Abstract:
OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of SPARC in glucose metabolism. The aim of this study was to determine whether plasma SPARC concentrations were altered in subjects with different glucose metabolic conditions and to investigate the affecting factors. DESIGN AND METHODS:In this study, 54 newly diagnosed T2DM subjects, 53 subjects with impaired glucose regulation (IGR), and 53 normal subjects (body mass index (BMI): 24.98 ± 3.75 vs 24.70 ± 2.78 and 24.53 ± 3.66 kg/m(2), P>0.05) were enrolled. Plasma SPARC levels were measured with an ELISA under overnight fasting conditions. The relationships between plasma SPARC and several metabolic factors, such as BMI, blood lipids, blood glucose, plasma insulin levels, and other factors were also assessed. Results SPARC levels were higher in subjects with T2DM compared with IGR and control subjects (16.74 ± 6.99 vs 14.04 ± 8.03 μg/l, P<0.05 and 16.74 ± 6.99 vs 11.72 ± 4.47 μg/l, P<0.01). However, there was no difference in plasma SPARC levels between IGR subjects and the controls. Plasma SPARC levels correlated positively with BMI, the percentage of fat, triglyceride, fasting plasma insulin, 2 h plasma insulin after a glucose load, and the homeostasis model assessment of insulin resistance in simple regression analysis. CONCLUSION:The present work indicates a potential link between SPARC and the pathogenesis of T2DM.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Wu D,Li L,Yang M,Liu H,Yang Gdoi
10.1530/EJE-11-0131subject
Has Abstractpub_date
2011-10-01 00:00:00pages
597-601issue
4eissn
0804-4643issn
1479-683Xpii
EJE-11-0131journal_volume
165pub_type
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00