Battista C,Torlontano M,Coletti F,Iorio L,Cairoli E,Beck-Peccoz P,Arosio M,Ambrosi B,Scillitani A,Chiodini I

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Short stature caused by point mutations or deletions of the short stature homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with a SHOX enhancer deletion (SED) have a similar phenotype, but their response to GH is unknown. It is uncertain if duplication...

journal_title：European journal of endocrinology

authors： Donze SH,Meijer CR,Kant SG,Zandwijken GR,van der Hout AH,van Spaendonk RM,van den Ouweland AM,Wit JM,Losekoot M,Oostdijk W

更新日期：2015-11-01 00:00:00

abstract：:Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

journal_title：European journal of endocrinology

authors： Fanciulli G,Oliva O,Tomasi PA,Pala A,Bertoncelli A,Dettori A,Delitala G

更新日期：1996-01-01 00:00:00

abstract：:A pheochromocytoma in a pregnant patient is one of the most threatening medical conditions for mother, fetus, and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumor is notorious for its devastating consequences. As in non-pregnant patients, the signs and symptoms are qui...

journal_title：European journal of endocrinology

authors： Lenders JW

更新日期：2012-02-01 00:00:00

abstract：:Prediction models are of a great assistance for predicting the development of a disease, detecting or screening undiagnosed patients, predicting the effectiveness of a treatment and helping toward better decision-making. Recently, three predictive scores in the field of autoimmune thyroid disease (AITD) have been intr...

journal_title：European journal of endocrinology

authors： Effraimidis G

更新日期：2019-09-01 00:00:00

abstract：CONTEXT:The diagnosis of central hypothyroidism (CH) is often difficult to establish as serum TSH levels may be low, normal, or slightly increased. OBJECTIVE:To explore the use of recombinant human TSH (rhTSH) in the diagnosis of CH. DESIGN:Randomized single-blind clinical trial. SETTING:Outpatient clinic of a terti...

journal_title：European journal of endocrinology

authors： Filipsson H,Nyström E,Johannsson G

更新日期：2008-08-01 00:00:00

abstract：Objective:The challenge of finding patients with the rare conditon of diabetes insipidus in need of vasopressin treatment is demanding. The guidelines for performing the fluid deprivation test and interpreting the results are abundant. We evaluated the discriminative capacity of the fluid deprivation test in patients w...

journal_title：European journal of endocrinology

authors： Sjöström A,Bartuseviciene I,Höybye C

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

journal_title：European journal of endocrinology

authors： Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

更新日期：2011-10-01 00:00:00

abstract：:Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet's effects in patien...

journal_title：European journal of endocrinology

authors： Kawata T,Imanishi Y,Kobayashi K,Kenko T,Wada M,Ishimura E,Miki T,Nagano N,Inaba M,Arnold A,Nishizawa Y

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:In the field of fine-needle aspiration cytology, the category of suspicious for malignancy (SM) thyroid lesions, that bears 55-85% risk of malignant histology, is a challenging topic in which morphology alone is not always able to make a correct diagnosis. Recently, immunocytochemistry (ICC) has been referred...

journal_title：European journal of endocrinology

authors： Rossi ED,Martini M,Capodimonti S,Straccia P,Cenci T,Lombardi CP,Pontecorvi A,Larocca LM,Fadda G

更新日期：2013-05-02 00:00:00

abstract：CONTEXT:Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). OBJECTIVE:To elucidate both cortical and trabecular bone microarchi...

journal_title：European journal of endocrinology

authors： Silva PPB,Amlashi FG,Yu EW,Pulaski-Liebert KJ,Gerweck AV,Fazeli PK,Lawson E,Nachtigall LB,Biller BMK,Miller KK,Klibanski A,Bouxsein M,Tritos NA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...

journal_title：European journal of endocrinology

authors： Narumi S,Araki S,Hori N,Muroya K,Yamamoto Y,Asakura Y,Adachi M,Hasegawa T

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and...

journal_title：European journal of endocrinology

authors： Rao D,Peitzsch M,Prejbisz A,Hanus K,Fassnacht M,Beuschlein F,Brugger C,Fliedner S,Langton K,Pamporaki C,Gudziol V,Stell A,Januszewicz A,Timmers HJLM,Lenders JWM,Eisenhofer G

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim wa...

journal_title：European journal of endocrinology

authors： Gallo M,Aragno M,Gatto V,Tamagno E,Brignardello E,Manti R,Danni O,Boccuzzi G

更新日期：1999-07-01 00:00:00

abstract：Background:The treatment of acromegaly resistant to first-generation somatostatin receptor ligands (SRLs) is often difficult. Pegvisomant and Pasireotide LAR are mostly used in these subset of patients, as second line therapies. Choice of the type of second line therapies is difficult, since predictors of response are ...

journal_title：European journal of endocrinology

authors： Chiloiro S,Giampietro A,Mirra F,Donfrancesco F,Tartaglione T,Mattogno PP,Angelini F,Liverana L,Gessi M,Carmelo A,Rindi G,Giustina A,Fleseriu M,Pontecorvi A,De Marinis L,Bianchi A

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00