Abstract：
:With the use of two central health registries in Sweden, the Hospital Discharge Registry and the Medical Birth Registry, we identified 100 infants born of women who had been hospitalized for diabetes insipidus. By checking the medical records of these women, 29 infants were identified whose mothers had diabetes insipidus prior to the pregnancy and had been treated through the pregnancy with desmopressin. These infants had a normal birth weight and gestational length; there was only one congenital malformation identified (a ventricular septum defect with a patent ductus arteriosus and simian lines). This child died at the age of 14 years in a hypophyseal disease. This is the largest material published on desmopressin during pregnancy. The results suggest that maternal diabetes insipidus and treatment with desmopressin during the whole pregnancy does not constitute a major risk for the infant.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Källén BA,Carlsson SS,Bengtsson BKdoi
10.1530/eje.0.1320144subject
Has Abstractpub_date
1995-02-01 00:00:00pages
144-6issue
2eissn
0804-4643issn
1479-683Xjournal_volume
132pub_type
杂志文章abstract：:Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical efficacy and the safety profile of ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-16-0552
更新日期：2017-02-01 00:00:00
abstract：:The secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is regulated by gonadotropin-releasing hormone (GnRH). As men age, mean serum concentrations of immunoreactive gonadotropic hormones tend to increase, while serum testosterone concentrations tend to decline. To evaluate age-related change...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1350399
更新日期：1996-10-01 00:00:00
abstract：:The strategy for diagnosis of primary aldosteronism (PA) in the hypertensive population includes firstly a screening step, based on the measurement of plasma aldosterone-to-renin ratio (ARR), a test which must have high sensitivity, and secondly a confirmatory step based on the demonstration of excessive aldosterone p...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-18-0704
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:In type I diabetes mellitus, early markers of beta cell damage are needed in order to detect the infraclinical development of the disease. The reg protein may be a good candidate, as the reg gene has been proposed to play a role in the pancreatic beta cell destruction/regeneration process during diabetogenesi...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1410368
更新日期：1999-10-01 00:00:00
abstract：:Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-15-0605
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia and inappropriately low PTH concentrations. ADH type 1 is caused by activating mutations in the calcium-sensing receptor (CASR), a G-protein-coupled receptor signaling through α11 (Gα11) and αq (Gαq) subunits. Heterozygous activating mutat...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0109
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To compare baseline characteristics in adult patients with growth hormone (GH) deficiency (GHD) who had previously been treated for Cushing's disease or acromegaly with data from patients with GHD of other aetiologies. To study the effects of GH therapy in those patients who had completed at least 6 months of...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460067
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. DESIGN:Population based, cross-sectional study. METHODS:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical his...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1510167
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVE:Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin®. Local tolerability and treatment satisfaction were also assessed. DESIGN:26-week randomized, con...
journal_title：European journal of endocrinology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1530/EJE-17-1073
更新日期：2018-05-01 00:00:00
abstract：:Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantis...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-07-0348
更新日期：2007-10-01 00:00:00
abstract：Objective:Children with Prader-Willi syndrome (PWS) have mild to moderate cognitive impairment. Short-term studies showed positive effects of growth hormone (GH) on cognitive development. This study investigated the effects of 8 years of GH on cognitive development in children with PWS. We also investigated whether sta...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-19-0479
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1460339
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Hypochondroplasia (HCH) is a skeletal dysplasia inherited in an autosomal dominant manner due, in most cases, to mutations in the fibroblast growth factor receptor 3 (FGFR3). Acanthosis nigricans (AN) is a velvety and papillomatous pigmented hyperkeratosis of the skin, which has been recognized in some genet...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0393
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Prolactin is capable of both trophic and lytic actions in rat corpora lutea. In corpora lutea responding to a trophic prolactin signal, the long form of the prolactin receptor is the dominant form and is upregulated by prolactin. We investigated whether mRNA for the short form of the prolactin receptor was do...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1430285
更新日期：2000-08-01 00:00:00
abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-11-0454
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Fetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals. OBJECTIVE:To evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA)...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0286
更新日期：2007-11-01 00:00:00
abstract：:The aim of this study was to assess the usefulness of ketoconazole as a therapeutic alternative to polycystic ovary syndrome. The study group comprised 37 women with signs of hyperandrogenism (hirsutism, acne) and oligomenorrhea. A low dose (400 mg/day) of ketoconazole was tested in a 9-month prospective clinical stud...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1300333
更新日期：1994-04-01 00:00:00
abstract：:Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.1430447
更新日期：2000-10-01 00:00:00
abstract：INTRODUCTION:Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent B...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0239
更新日期：2008-07-01 00:00:00
abstract：:In non-functioning pituitary macroadenoma (NFMA), hyperprolactinaemia (hyperPRL) is considered to be a sign of hypothalamic-pituitary dysregulation, but it is unknown whether hyperPRL is associated with an increased frequency of pituitary hormone deficiencies. Forty consecutive patients with histology-proven NFMA were...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1350299
更新日期：1996-09-01 00:00:00
abstract：:Children with cystic fibrosis (CF) have problems with poor linear growth and inadequate weight gain. Nutritional augmentation has been the mainstay of therapy for improving both weight and height in CF; however, inadequate growth continues to be a problem. Furthermore, protein catabolism has been documented even in no...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.151s081
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVE:Although the beneficial effects of estrogen on bone are well known, the roles of estrogen receptors (ERs) in mediating these effects are not fully understood. METHODS:To study the effects of long-term ER alpha deficiency, bone phenotype was studied in aged ER alpha knockout (ERKO) mice. In addition, ERKO ost...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.01832
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND/AIM:Our previous studies showed that administration of dexamethasone plus food increased serum leptin levels 100% more than dexamethasone alone. We hypothesized that this increase in leptin from the meal could result directly from the provision of fuel metabolites rather than from the meal-induced rise in in...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1480669
更新日期：2003-06-01 00:00:00
abstract：:Glucocorticoids (GCs) inhibit bone formation in vivo and inhibit osteoblast proliferation and collagen synthesis in vitro. These effects may be mediated by alterations in the insulin-like growth factor (IGF) system. In the present study of normal human osteoblast-like (HOB) cells, we tested the hypothesis that dexamet...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1340591
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:In order to characterize urinary gonadotropin peptide (UGP) as an acute phase reactant, we focused on the UGP levels after surgical operation. DESIGN:Fifty cases of gastrointestinal cancer, 4 cases of cancers of other organs and 13 cases of benign digestive diseases were enrolled into this study. METHODS:UG...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1400555
更新日期：1999-06-01 00:00:00
abstract：:Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1410521
更新日期：1999-11-01 00:00:00
abstract：:Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pat...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.1.02088
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:In malnutrition both the GH-IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. DESIGN AND METHODS:Peripubertal (30 days of age) f...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1470417
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:We intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents. METHODS:The study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had thei...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0212
更新日期：2008-07-01 00:00:00
abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370200
更新日期：1997-08-01 00:00:00
